This is a competitive renewal of NIH T32DK-07519, requesting funding for years 26-30 for 4 pre- and 5 post- doctoral positions, and also 3 short-term summer slot positions for minority students.
The aim i s to continue training the next generation of scientists in the clinically-relevant medical area of the regulation of hematopoietic cell production. Pre- and post-doctoral trainees will be trained 3-4 and 2-3 years, respectively.We assembled an outstanding group of 27 productive/interactive investigators from 7 departments of the medical school (Microbiology/Immunology, Biochemistry/Molecular Biology, Pharmacology/Toxicology, Medical/ Molecular Genetics, Medicine, Pediatrics, and General Surgery) who have trained pre- and/or post- doctoral students with multidisciplinary approaches using different cell types, and who have collectively co- published over 1000 papers with their students. Training emphasis is on hematopoietic stem (HSCs) and other blood cells, but includes studies with other cell types to enhance collaboration/training experiences. The PD studies HSCs and hematopoiesis, published >650 papers, is on numerous editorial boards/NIH/other review/advisory committees, is President of ASH, and has trained 66 pre/post docs. The Co-PD is well- recognized in the hematopoiesis area, has published >140 papers, trained >20 students/fellows, and served on numerous grant review committees. Our preceptors are funded, have extensive collaborations, co-publish with each other, have our labs within 5-10 minute walking distance, and are dedicated to training students in the area of this program. Training entails one-on-one interactions, formal committee meetings, lab meetings, special seminar series and journal club, didactic courses, ethical training and scientific meeting presentations. An Internal and External Advisory Committee monitors student/mentor and PD/Co-PD progress. Many of our past students are employed in academia. This training will enhance the future of hematopoietic cell regulation for basic understanding and translation for treatment of disease.

Public Health Relevance

Elucidating the basic biology of blood cells is crucial for understanding malignant and non-malignant hematopoietic disease initiation and progression, and means to successfully treat these disorders. This training will provide the next generation of scientists in this exciting, but still not fully-realized translational and clinical, discipline of blood cell production for the health benefit of our citizens.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007519-27
Application #
8281477
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Bishop, Terry Rogers
Project Start
1985-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
27
Fiscal Year
2012
Total Cost
$400,321
Indirect Cost
$31,477
Name
Indiana University-Purdue University at Indianapolis
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Ou, Xuan; Lee, Man Ryul; Huang, Xinxin et al. (2014) SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress. Stem Cells 32:1183-94
DiStasi, Matthew R; Unthank, Joseph L; Miller, Steven J (2014) Nox2 and p47(phox) modulate compensatory growth of primary collateral arteries. Am J Physiol Heart Circ Physiol 306:H1435-43
Walline, Crystal C; Deffit, Sarah N; Wang, Nan et al. (2014) Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy. Immunology 141:531-9
Speth, Jennifer M; Hoggatt, Jonathan; Singh, Pratibha et al. (2014) Pharmacologic increase in HIF1* enhances hematopoietic stem and progenitor homing and engraftment. Blood 123:203-7
Hoggatt, Jonathan; Mohammad, Khalid S; Singh, Pratibha et al. (2013) Differential stem- and progenitor-cell trafficking by prostaglandin E2. Nature 495:365-9
Berwick, Zachary C; Dick, Gregory M; O'Leary, Heather A et al. (2013) Contribution of electromechanical coupling between Kv and Ca v1.2 channels to coronary dysfunction in obesity. Basic Res Cardiol 108:370
Broxmeyer, Hal E; Mor-Vaknin, Nirit; Kappes, Ferdinand et al. (2013) Concise review: role of DEK in stem/progenitor cell biology. Stem Cells 31:1447-53
Gourapura, Renukaradhya J; Khan, Masood A; Gallo, Richard M et al. (2013) Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression. PLoS One 8:e72867
Hoggatt, Jonathan; Mohammad, Khalid S; Singh, Pratibha et al. (2013) Prostaglandin E2 enhances long-term repopulation but does not permanently alter inherent stem cell competitiveness. Blood 122:2997-3000
Ou, Xuan; O'Leary, Heather A; Broxmeyer, Hal E (2013) Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types. Blood 122:161-9

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