This is an application for renewal of a longstanding program to provide intensive training in modern methods of nephrologic research to clinically trained individuals with the M.D. or M.D./Ph.D. degree. Continued funding of seven stipends per year is requested for this joint training program that provides support for both """"""""adult"""""""" and pediatric nephrology fellows. Although the highest priority of this program is to train physician-scientists, basic scientist trainees with the Ph.D. degree who are strongly committed to careers in kidney research are also supported whenever possible. Each year 3-4 new trainees are recruited into the program after completing residency training in internal medicine or pediatrics. Only fellows with a strong commitment to multi-year research training are recruited into the program. Training is provided in both laboratory-based and patient-oriented research. The training faculty is drawn from multiple clinical and basic science departments (Internal Medicine, Pediatrics, Biomedical Engineering, Cellular and Molecular Physiology, Cell Biology, Epidemiology and Public Health, Genetics, Immunobiology, Pathology, Pharmacology) and spans diverse biomedical disciplines relevant to kidney disease research (electrolyte physiology and pathophysiology, cell biology and experimental pathology, genetics and developmental biology, immunology and transplantation, vascular biology, tissue engineering, and clinical epidemiology and biostatistics). Although the core of research training is provided through work on a selected research topic under the supervision of an individual preceptor, training is enhanced by a broad array of teaching conferences, seminars and courses. Indeed, many recent fellows have enrolled in graduate degree programs specifically designed for training clinician investigators including the Investigative Medicine Ph.D. program, and the Program in Chronic Disease Epidemiology that leads to a Master of Science in Epidemiology and Public Health. Over the past 35 years this program has trained many leaders in academic nephrology, and the recent track record continues to be outstanding. The overwhelming majority of trainees who completed training during the past 10 years currently hold either full-time academic positions or research-related positions in industry, and many have successfully competed for career development faculty grants from the NIH or American Heart Association (e.g. K08, K23, Fellow-to-Faculty Transition Award) or have already obtained NIH R01 grants. The program also has made progress in achieving ethnic diversity, as four current fellows are underrepresented minority trainees.
Kidney diseases have an enormous impact on the health of Americans and on our nation's health care costs. The goal of the proposed program is to train physician-scientists and basic scientists for academic and research careers dedicated to understanding the mechanisms that cause kidney diseases and to developing new strategies for the prevention and treatment of kidney diseases.
|Schaub, Jennifer A; Parikh, Chirag R; TRIBE-AKI Consortium (2016) The Authors Reply. Kidney Int 89:1162-3|
|Reese, Peter P; Hall, Isaac E; Weng, Francis L et al. (2016) Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes. J Am Soc Nephrol 27:1534-43|
|Potluri, Vishnu S; Parikh, Chirag R; Hall, Isaac E et al. (2016) Validating Early Post-Transplant Outcomes Reported for Recipients of Deceased Donor Kidney Transplants. Clin J Am Soc Nephrol 11:324-31|
|Parikh, C R; Hall, I E; Bhangoo, R S et al. (2016) Associations of Perfusate Biomarkers and Pump Parameters With Delayed Graft Function and Deceased Donor Kidney Allograft Function. Am J Transplant 16:1526-39|
|Hassan, Hossam; Tian, Xuefei; Inoue, Kazunori et al. (2016) Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes. J Am Soc Nephrol 27:1055-65|
|Golden, D; Cantley, L G (2015) Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm. Oncogene 34:4702-12|
|Schaub, Jennifer A; Coca, Steven G; Moledina, Dennis G et al. (2015) Amino-Terminal Pro-B-Type Natriuretic Peptide forÂ Diagnosis and Prognosis in Patients With RenalÂ Dysfunction: A Systematic Review and Meta-Analysis. JACC Heart Fail 3:977-89|
|Huen, Sarah C; Huynh, Larry; Marlier, Arnaud et al. (2015) GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol 26:1334-45|
|Fedeles, Sorin V; So, Jae-Seon; Shrikhande, Amol et al. (2015) Sec63 and Xbp1 regulate IRE1Î± activity and polycystic disease severity. J Clin Invest 125:1955-67|
|Hall, I E; SchrÃ¶ppel, B; Doshi, M D et al. (2015) Associations of deceased donor kidney injury with kidney discard and function after transplantation. Am J Transplant 15:1623-31|
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