This is a revised competitive renewal proposal for the Training Program entitled: "Training in Pediatric Gastroenterology and Nutrition". The overarching goal of the Training Program (entering its 30th year) is to prepare MD, MD/PhD pediatricians, and PhD basic scientists for careers in independent research on topics relevant to digestive diseases in infancy, childhood, and adult life. We offer training in 4 broad areas of Basic and Clinical/Translational science relevant to the Digestive Diseases: * Epithelial/Neuro-endocrine Cell Biology/Physiology &Stem Cell and Developmental Biology;* Innate and Adaptive Mucosal Immunology;* Microbiology, Microbial Pathogenesis, and the Gut Microbiome;and * Clinical/Translational research. The program provides an in depth comprehensive scientific experience for each trainee in a research group at the forefront of its field. Seven postdoctoral positions are requested for 2-3 years of research training. 60 core reseach faculty support this effort. Training faculty are drawn from all Harvard Affiliated Hospitals and Research Institutes, the Harvard Medical School, and the Harvard School of Public Health. Opportunities for cross-fertilization are abundant. The Program Director is Dr. Wayne I. Lencer MD, Professor of Pediatrics, Harvard Medical School, a widely respected investigator and mentor. Dr. Scott Snapper MD PhD, Associate Professor HMS and highly accomplished investigator will act as co-director for the pre-doctoral program in mucosal immunology. A Mentoring Program and Scholarship Oversight Committee (SOC) or Dissertation Advisory Committee (DAC), led by Drs. Lencer, Snapper, and two accomplished and well respected previously NIH-funded HMS Professors (Marian Neutra PhD and Richard Grand MD), are assembled for each trainee to provide mentoring and oversight in scientific and career development. Didactic course work is required for both basic and clinical research training tracks and supplemented with relevant seminars and journal clubs, a course in the responsible conduct of research, and an annual research retreat. Trainees in clinical research must obtain a Master's Degree in Medical Science or Public Heath (MMSc or MPH) from the Harvard Medical School or Harvard School of Public Health. Integration of training with the candidates'future goals in academic medicine, a strong focus on original research, and strong mentoring in science and career development are essential features of the program.
The goal of this application is to prepare MD, MD/PhD pediatricians, and PhD basic scientists for careers in independent research on topics relevant to digestive diseases in infancy, childhood, and adult life. Post- doctoral training in both basic and clinical research relevant to the GI tract is provided. The training program is relevant to clinica and basic research in the field and will continue its 30 years of accomplishments to train leaders in academic medicine relevant to the digestive diseases and mucosal immunology, epithelial biology, infection gut microbial ecology, and host defense.
|Yimlamai, Dean; Christodoulou, Constantina; Galli, Giorgio G et al. (2014) Hippo pathway activity influences liver cell fate. Cell 157:1324-38|
|Gosselin, Kerri B; Feldman, Henry A; Sonis, Andrew L et al. (2014) Serum citrulline as a biomarker of gastrointestinal function during hematopoietic cell transplantation in children. J Pediatr Gastroenterol Nutr 58:709-14|
|Demchev, Valeriy; Malana, Geraldine; Vangala, Divya et al. (2013) Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLoS One 8:e58084|
|Jacobson, Denise L; Bousvaros, Athos; Ashworth, Lori et al. (2013) Immunogenicity and tolerability to human papillomavirus-like particle vaccine in girls and young women with inflammatory bowel disease. Inflamm Bowel Dis 19:1441-9|
|Docktor, Michael J; Paster, Bruce J; Abramowicz, Shelly et al. (2012) Alterations in diversity of the oral microbiome in pediatric inflammatory bowel disease. Inflamm Bowel Dis 18:935-42|
|Zitomersky, Naamah Levy; Coyne, Michael J; Comstock, Laurie E (2011) Longitudinal analysis of the prevalence, maintenance, and IgA response to species of the order Bacteroidales in the human gut. Infect Immun 79:2012-20|
|Delgado-Borrego, A; Kamegaya, Y; Jordan, S H et al. (2011) HCV synergizes with body weight in the promotion of insulin resistance. J Viral Hepat 18:135-41|
|Steil, Garry M; Alexander, Jamin; Papas, Alexandra et al. (2011) Use of a continuous glucose sensor in an extracorporeal life support circuit. J Diabetes Sci Technol 5:93-8|
|Burpee, Tyler; Mitchell, Paul; Fishman, Douglas et al. (2011) Intestinal ferroportin expression in pediatric Crohn's disease. Inflamm Bowel Dis 17:524-31|
|Chiou, E; Rosen, R; Jiang, H et al. (2011) Diagnosis of supra-esophageal gastric reflux: correlation of oropharyngeal pH with esophageal impedance monitoring for gastro-esophageal reflux. Neurogastroenterol Motil 23:717-e326|
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