The training program of the Division of Renal Diseases and Hypertension at the University of Colorado at Denver and Health Sciences Center provides an integrated 3-4 year experience in clinical nephrology (one year) and academic research (2-3 years). The program is designed to prepare postdoctoral fellows for careers in academic medicine. The clinical training, by utilizing 3 different hosptials with varied populations (University Hospital, Veterans Affairs Medical Center, and Denver Health Medical Center) exposes the trainees to a great range of patients with parenchymal renal diseases, fluid and electrolyte disorders, acid-base disorders, hypertension, acute and chronic renal failure, acute renal replacement therapies, and chronic dialysis (peritoneal and hemodialysis, both at home and in-center), and all medical aspects of transplantation. Thereafter the fellows choose to pursue their research training in the laboratory of any faculty member in the Division, or other Divisions with which we closely interact, such as rheumatology and immunology. The laboratories have modern, state of the art equipment and staff that provide the best possible research environment. The fellows can choose from a large number of laboratories or clinical investigation projects. Very broadly stated these include: a) laboratories studying the pathogenesis of acute renal injury;b) laboratories exploring the role of aquaporins in disorders of water balance;c) laboratories focused on singaling pathways in vascular smooth muscle cells, tumor cells, inner medullary collecting duct cells;d) laboratories studying mechanisms of osmotolerance;e) laboratories that study the pathogenesis of renal cyst formation;f) laboratories that study the role of lipids and nuclear receptors in diabetes and aging;g) clinical studies in patients with diabetes, diabetic nephropathy, acute renal injury, polycysitc kidney disease, graft rejection, chronic kideny disease and end stage renal disease. Fellows are encouraged to enter a program leading to a Masters or Ph.D. in human biology that further broadens the research options available to them. The fellowship program chooses 4 trainees each year, all of who commit to at least a 3 years of training and express interest in an academic career. Interviewees are chosen from applicants who have completed at least three years of postdoctoral training in internal medicine. This ensures that the individual is ready for his or her clinical training, which is then followed by their research training.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007135-38
Application #
8134309
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
1983-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
38
Fiscal Year
2011
Total Cost
$164,575
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Scherer, Jennifer S; Combs, Sara A; Brennan, Frank (2017) Sleep Disorders, Restless Legs Syndrome, and Uremic Pruritus: Diagnosis and Treatment of Common Symptoms in Dialysis Patients. Am J Kidney Dis 69:117-128
Jain, Swati; Keys, Daniel; Martin, Sandra et al. (2016) Protection From Apoptotic Cell Death During Cold Storage Followed by Rewarming in 13-Lined Ground Squirrel Tubular Cells: The Role of Prosurvival Factors X-Linked Inhibitor of Apoptosis and PhosphoAkt. Transplantation 100:538-45
Montford, John R; Lehman, Allison M B; Scobey, Micah S et al. (2016) Cytosolic phospholipase A2? increases proliferation and de-differentiation of human renal tubular epithelial cells. Prostaglandins Other Lipid Mediat 126:1-8
Renner, Brandon; Tong, Hua Hua; Laskowski, Jennifer et al. (2016) Annexin A2 Enhances Complement Activation by Inhibiting Factor H. J Immunol 196:1355-65
Combs, Sara A; Davison, Sara N (2015) Palliative and end-of-life care issues in chronic kidney disease. Curr Opin Support Palliat Care 9:14-9
Stites, Erik; Le Quintrec, Moglie; Thurman, Joshua M (2015) The Complement System and Antibody-Mediated Transplant Rejection. J Immunol 195:5525-31
Combs, Sara A; Teixeira, J Pedro; Germain, Michael J (2015) Pruritus in Kidney Disease. Semin Nephrol 35:383-91
Combs, Sara A; Culp, Stacey; Matlock, Daniel D et al. (2015) Update on end-of-life care training during nephrology fellowship: a cross-sectional national survey of fellows. Am J Kidney Dis 65:233-9
Teixeira, J Pedro; Combs, Sara A; Teitelbaum, Isaac (2015) Peritoneal dialysis: update on patient survival. Clin Nephrol 83:1-10
Jain, Swati; Keys, Daniel; Nydam, Trevor et al. (2015) Inhibition of autophagy increases apoptosis during re-warming after cold storage in renal tubular epithelial cells. Transpl Int 28:214-23

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