The Brigham and Women's Hospital Nephrology training program, which has been funded for 27 consecutive years, seeks to continue to provide scientifically rigorous, multidisciplinary research training in academic nephrology to postdoctoral fellows who have previously earned M.D., and/or Ph.D. degrees. Individuals accepted into the training program dedicate three or more years to research activities in bench science, clinical nephrology research studies, and/or translational investigation. The program is enriched with regularly scheduled lectures and seminars as well as local, regional, and national courses. Participants enroll in formal postgraduate course work at Harvard University or MIT. The most important component of the proposed program is the intensive research training for several years under the mentorship of experienced and committed investigators who have extensive track records of securing independent funding from the NIH and other sources. Emphasis is placed on integration of basic and applied nephrology. Basic research opportunities in physiology and clinically relevant areas include (but are not limited to) physiological, cellular ad molecular basis of solute and fluid exchange, physiology and pharmacology of vasoactive hormones, human and mouse genetics, bioengineering, nanotechnology, tissue engineering, regenerative biology, and immunological mechanisms in kidney diseases. In addition, there is a large program in clinical and translational transplantation immunology. Clinical research opportunities include epidemiological and patient-oriented investigations in chronic kidney disease, hypertension, mineral metabolism, the cardiorenal syndromes, dialysis, and genetics as well as novel urinary biomarkers in acute and chronic kidney disease, and randomized clinical trials. Our 39 research mentors are outstanding faculty at Harvard and/or MIT, representing many disciplines and departments. Since our last T32 renewal, the program has made notable progress in formalizing the evaluation of trainees'development as well as providing increased opportunities for research presentations and feedback. A review of our Brigham Renal Division research trainees who have received T32 support as well as those with other research funds over the past 10 years revealed remarkable publication productivity and success in obtaining grant funding with the majority (76%) of trainees supported by this grant continuing in academic nephrology or in leadership roles in clinical research. We look forward to continuing our tradition of excellence in training leaders in nephrology while continuing to critically assess and improve the fellowship experience by providing outstanding research and mentoring opportunities to the next generation of nephrology investigators.

Public Health Relevance

The primary mission of the Brigham and Women's Hospital nephrology research training program is to nurture the development of the future leaders in academic nephrology during their early, formative stages. This is accomplished by providing our fellowship trainees with rigorous post-doctoral experience and unparalleled resources for cutting-edge basic science, clinical, and translational investigation over three years of mentored research training. Moreover, the program leadership and faculty mentors promote the growth of our fellows through thoughtful mentorship, high quality scientific seminars and programs, frequent opportunities for research trainee presentation and constructive feedback, and an overall focus on facilitation of research progress and career development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007527-29
Application #
8495315
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
1985-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
29
Fiscal Year
2013
Total Cost
$464,231
Indirect Cost
$33,133
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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Santos, Ruda de Luna Almeida; Bai, Lin; Singh, Pradeep K et al. (2017) Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. Nat Commun 8:1692
Singh, Karandeep; Waikar, Sushrut S; Samal, Lipika (2017) Evaluating the feasibility of the KDIGO CKD referral recommendations. BMC Nephrol 18:223
Win, Thet Su; Murakami, Naoka; Borges, Thiago J et al. (2017) Longitudinal immunological characterization of the first presensitized recipient of a face transplant. JCI Insight 2:
Kishi, Seiji; Minato, Masanori; Saijo, Atsuro et al. (2017) A Case of IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma. Intern Med :
Khattak, Aisha; Mandel, Ernest I; Reynolds, Matthew R et al. (2017) Percutaneous Coronary Intervention Versus Optimal Medical Therapy for Stable Angina in Advanced CKD: A Decision Analysis. Am J Kidney Dis 69:350-357
Tögel, Florian; Valerius, M Todd; Freedman, Benjamin S et al. (2017) Repair after nephron ablation reveals limitations of neonatal neonephrogenesis. JCI Insight 2:e88848
Mavrakanas, Thomas A; Khattak, Aisha; Singh, Karandeep et al. (2017) Epidemiology and Natural History of the Cardiorenal Syndromes in a Cohort with Echocardiography. Clin J Am Soc Nephrol 12:1624-1633
Murakami, Naoka; Motwani, Shveta; Riella, Leonardo V (2017) Renal complications of immune checkpoint blockade. Curr Probl Cancer 41:100-110
Leaf, David E; Jacob, Kirolos A; Srivastava, Anand et al. (2017) Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness. J Am Soc Nephrol 28:1877-1885

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