The goal of this training program is to provide basic laboratory, translational, or clinical research training for physicians who have completed clinical training in gastroenterology in preparation for careers as independent investigators in academic hepatology and to provide research training for recent Ph.D. graduates to prepare them for careers as independent investigators in basic liver-related research. Physicians will be supported for two to three years and Ph.D. trainees for two years. Selection of trainees will be based on strong prior research experience and commitment to liver-related research. This training program will use the combined resources of the Yale Section of Digestive Diseases, the NIH funded Yale Liver Center and facilities of the participating faculty including the Departments of Internal Medicine, Cell Biology, Cellular and Molecular Physiology, Human Genetics, Microbial Pathogenesis, Pediatrics, and Pharmacology. The major research areas represented include 1) cellular, molecular, and developmental biology of the liver, 2) signal transduction mechanisms in the liver, 3) hepatic metabolism, 4) infection, inflammation, immunity, and fibrosis in the liver, 5) genetic approaches to liver disease and 6) clinical investigation of liver disease. The Section of Digestive Diseases, the Medical School's Investigative Medicine Program as well as enrichment programs provided by the Liver Center together provide a strong educational curriculum. Trainees are encouraged to audit or enroll in specific courses in the School of Medicine or the School of Public Health, attend an annual laboratory and lecture course designed for physician trainees in the Department of Medicine, and are required to attend both the Hepatology and Basic Science Journal Clubs, plus twice weekly research and pathophysiology seminars. Progress is monitored through several mechanisms including """"""""Research in Progress"""""""" seminars and individual Progress Committees.

Public Health Relevance

Liver disease affects one in four Americans and over half a billion people worldwide. The purpose of this grant is to provide training to physicians and other scientists to pursue basic, translational and clinical research into the causes of the various forms of liver disease and to develop new and more effective treatments.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
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Yale University
Internal Medicine/Medicine
Schools of Medicine
New Haven
United States
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Edmunds, Catherine; Ekong, Udeme D (2016) Autoimmune Liver Disease Post-Liver Transplantation: A Summary and Proposed Areas for Future Research. Transplantation 100:515-24
Bakhit, Mena; McCarty, Thomas R; Park, Sunhee et al. (2016) Vanishing Bile Duct Syndrome in Hodgkin's Lymphoma: A Single Center Experience and Clinical Pearls. J Clin Gastroenterol 50:688
Cao, Guangchao; Li, Hua-Bing; Yin, Zhinan et al. (2016) Recent advances in dynamic m6A RNA modification. Open Biol 6:160003
Clark, Brian T; Parikh, Neil D; Laine, Loren (2016) Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy. Gastrointest Endosc 84:126-32
Njei, Basile; McCarty, Thomas R; Luk, Jeffrey et al. (2016) Use of transient elastography in patients with HIV-HCV coinfection: A systematic review and meta-analysis. J Gastroenterol Hepatol 31:1684-1693
McCarty, Thomas R; Njei, Basile (2016) Self-expanding metal stents for acute refractory esophageal variceal bleeding: A systematic review and meta-analysis. Dig Endosc 28:539-47
Shin, Dongsuk; Lee, Michelle H; Polydorides, Alexandros D et al. (2016) Quantitative analysis of high-resolution microendoscopic images for diagnosis of neoplasia in patients with Barrett's esophagus. Gastrointest Endosc 83:107-14
Popov, Violeta B; Jornayvaz, Francois R; Akgul, Emin O et al. (2016) Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance. FASEB J 30:1207-17
Sarkar, Souvik; Esserman, Denise A; Skanderson, Melissa et al. (2016) Disparities in hepatitis C testing in U.S. veterans born 1945-1965. J Hepatol 65:259-65
Njei, Basile; McCarty, Thomas R; Birk, John W (2016) Trends in esophageal cancer survival in United States adults from 1973 to 2009: A SEER database analysis. J Gastroenterol Hepatol 31:1141-6

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