This is a revised competitive renewal proposal for the Training Program entitled: "Training in Pediatric Gastroenterology and Nutrition". The overarching goal of the Training Program (entering its 30th year) is to prepare MD, MD/PhD pediatricians, and PhD basic scientists for careers in independent research on topics relevant to digestive diseases in infancy, childhood, and adult life. We offer training in 4 broad areas of Basic and Clinical/Translational science relevant to the Digestive Diseases: * Epithelial/Neuro-endocrine Cell Biology/Physiology &Stem Cell and Developmental Biology;* Innate and Adaptive Mucosal Immunology;* Microbiology, Microbial Pathogenesis, and the Gut Microbiome;and * Clinical/Translational research. The program provides an in depth comprehensive scientific experience for each trainee in a research group at the forefront of its field. Seven postdoctoral positions are requested for 2-3 years of research training. 60 core reseach faculty support this effort. Training faculty are drawn from all Harvard Affiliated Hospitals and Research Institutes, the Harvard Medical School, and the Harvard School of Public Health. Opportunities for cross-fertilization are abundant. The Program Director is Dr. Wayne I. Lencer MD, Professor of Pediatrics, Harvard Medical School, a widely respected investigator and mentor. Dr. Scott Snapper MD PhD, Associate Professor HMS and highly accomplished investigator will act as co-director for the pre-doctoral program in mucosal immunology. A Mentoring Program and Scholarship Oversight Committee (SOC) or Dissertation Advisory Committee (DAC), led by Drs. Lencer, Snapper, and two accomplished and well respected previously NIH-funded HMS Professors (Marian Neutra PhD and Richard Grand MD), are assembled for each trainee to provide mentoring and oversight in scientific and career development. Didactic course work is required for both basic and clinical research training tracks and supplemented with relevant seminars and journal clubs, a course in the responsible conduct of research, and an annual research retreat. Trainees in clinical research must obtain a Master's Degree in Medical Science or Public Heath (MMSc or MPH) from the Harvard Medical School or Harvard School of Public Health. Integration of training with the candidates'future goals in academic medicine, a strong focus on original research, and strong mentoring in science and career development are essential features of the program.

Public Health Relevance

The goal of this application is to prepare MD, MD/PhD pediatricians, and PhD basic scientists for careers in independent research on topics relevant to digestive diseases in infancy, childhood, and adult life. Post- doctoral training in both basic and clinical research relevant to the GI tract is provided. The training program is relevant to clinica and basic research in the field and will continue its 30 years of accomplishments to train leaders in academic medicine relevant to the digestive diseases and mucosal immunology, epithelial biology, infection gut microbial ecology, and host defense.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
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Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Densmore, Christine L
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Children's Hospital Boston
United States
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Hatzios, Stavroula K; Abel, Sören; Martell, Julianne et al. (2016) Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol 12:268-74
Storm, Andrew C; Thompson, Christopher C (2016) Endoscopic management of sump syndrome resulting from endoscopic choledochogastrostomy. Gastrointest Endosc 83:1037
Jirapinyo, Pichamol; Dayyeh, Barham K Abu; Thompson, Christopher C (2016) Gastrojejunal anastomotic reduction for weight regain in roux-en-y gastric bypass patients: physiological, behavioral, and anatomical effects of endoscopic suturing and sclerotherapy. Surg Obes Relat Dis 12:1810-1816
Schulman, Allison R; Aihara, Hiroyuki; Thompson, Christopher C (2016) Treatment of gastrocutaneous fistula after percutaneous gastrostomy placement. Gastrointest Endosc 84:851-852
Fiechtner, Lauren; Kleinman, Ken; Melly, Steven J et al. (2016) Effects of Proximity to Supermarkets on a Randomized Trial Studying Interventions for Obesity. Am J Public Health 106:557-62
Goettel, Jeremy A; Biswas, Subhabrata; Lexmond, Willem S et al. (2015) Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood 125:3886-95
Richmond, Camilla A; Shah, Manasvi S; Deary, Luke T et al. (2015) Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep 13:2403-11
Afzal, Amna Sadaf; Gortmaker, Steven (2015) The Relationship between Obesity and Cognitive Performance in Children: A Longitudinal Study. Child Obes 11:466-74
Hron, Bridget M; Ebbeling, Cara B; Feldman, Henry A et al. (2015) Relationship of insulin dynamics to body composition and resting energy expenditure following weight loss. Obesity (Silver Spring) 23:2216-22
Criss, Shaniece; Woo Baidal, Jennifer A; Goldman, Roberta E et al. (2015) The Role of Health Information Sources in Decision-Making Among Hispanic Mothers During Their Children's First 1000 Days of Life. Matern Child Health J 19:2536-43

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