This is a revised competitive renewal proposal for the Training Program entitled: """"""""Training in Pediatric Gastroenterology and Nutrition"""""""". The overarching goal of the Training Program (entering its 30th year) is to prepare MD, MD/PhD pediatricians, and PhD basic scientists for careers in independent research on topics relevant to digestive diseases in infancy, childhood, and adult life. We offer training in 4 broad areas of Basic and Clinical/Translational science relevant to the Digestive Diseases: * Epithelial/Neuro-endocrine Cell Biology/Physiology &Stem Cell and Developmental Biology;* Innate and Adaptive Mucosal Immunology;* Microbiology, Microbial Pathogenesis, and the Gut Microbiome;and * Clinical/Translational research. The program provides an in depth comprehensive scientific experience for each trainee in a research group at the forefront of its field. Seven postdoctoral positions are requested for 2-3 years of research training. 60 core reseach faculty support this effort. Training faculty are drawn from all Harvard Affiliated Hospitals and Research Institutes, the Harvard Medical School, and the Harvard School of Public Health. Opportunities for cross-fertilization are abundant. The Program Director is Dr. Wayne I. Lencer MD, Professor of Pediatrics, Harvard Medical School, a widely respected investigator and mentor. Dr. Scott Snapper MD PhD, Associate Professor HMS and highly accomplished investigator will act as co-director for the pre-doctoral program in mucosal immunology. A Mentoring Program and Scholarship Oversight Committee (SOC) or Dissertation Advisory Committee (DAC), led by Drs. Lencer, Snapper, and two accomplished and well respected previously NIH-funded HMS Professors (Marian Neutra PhD and Richard Grand MD), are assembled for each trainee to provide mentoring and oversight in scientific and career development. Didactic course work is required for both basic and clinical research training tracks and supplemented with relevant seminars and journal clubs, a course in the responsible conduct of research, and an annual research retreat. Trainees in clinical research must obtain a Master's Degree in Medical Science or Public Heath (MMSc or MPH) from the Harvard Medical School or Harvard School of Public Health. Integration of training with the candidates'future goals in academic medicine, a strong focus on original research, and strong mentoring in science and career development are essential features of the program.

Public Health Relevance

The goal of this application is to prepare MD, MD/PhD pediatricians, and PhD basic scientists for careers in independent research on topics relevant to digestive diseases in infancy, childhood, and adult life. Post- doctoral training in both basic and clinical research relevant to the GI tract is provided. The training program is relevant to clinica and basic research in the field and will continue its 30 years of accomplishments to train leaders in academic medicine relevant to the digestive diseases and mucosal immunology, epithelial biology, infection gut microbial ecology, and host defense.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007477-31A1
Application #
8663358
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1983-12-01
Project End
2019-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
31
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Hron, Bridget M; Ebbeling, Cara B; Feldman, Henry A et al. (2017) Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism. Nutr Metab (Lond) 14:44
Gosselin, Kerri B; Aboud, Said; McDonald, Christine M et al. (2017) Etiology of Diarrhea, Nutritional Outcomes, and Novel Intestinal Biomarkers in Tanzanian Infants. J Pediatr Gastroenterol Nutr 64:104-108
Fiechtner, Lauren; Cheng, Erika R; Lopez, Gabriel et al. (2017) Multilevel Correlates of Healthy BMI Maintenance and Return to a Healthy BMI among Children in Massachusetts. Child Obes 13:146-153
Frank, S R; Köllmann, C P; van Lidth de Jeude, J F et al. (2017) The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene 36:1816-1828
Gluchowski, Nina L; Chitraju, Chandramohan; Picoraro, Joseph A et al. (2017) Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J Lipid Res 58:1230-1237
Mahoney, Lisa; Rosen, Rachel (2017) Feeding Problems and Their Underlying Mechanisms in the Esophageal Atresia-Tracheoesophageal Fistula Patient. Front Pediatr 5:127
Storm, Andrew C; Thompson, Christopher C (2016) Endoscopic management of sump syndrome resulting from endoscopic choledochogastrostomy. Gastrointest Endosc 83:1037
Saslowsky, David E; Thiagarajah, Jay R; McCormick, Beth A et al. (2016) Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Mol Biol Cell 27:1120-30
Hatzios, Stavroula K; Abel, Sören; Martell, Julianne et al. (2016) Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol 12:268-274
Akula, Murali K; Shi, Man; Jiang, Zhaozhao et al. (2016) Control of the innate immune response by the mevalonate pathway. Nat Immunol 17:922-9

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