This is an application for continuation of the postdoctoral training program in nephrology research at the University of Texas Southwestern Medical Center. The program provides research training for adult and pediatric nephrology fellows as well as basic scientists who are conducting research related to the kidney. The primary purpose of the program remains the training of physician-scientists who will investigate kidney biology and disease and translate this knowledge into improvements in patient care. The training program has been continuously funded for the past 30 years. The applicant pool is robust, and the program has filled in each year of the match. The graduates from the program have published important contributions to biomedical research, and many have obtained faculty positions and received external funding for their research. The program faculty comprises 21 physician-scientists and basic scientists with expertise in a broad range of scientific disciplines that are relevant to the kidney. The training program is organized into three programs in basic science research (Renal Physiology &Cell Biology, Pathophysiology of Renal Disease, and Genetics &Development) and three programs in patient-oriented research (Chronic Kidney Disease, Hypertension &Cardiovascular Disease, and Mineral Metabolism). Each program includes clinical and basic science faculty and a formal didactic curriculum that includes required courses in ethics and the responsible conduct of research. The curriculum for basic science research also includes special topics in career development, a journal club, and elective courses at the Southwestern Graduate School of Biomedical Sciences. The curriculum for patient- oriented research consists of a certification program in patient-oriented research and a Masters Degree in Clinical Science. Trainees in the program also benefit from the Educational Enrichment Program provided by the UT Southwestern George M. O'Brien Kidney Research Core Center, which includes a biweekly research conference, annual symposium, and hands-on instruction in mouse models, small animal physiology, cell biology and pathology, and clinical and translational research.

Public Health Relevance

The goal of the UT Southwestern Nephrology Training Program is to provide research training for adult and pediatric nephrology fellows who will pursue careers in academic medicine and discover new knowledge that will advance our understanding of the causes and treatment of kidney disease. To achieve this goal, the program provides an intensive 2-3 year experience in basic and/or clinical research supplemented by formal didactic instruction in biomedical sciences, career development, and ethics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007257-32
Application #
8495314
Study Section
Special Emphasis Panel (ZDK1-GRB-G (J2))
Program Officer
Rys-Sikora, Krystyna E
Project Start
1977-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
32
Fiscal Year
2013
Total Cost
$336,087
Indirect Cost
$23,229
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Lakhia, Ronak; Hajarnis, Sachin; Williams, Darren et al. (2016) MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease. J Am Soc Nephrol 27:2319-30
Wu, Tianfu; Ding, Huihua; Han, Jie et al. (2016) Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study. J Proteome Res 15:2102-14
Ravikumar, Priya; Li, Liping; Ye, Jianfeng et al. (2016) αKlotho deficiency in acute kidney injury contributes to lung damage. J Appl Physiol (1985) 120:723-32
Arriens, Cristina; Chen, Sixia; Karp, David R et al. (2016) Prognostic significance of repeat biopsy in lupus nephritis: Histopathologic worsening and a short time between biopsies is associated with significantly increased risk for end stage renal disease and death. Clin Immunol :
Orme, Jacob J; Du, Yong; Vanarsa, Kamala et al. (2016) Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE. Clin Immunol 169:58-68
Tanriover, Bekir; Lakhia, Ronak; Shen, Yu-Min et al. (2015) Characteristics and Outcomes of Renal Transplant Recipients with Hemolytic Uremic Syndrome in the United States. Transplant Direct 1:
Arriens, Cristina; Hynan, Linda S; Lerman, Robert H et al. (2015) Placebo-controlled randomized clinical trial of fish oil's impact on fatigue, quality of life, and disease activity in Systemic Lupus Erythematosus. Nutr J 14:82
Gattineni, Jyothsna; Baum, Michel (2015) Developmental changes in renal tubular transport-an overview. Pediatr Nephrol 30:2085-98
Wu, Yipin; Baum, Michel; Huang, Chou-Long et al. (2015) Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function. Am J Physiol Regul Integr Comp Physiol 309:R747-56
Hutcheson, J; Ye, Y; Han, J et al. (2015) Resistin as a potential marker of renal disease in lupus nephritis. Clin Exp Immunol 179:435-43

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