This is a competitive renewal application for the Hormones &Metabolism: Cells, Tissues, Animals &Humans established in 1985 under the direction of Dr. R. Suzanne Zukin, Program Director. For the past twenty years this program has provided multi-disciplinary training at the predoctoral and postdoctoral levels for research careers in diabetes (secretion from islets/genetically engineered beta cells, central and peripheral mechanisms of insulin resistance, diabetic complications, human genetics of diabetes and transgenic animal models) and endocrinology/ metabolism (cell signaling, cell-cell communication, and secretory pathway biology). Request is made for continued support of this highly successful program at the level of six pre-doctoral and two postdoctoral trainee positions. Nearly 5.9% of the U.S. population (or 16,000,000 people) have some form of diabetes mellitus. The need for basic and translational research in diabetes and endocrinology/metabolism has intensified. The past several years have witnessed an explosion of knowledge that links signaling at the level of the central nervous system to regulation of metabolism at the behavioral (feeding) and biochemical (regulation of hepatic glucose output) levels. Thus, the existing strengths of the Program in Endocrinology/metabolism and Neuroscience have synergized to provide a rich and integrated training environment at the cutting edge of research in molecular, cellular and clinical endocrinology research. Our research interactions and the joint training of pre-doctoral and postdoctoral students lend themselves to a highly integrated and cohesive program. Specifically, research training is provided in four major areas. These are: i) Regulation of Hormone Biosynthesis and Secretion (from gene expression to protein processing) (Carrasco, Fricker, Shields) ii) Hormone Receptor Expression, Structure, Function and Intracellular Targeting (Backer, Charron, Etgen, Rubin, Stanley, Zukin) iii) Signal Transduction Molecules, Effectors, and Pathways (Backer, Castillo, Etgen, Rubin, Shields, Stanley, Sze, Zukin) iv) Pathways Regulating Body Metabolism and Disturbances in Obesity and Diabetes (Brownlee, Charron, Chua, Etgen, Fricker, Hawkins, Mehler, Schwartz) Predoctoral fellows will carry out research projects under the supervision of one of the participating faculty in consultation with an advisory committee. Postdoctoral trainees (Ph.D.'s and/or M.D.'s) will engage in full-time research at an advanced level for 1 to 3 years in the laboratory of a faculty trainer. Through participation in works-in-progress seminars, research seminars, journal clubs and formal course work and highly collaborative research projects, trainees will intensively interact with other trainees and faculty mentors and develop the skills necessary for independent investigation. The program enables predoctoral and postdoctoral trainees to obtain multidisciplinary training in an area for which our institution has no other training grant support, namely diabetes and endocrinology/metabolism.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007513-25
Application #
8125068
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1985-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
25
Fiscal Year
2011
Total Cost
$202,050
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Neurosciences
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Scandiuzzi, Lisa; Ghosh, Kaya; Hofmeyer, Kimberly A et al. (2014) Tissue-expressed B7-H1 critically controls intestinal inflammation. Cell Rep 6:625-32
Abadi, Yael M; Jeon, Hyungjun; Ohaegbulam, Kim C et al. (2013) Host b7x promotes pulmonary metastasis of breast cancer. J Immunol 190:3806-14
Hofmeyer, Kimberly A; Scandiuzzi, Lisa; Ghosh, Kaya et al. (2012) Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection. J Immunol 189:3054-63
Lee, Jun Sik; Scandiuzzi, Lisa; Ray, Anjana et al. (2012) B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. J Immunol 189:4165-74
Israel, Davelene D; Sheffer-Babila, Sharone; de Luca, Carl et al. (2012) Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction. Endocrinology 153:2408-19
Hofmeyer, Kimberly A; Jeon, Hyungjun; Zang, Xingxing (2011) The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. J Biomed Biotechnol 2011:451694
Grove, Charlotte L; Szabo, Theresa M; McIntosh, J Michael et al. (2011) Fast synaptic transmission in the goldfish CNS mediated by multiple nicotinic receptors. J Physiol 589:575-95
Yang, Yupeng; Takeuchi, Koichi; Rodenas-Ruano, Alma et al. (2009) Developmental switch in requirement for PKA RIIbeta in NMDA-receptor-dependent synaptic plasticity at Schaffer collateral to CA1 pyramidal cell synapses. Neuropharmacology 56:56-65
Khan, Tayeba; Muise, Eric S; Iyengar, Puneeth et al. (2009) Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 29:1575-91
Khan, Tayeba; Hamilton, Mark P; Mundy, Dorothy I et al. (2009) Impact of simvastatin on adipose tissue: pleiotropic effects in vivo. Endocrinology 150:5262-72

Showing the most recent 10 out of 73 publications