This is a request for the eighth consecutive renewal of a T-32 award for training postdoctoral candidates in research to prepare them for leadership roles in academic gastroenterology. TRAINING RECORD: Over the last ten years, a total of 18 trainees have graduated;13/18 trainees pursued a research oriented career after training, and 4 received NIH funding. One of the trainees was from an under-represented minority. ADMINISTRATION: Dr. Arun Sanyal, a senior funded investigator and the director of the division of gastroenterology at VCU Medical Center, is the director of this T-32 program. He is supported by the executive committee that advises him and helps execute the training program, and a steering committee that evaluates the overall direction of the program. PROGRAM ORGANIZATION: There are five major participating units: (1) Enteric neuro-muscular and epithelial biology, (2) Hepatobiliary lipids, (3) GI cancer, (4) Clinical- Translational and (5) Alcohol related disorders. There are a total of 25 participating faculty who are all independently funded with annual NIH research base (direct costs) of $ 23.5 million. Over the last ten years, the faculty have published 907 medline-indexed papers;the average impact factor of papers published by members of the division of gastroenterology is 17.31. There are extensive collaborative networks between the faculty members who also frequently co-mentor trainees. TRAINEES: This program accepts trainees who are either board eligible in internal medicine (66-75% of trainees) and/or have a PhD in a biomedical field (25-33% of trainees). Special efforts are made annually to recruit minority candidates. TRAINING PROGRAMS: Trainees will have the opportunity to train in one of the participating unit laboratories. Each unit has been structured to be seamlessly integrated with institutional core facilities so that translational research can be performed at the highest level. A comprehensive training program that includes didactic lectures, research seminars, technology seminars, journal clubs, cell biology courses and hands on training in research is provided. Mandatory training in research integrity and grant writing are also provided. Each trainee is under the direct supervision of a primary mentor with additional content/career co-mentors. The need for research training, the strong record of this program and continued research strengths of this program form the basis for this application for renewal of this T-32 training grant.

Public Health Relevance

A comprehensive training program that includes didactic lectures, research seminars, technology seminars, journal clubs, cell biology courses and hands on training in research to preprare postdoctoral candidates for leadership roles in academic gastroenterology. There are five major participating units with a total of 25 participating faculty who are independently funded and have extensive collaborative networks with faculty members who also frequently co-mentor trainees. The five units are: (1) Enteric neuro-muscular and epithelial biology, (2) Hepatobiliary lipids, (3) GI cancer, (4) Clinical-Translational and (5) Alcohol related disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007150-38
Application #
8690820
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1976-07-01
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
38
Fiscal Year
2014
Total Cost
$326,579
Indirect Cost
$24,332
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Stewart, Karen E; Haller, Deborah L; Sargeant, Carol et al. (2015) Readiness for behaviour change in non-alcoholic fatty liver disease: implications for multidisciplinary care models. Liver Int 35:936-43
Stewart, Karen E; Hart, Robert P; Gibson, Douglas P et al. (2014) Illness apprehension, depression, anxiety, and quality of life in liver transplant candidates: implications for psychosocial interventions. Psychosomatics 55:650-8
Patidar, Kavish R; Sydnor, Malcolm; Sanyal, Arun J (2014) Transjugular intrahepatic portosystemic shunt. Clin Liver Dis 18:853-76
Satapathy, Sanjaya K; Sanyal, Arun J (2014) Nonendoscopic management strategies for acute esophagogastric variceal bleeding. Gastroenterol Clin North Am 43:819-33
Aleman, Jose O; Eusebi, Leonardo H; Ricciardiello, Luigi et al. (2014) Mechanisms of obesity-induced gastrointestinal neoplasia. Gastroenterology 146:357-73
Min, Hae-Ki; Sookoian, Silvia; Pirola, Carlos J et al. (2014) Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells. Am J Physiol Gastrointest Liver Physiol 307:G66-76
Bhogal, Harjit K; Sanyal, Arun J (2013) The molecular pathogenesis of cholestasis in sepsis. Front Biosci (Elite Ed) 5:87-96
Ridlon, Jason M; Hylemon, Phillip B (2012) Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7?-dehydroxylating intestinal bacterium. J Lipid Res 53:66-76
Nguyen, Tuyet A T; Sanyal, Arun J (2012) Pathophysiology guided treatment of nonalcoholic steatohepatitis. J Gastroenterol Hepatol 27 Suppl 2:58-64
Bhogal, Harjit K; Sanyal, Arun J (2011) Using transjugular intrahepatic portosystemic shunts for complications of cirrhosis. Clin Gastroenterol Hepatol 9:936-46; quiz e123

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