We seek renewal of the Case Western Reserve University (CWRU) Nephrology Training Program, which has been funded continuously for twenty-fouryears. Our goal is to train promising postdoctoral fellows who are committed to understanding normal kidney function and the pathogenesis of kidney disease as independent investigators . Support is requested for three postdoctoral, board-eligible or board-certified internists and/or pediatricians, or basic scientists (Ph.D., M.D. or M.D./Ph.D.) for two or more years of research training. Normally, 1-2 new trainees enter the program each year. The principal training mechanism is performance of research under the supervision of one or more of the primary trainingfaculty. This group is highly interactive and collaborative, and consists of 14 investigators in the adult or pediatric Divisions of Nephrology and 17 other clinical and basic scientists, all of whom actively study kidney biology and disease. The training faculty are based in six departments, Medicine, Pediatrics, Pathology, Physiology, Pharmacology and Epidemiology/Biostatistics at the School of Medicine. Research interests of the primary faculty include glomerular development and disease, epithelial cell biology and ion transport, genetic epidemiology, health services research and clinical trials. Research faculty apply cellular, molecular biological, genetic, genomic and epidemiological methods to in vitro models, animal models and/or patients. Faculty laboratories contain over 20,000 square feet of state-of-the-art space. The resources of the CWRU Clinical and Translational Collaborative are available for patient-oriented research. Training also includes lectures, weekly seminars and, if appropriate, course work (formal degree programs or individual classes). Trainees frequently present their work in local seminars attended by faculty and other trainees as well as at national meetings. Career mentoring is an integral aspect of the program. A formal mechanism of administration, governance and program evaluation is in place to assure program quality.This program offers nephrology and basic scientist postdoctoral fellows an interdisciplinarytrainingprogram in state-of-the-art experimental approaches to define normal kidney physiology and mechanisms of disease within the rich, research environment of the CWRU School of Medicine.

Public Health Relevance

The prevalence of end stage renal disease is approximately 1500 per million population in the United States and approximately 2 to 3% of the U.S. population has abnormal kidney filtration function. Prevalence of CKD in the United States in 1999-2004 is higher than it was in 1988-1994. Trainees supported by this program will develop into independent investigators focused on reducing kidney disease burden in theU.S.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S (J2))
Program Officer
Rys-Sikora, Krystyna E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Case Western Reserve University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Zhang, Liqun; Centa, Thomas; Buck, Matthias (2014) Structure and dynamics analysis on plexin-B1 Rho GTPase binding domain as a monomer and dimer. J Phys Chem B 118:7302-11
Zerbetto, Mirco; Anderson, Ross; Bouguet-Bonnet, Sabine et al. (2013) Analysis of 15N-1H NMR relaxation in proteins by a combined experimental and molecular dynamics simulation approach: picosecond-nanosecond dynamics of the Rho GTPase binding domain of plexin-B1 in the dimeric state indicates allosteric pathways. J Phys Chem B 117:174-84
Dobre, Mirela; Meyer, Timothy W; Hostetter, Thomas H (2013) Searching for uremic toxins. Clin J Am Soc Nephrol 8:322-7
Zhang, Liqun; Sodt, Alexander J; Venable, Richard M et al. (2013) Prediction, refinement, and persistency of transmembrane helix dimers in lipid bilayers using implicit and explicit solvent/lipid representations: microsecond molecular dynamics simulations of ErbB1/B2 and EphA1. Proteins 81:365-76
Ferrell, Nicholas; Cameron, Kathleen O; Groszek, Joseph J et al. (2013) Effects of pressure and electrical charge on macromolecular transport across bovine lens basement membrane. Biophys J 104:1476-84
Huml, Anne M; Sullivan, Catherine M; Pencak, Julie A et al. (2013) Accuracy of dialysis medical records in determining patients' interest in and suitability for transplantation. Clin Transplant 27:541-5
Ferrell, Nicholas; Ricci, Kevin B; Groszek, Joseph et al. (2012) Albumin handling by renal tubular epithelial cells in a microfluidic bioreactor. Biotechnol Bioeng 109:797-803
Kim, Jane H; Mukherjee, Amitava; Madhavan, Sethu M et al. (2012) WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization. Am J Physiol Renal Physiol 302:F103-15
Sedor, John R; Madhavan, Sethu M; Kim, Jane H et al. (2011) Out on a LIM: chronic kidney disease, podocyte phenotype and the Wilm's tumor interacting protein (WTIP). Trans Am Clin Climatol Assoc 122:184-97
Ferrell, Nicholas; Groszek, Joseph; Li, Lingyan et al. (2011) Basal lamina secreted by MDCK cells has size- and charge-selective properties. Am J Physiol Renal Physiol 300:F86-90

Showing the most recent 10 out of 38 publications