The goal of this training program is to provide basic laboratory, translational, or clinical research training for physicians who have completed clinical training in gastroenterology in preparation for careers as independent investigators in academic hepatology and to provide research training for recent Ph.D. graduates to prepare them for careers as independent investigators in basic liver-related research. Physicians will be supported for two to three years and Ph.D. trainees for two years. Selection of trainees will be based on strong prior research experience and commitment to liver-related research. This training program will use the combined resources of the Yale Section of Digestive Diseases, the NIH funded Yale Liver Center and facilities of the participating faculty including the Departments of Internal Medicine, Cell Biology, Cellular and Molecular Physiology, Human Genetics, Microbial Pathogenesis, Pediatrics, and Pharmacology. The major research areas represented include 1) cellular, molecular, and developmental biology of the liver, 2) signal transduction mechanisms in the liver, 3) hepatic metabolism, 4) infection, inflammation, immunity, and fibrosis in the liver, 5) genetic approaches to liver disease and 6) clinical investigation of liver disease. The Section of Digestive Diseases, the Medical School's Investigative Medicine Program as well as enrichment programs provided by the Liver Center together provide a strong educational curriculum. Trainees are encouraged to audit or enroll in specific courses in the School of Medicine or the School of Public Health, attend an annual laboratory and lecture course designed for physician trainees in the Department of Medicine, and are required to attend both the Hepatology and Basic Science Journal Clubs, plus twice weekly research and pathophysiology seminars. Progress is monitored through several mechanisms including "Research in Progress" seminars and individual Progress Committees.

Public Health Relevance

Liver disease affects one in four Americans and over half a billion people worldwide. The purpose of this grant is to provide training to physicians and other scientists to pursue basic, translational and clinical research into the causes of the various forms of liver disease and to develop new and more effective treatments.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007356-36
Application #
8661550
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1984-07-01
Project End
2019-07-31
Budget Start
2014-08-15
Budget End
2015-07-31
Support Year
36
Fiscal Year
2014
Total Cost
$252,133
Indirect Cost
$18,553
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
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Hoque, Rafaz; Farooq, Ahmad; Malik, Ahsan et al. (2013) A novel small-molecule enantiomeric analogue of traditional (-)-morphinans has specific TLR9 antagonist properties and reduces sterile inflammation-induced organ damage. J Immunol 190:4297-304
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Flach, Rachel J Roth; Qin, Hui; Zhang, Lei et al. (2011) Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27. J Biol Chem 286:22195-202
Bultron, Gilberto; Kacena, Katherine; Pearson, Daniel et al. (2010) The risk of Parkinson's disease in type 1 Gaucher disease. J Inherit Metab Dis 33:167-73

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