The primary goal of this ongoing interdisciplinary training program, currently in the 25th year, is to bring together pre-clinical scientists and translational investigative researchers to catalyze the transformation of postdoctoral students from both basic science and clinical disciplines into independent academic faculty committed to kidney-relevant research. The training program builds on new initiatives in renal pathophysiology, cell and molecular biology, vascular biology, basic immunology, genetics, transplantation, acute and chronic kidney disease and in clinical and translational research. The UAB Clinical and Translational Science Award and the Office for Postdoctoral Education provide essential facilities that embrace trainee education as well as mentor training, also a major goal of this program. The Program accepts PhD and MD scientists from a large applicant pool that now includes physicians in the American Board of Internal Medicine Research pathway, which recruits highly meritorious candidates to pursue a career in academic medicine. Twenty-two (50%) of our 44 trainees are in academia, 20% are still pursuing post-graduate training and 7% have pursued non-academic positions, although still in science-based careers. Trainees have been successful in obtaining 20 highly competitive extramural grants, including 13 career development awards. During the past 10 years, 18 trainees have published 68 peer- reviewed publications including papers in high-impact journals. The program has benefitted from a multidisciplinary collaborative faculty from 9 Departments (Medicine, Cell Developmental and Integrative Biology, Epidemiology, Microbiology, Emergency Medicine, Genetics, Pathology, Pediatrics, Surgery) and robust institutional infrastructure and support. The strong commitment of the 34 preceptors, organized in four thematic areas - renal physiology and pathophysiology, epithelial biology, vascular biology related to kidney disease and clinical and translational research - who are actively involved in the training of young scientists in the use of basic and applied approaches are also strengths of this training grant. The collaborative environment of our institution, embodied in the University-Wide Interdisciplinary Research Centers Program, the Nephrology Research and Training Center, and the NIDDK-funded O'Brien Center, provides an ideal setting for the implementation of interdisciplinary kidney-related research and training. Based on the accomplishments during this cycle, continued support of four postdoctoral trainees is being requested in this competing renewal application.

Public Health Relevance

The Interdisciplinary Training in Kidney-Related Diseases Training Program is focused on training basic and translational investigators to be productive, highly motivated investigators in the future. Our trainees are selected from a competitive pool of independent postdoctoral fellows who show interest in furthering the fundamental understanding of diseases of the kidney.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007545-26S1
Application #
8854933
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
1987-07-01
Project End
2019-03-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
26
Fiscal Year
2014
Total Cost
$65,316
Indirect Cost
$4,638
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Hanks, Lynae J; Casazza, Krista; Ashraf, Ambika P et al. (2015) Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females. Clin Endocrinol (Oxf) 82:550-6
Clement, Lionel C; Mace, Camille; Avila-Casado, Carmen et al. (2014) Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome. Nat Med 20:37-46
Hanks, Lynae J; Casazza, Krista; Ashraf, Ambika P et al. (2013) Vitamin D and calcium-sensing receptor polymorphisms differentially associate with resting energy expenditure in peripubertal children. J Bone Miner Metab 31:695-702
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Mitchell, Tanecia; Johnson, Michelle S; Ouyang, Xiaosen et al. (2013) Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived *-cells. Am J Physiol Endocrinol Metab 305:E585-99
Mitchell, Tanecia; Chacko, Balu; Ballinger, Scott W et al. (2013) Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics. Biochem Soc Trans 41:127-33
Mitchell, Tanecia; Darley-Usmar, Victor (2012) Metabolic syndrome and mitochondrial dysfunction: insights from preclinical studies with a mitochondrially targeted antioxidant. Free Radic Biol Med 52:838-40
Williams, Corey L; Li, Chunmei; Kida, Katarzyna et al. (2011) MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis. J Cell Biol 192:1023-41
Masyukova, Svetlana V; Winkelbauer, Marlene E; Williams, Corey L et al. (2011) Assessing the pathogenic potential of human Nephronophthisis disease-associated NPHP-4 missense mutations in C. elegans. Hum Mol Genet 20:2942-54
Williams, Corey L; Masyukova, Svetlana V; Yoder, Bradley K (2010) Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4. J Am Soc Nephrol 21:782-93

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