The goal of this training program is to provide basic laboratory, translational, or clinical research training for physicians who have completed clinical training in gastroenterology in preparation for careers as independent investigators in academic hepatology and to provide research training for recent Ph.D. graduates to prepare them for careers as independent investigators in basic liver-related research. Physicians will be supported for three years and Ph.D. trainees for two years. Selection of trainees will be based on strong prior research experience and commitment to liver-related research. This training program will use the combined resources of the Yale Section of Digestive Diseases, the NIH funded Yale Liver Center and facilities of the participating faculty including the Departments of Internal Medicine, Cell Biology, Cellular and Molecular Physiology, Human Genetics, Laboratory Medicine, Pediatrics, and Pharmacology. The major research areas represented include 1) cellular, molecular, developmental, and stem cell biology of the liver, 2) signal transduction mechanisms in the liver, 3) hepatic metabolism, 4) regulation and control of the splanchnic circulation, 5) infection, inflammation, immunity, and fibrosis in the liver and 6) genetic approaches to liver disease. A strong educational curriculum is provided by the Section of Digestive Diseases and the Medical School's Investigative Medicine Program as well as enrichment programs provided by the Liver Center. Trainees are encouraged to audit or enroll in specific courses in the School of Medicine or the School of Public Health, attend an annual laboratory and lecture course designed for physician trainees in the Department of Medicine, and are required to attend both the Hepatology and Basic Science Journal Clubs, and twice weekly research and path physiology seminars. Progress is monitored through several mechanisms including """"""""Research in Progress"""""""" seminars and individual Progress Committees.
Liver disease is a leading cause of morbidity and mortality among Americans. There is a need to better understand the causes of liver diseases and develop improved treatments. This grant seeks funds to train physicians and scientists to investigate the causes of liver disease and to develop improved treatments.
|Li, Hua-Bing; Tong, Jiyu; Zhu, Shu et al. (2017) m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature 548:338-342|
|McCarty, Thomas R; Sack, Jordan; Syed, Bakhtiar et al. (2017) Fungal endotipsitis: A case report and literature review. J Dig Dis 18:237-240|
|Bakhit, Mena; McCarty, Thomas R; Park, Sunhee et al. (2017) Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review. World J Gastroenterol 23:366-372|
|Tse, Chung Sang; Parikh, Neil D (2017) An uncommon source of upper gastrointestinal bleeding: epiphrenic esophageal diverticulum. Gastroenterol Rep (Oxf) 5:313-315|
|McCarty, Thomas R; Afinogenova, Yuliya; Njei, Basile (2017) Use of Wireless Capsule Endoscopy for the Diagnosis and Grading of Esophageal Varices in Patients With Portal Hypertension: A Systematic Review and Meta-Analysis. J Clin Gastroenterol 51:174-182|
|Njei, Basile; McCarty, Thomas R; Laine, Loren (2017) Early transjugular intrahepatic portosystemic shunt in US patients hospitalized with acute esophageal variceal bleeding. J Gastroenterol Hepatol 32:852-858|
|Kolodecik, Thomas R; Reed, Anamika M; Date, Kimie et al. (2017) The serum protein renalase reduces injury in experimental pancreatitis. J Biol Chem 292:21047-21059|
|Njei, Basile; McCarty, Thomas R; Varadarajulu, Shyam et al. (2017) Cost utility of ERCP-based modalities for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis. Gastrointest Endosc 85:773-781.e10|
|McCarty, Thomas R; Njei, Basile (2016) Trends in malignant intraductal papillary mucinous neoplasm in US adults from 1990 to 2010: a SEER database analysis. Gastroenterol Rep (Oxf) 4:113-8|
|Bakhit, Mena; McCarty, Thomas R; Park, Sunhee et al. (2016) Vanishing Bile Duct Syndrome in Hodgkin's Lymphoma: A Single Center Experience and Clinical Pearls. J Clin Gastroenterol 50:688|
Showing the most recent 10 out of 82 publications