This competitive renewal of a Training Program in Diabetes and Metabolism (DK07352) was combined in 1988 from programs in Endocrinology funded in 1968 (DK07147) and Diabetes and Metabolism funded in 1979 (DK07352). The Program provides postdoctoral research training in Diabetes and Metabolism for individuals with MD or PhD degrees, preparing trainees for academic careers as independent investigators and provides up to three years of laboratory research training. The faculty consist of 18 investigators funded with NIH R01 grants and/or other funds, 3 junior faculty members, who are developing independent programs and have some form of support, and 58 adjunct faculty in both basic science and clinical departments. The Program is designed to provide trainees with: (i) all components of the scientific method, (ii) a focused approach to scientific investigation, (iii) experience with the most modern analytical tools and methodologies, (iv) grant writing skills, and (v) capability to develop as independent biomedical research scientists. The components of the Program include formal didactic course work, seminars and conferences, intra- and extra-mural scientific presentations, a focused research experience in the laboratories of established investigators, and grant writing. The Program is administered by the Steering Committee, chaired by the Program Director, which is responsible for the trainees' appointment and laboratory assignment, development of didactic curricula, review of trainees' initial project, and annual review of trainees' progress. Of particular note in the Program are the focused approach to training goals for each laboratory-based trainee, a strong commitment to provide maximal training duration, the uniform extramural funding of the independent investigators that serve as primary faculty, the productive training record of the training program, the presence of an enthusiastic and knowledgeable junior training faculty, the availability of adjunct faculty whose primary areas of basic science and/or clinical investigation are intimately tied to those of metabolism, diabetes and endocrinology, and the diversity of the faculty research programs which range from molecular endocrinology to clinical research. Due to the program's popularity and success and the large amount of research funds awarded to our highly qualified faculty, we request to continue our program at the current level of 6 fellowship slots.

Public Health Relevance

This application is for renewal of a Training Program in Diabetes and Metabolism that has been funded for the last 35 years. The Program provides postdoctoral research training in Diabetes and Metabolism for 6 individuals for a maximum of three years. Trainees must have MD, PhD, or MD/PhD degrees. The program prepares trainees for academic careers as independent investigators. Trainees work in the laboratories of 18 investigators, who have extramural funds to support their research programs and who use the latest technologies. The Program is designed to provide trainees with a thorough understanding of the scientific method, a focused approach to scientific investigation, experience with the lates analytical tools and methodologies, grant writing skills, and capability to develop as independent biomedical research scientists. The program's goal is to provide the next generation of highly qualified researchers, who will continue to improve our ability to provide state-of-the-art diagnosis and treatment of patients with endocrine disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007352-37
Application #
8867218
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1979-07-19
Project End
2019-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
37
Fiscal Year
2015
Total Cost
$293,611
Indirect Cost
$27,153
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Schulze, Ryan J; Dri┼żyt?, Kristina; Casey, Carol A et al. (2017) Hepatic Lipophagy: New Insights into Autophagic Catabolism of Lipid Droplets in the Liver. Hepatol Commun 1:359-369
Schulze, Ryan J; Sathyanarayan, Aishwarya; Mashek, Douglas G (2017) Breaking fat: The regulation and mechanisms of lipophagy. Biochim Biophys Acta 1862:1178-1187
Robinson, Matthew M; Dasari, Surendra; Konopka, Adam R et al. (2017) Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans. Cell Metab 25:581-592
Lu, Jin; Varghese, Ron T; Zhou, Lianzhen et al. (2017) Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146. Metabolism 68:55-63
Morgan-Bathke, Maria; Harteneck, Debra; Jaeger, Philippa et al. (2017) Comparison of Methods for Analyzing Human Adipose Tissue Macrophage Content. Obesity (Silver Spring) 25:2100-2107
Schott, Micah B; Rasineni, Karuna; Weller, Shaun G et al. (2017) ?-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure. J Biol Chem 292:11815-11828
Konopka, Adam R; Esponda, Raul Ruiz; Robinson, Matthew M et al. (2016) Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes. Cell Rep 15:1394-1400
Li, Zhipeng; Schulze, Ryan J; Weller, Shaun G et al. (2016) A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Sci Adv 2:e1601470
Varghese, Ron T; Dalla Man, Chiara; Sharma, Anu et al. (2016) Mechanisms Underlying the Pathogenesis of Isolated Impaired Glucose Tolerance in Humans. J Clin Endocrinol Metab 101:4816-4824
Johnson, Matthew L; Distelmaier, Klaus; Lanza, Ian R et al. (2016) Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults. Diabetes 65:74-84

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