The training program of the Division of Renal Diseases and Hypertension at the University of Colorado Denver provides an integrated 3-4 year experience in clinical nephrology (one year) and academic research (2-3 years). The program is designed to prepare postdoctoral fellows for careers in academic renal medicine. By utilizing 3 different hospitals with varied populations (University of Colorado Hospital, Veterans Affairs Medical Center, and Denver Health Medical Center), the fellows' clinical training exposes the trainees to a great range of patients with parenchymal renal diseases, fluid and electrolyte disorders, acid-base disorders, hypertension, acute and chronic kidney disease, acute renal replacement therapies, and chronic dialysis (peritoneal and hemodialysis, both at home and in-center), and all medical aspects of transplantation. Thereafter the fellows choose to pursue their research training in the laboratory or clinical research group of any faculty member in the Division, or other Divisions with which we closely interact, such as rheumatology and immunology. The laboratories have modern, state of the art equipment and staff that provide the best possible research environment. The fellows can choose from a large number of laboratories or clinical investigation related projects. Major research areas include acute kidney injury and chronic kidney disease, glomerulonephritis, diabetic nephropathy, polycystic kidney disease, hypertension and vascular disease, fluid and electrolytes with emphasis on calcium-phosphate metabolism and vasopressin, metabolism and aging, and transplantation. Research encompasses wide possibilities from basic research involving molecular and cell biology, to translational research involving animal models, to clinical studies from epidemiology to interventional studies on endothelial function to genetic studies and large clinical trials. Fellow are encouraged to enter a program leading to a Masters or Ph.D. in human biology that further broadens the research options available to them. The fellowship training program chooses 4 trainees each year, all of who commit to at least 3 years of training and express interest in an academic career. Interviewees are chosen from applicants who have completed at least three years of postdoctoral training in internal medicine. This ensures that the individual is ready for his or her clinical training, which is then followed by their research training.

Public Health Relevance

The Division of Renal Diseases and Hypertension training program provides training for renal fellows and postdoctoral scientists interested in pursuing academic careers in basic, translational or clinical research in the areas of kidney disease, hypertension and metabolic disorders, and dialysis and transplantation. Training physicians and scientists in the area of hypertension and kidney disease may lead to new discoveries and advances in treatment which can ultimately reduce the burdens of kidney disease and hypertension that currently affect more than 20 million and 70 million adults in the United States, respectively.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007135-42
Application #
9081576
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
1983-07-01
Project End
2019-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
42
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Craighead, Daniel H; Wang, Huilei; Santhanam, Lakshmi et al. (2018) Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women. Am J Physiol Heart Circ Physiol 314:H424-H433
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Craighead, Daniel H; Alexander, Lacy M (2017) Menthol-Induced Cutaneous Vasodilation Is Preserved in Essential Hypertensive Men and Women. Am J Hypertens 30:1156-1162
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Jain, Swati; Keys, Daniel; Martin, Sandra et al. (2016) Protection From Apoptotic Cell Death During Cold Storage Followed by Rewarming in 13-Lined Ground Squirrel Tubular Cells: The Role of Prosurvival Factors X-Linked Inhibitor of Apoptosis and PhosphoAkt. Transplantation 100:538-45
Montford, John R; Lehman, Allison M B; Scobey, Micah S et al. (2016) Cytosolic phospholipase A2? increases proliferation and de-differentiation of human renal tubular epithelial cells. Prostaglandins Other Lipid Mediat 126:1-8

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