The goal of this training program is to provide basic laboratory, translational, or clinical research training for physicians who have completed clinical training in gastroenterology in preparation for careers as independent investigators in academic hepatology and to provide research training for recent Ph.D. graduates to prepare them for careers as independent investigators in basic liver-related research. Physicians will be supported for two to three years and Ph.D. trainees for two years. Selection of trainees will be based on strong prior research experience and commitment to liver-related research. This training program will use the combined resources of the Yale Section of Digestive Diseases, the NIH funded Yale Liver Center and facilities of the participating faculty including the Departments of Internal Medicine, Cell Biology, Cellular and Molecular Physiology, Human Genetics, Microbial Pathogenesis, Pediatrics, and Pharmacology. The major research areas represented include 1) cellular, molecular, and developmental biology of the liver, 2) signal transduction mechanisms in the liver, 3) hepatic metabolism, 4) infection, inflammation, immunity, and fibrosis in the liver, 5) genetic approaches to liver disease and 6) clinical investigation of liver disease. The Section of Digestive Diseases, the Medical School's Investigative Medicine Program as well as enrichment programs provided by the Liver Center together provide a strong educational curriculum. Trainees are encouraged to audit or enroll in specific courses in the School of Medicine or the School of Public Health, attend an annual laboratory and lecture course designed for physician trainees in the Department of Medicine, and are required to attend both the Hepatology and Basic Science Journal Clubs, plus twice weekly research and pathophysiology seminars. Progress is monitored through several mechanisms including """"""""Research in Progress"""""""" seminars and individual Progress Committees.
Liver disease affects one in four Americans and over half a billion people worldwide. The purpose of this grant is to provide training to physicians and other scientists to pursue basic, translational and clinical research into the causes of the various forms of liver disease and to develop new and more effective treatments.
|Hung, Adelina; Garcia-Tsao, Guadalupe (2018) Acute kidney injury, but not sepsis, is associated with higher procedure-related bleeding in patients with decompensated cirrhosis. Liver Int 38:1437-1441|
|Parikh, Neil D; Viana, Artur V; Shah, Saloni et al. (2018) Image-enhanced endoscopy is specific for the diagnosis of non-erosive gastroesophageal reflux disease. Scand J Gastroenterol 53:260-264|
|Njei, Basile; McCarty, Thomas R; Sharma, Prabin et al. (2018) Bariatric Surgery and Hepatocellular Carcinoma: a Propensity Score-Matched Analysis. Obes Surg 28:3880-3889|
|Sharma, Prabin; McCarty, Thomas R; Ngu, Julius N et al. (2018) Impact of bariatric surgery in patients with HIV infection: a nationwide inpatient sample analysis, 2004-2014. AIDS 32:1959-1965|
|Franca, Andressa; Filho, Antonio Carlos Melo Lima; Guerra, Mateus T et al. (2018) Effects of endotoxin on type 3 inositol 1,4,5-trisphosphate receptor in human cholangiocytes. Hepatology :|
|McConnell, Matthew; Iwakiri, Yasuko (2018) Biology of portal hypertension. Hepatol Int 12:11-23|
|Kolodecik, Thomas R; Reed, Anamika M; Date, Kimie et al. (2017) The serum protein renalase reduces injury in experimental pancreatitis. J Biol Chem 292:21047-21059|
|Li, Hua-Bing; Tong, Jiyu; Zhu, Shu et al. (2017) m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature 548:338-342|
|Bakhit, Mena; McCarty, Thomas R; Park, Sunhee et al. (2017) Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review. World J Gastroenterol 23:366-372|
|McCarty, Thomas R; Sack, Jordan; Syed, Bakhtiar et al. (2017) Fungal endotipsitis: A case report and literature review. J Dig Dis 18:237-240|
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