This continuation proposal requests support for the Molecular Endocrinology Training Program (METP) at Vanderbilt. Twenty nine faculty members from five basic science departments-constitute the preceptors of the METP. Of this group 25 are established faculty with stable, well-funded programs and training experience and 4 are new investigators. The preceptor group constitutes an unusually diverse and talented group of individuals whose work covers the spectrum of molecular endocrinology. These preceptors conduct research in the general areas of: 1) signal transduction 2) the hormonal regulation of gene expression, 3) metabolic regulation and 4) Stem cells, ( cell development and function. The request for maintaining the current level of 8 predoctoral and 4 postdoctoral trainees is justified on the basis of the number, size and quality of the research programs directed by the preceptors. All METP trainees are appointed upon the advice of an Advisory Committee after being nominated by a preceptor. Postdoctoral trainees have a Ph.D. degree. Rigorous in-depth research training is the focus of both the pre- and postdoctoral training programs. However, the METP also ensures that all trainees receive a broad didactic education. In addition, all METP trainees attend the NIDDK-funded Vanderbilt Diabetes Research and Training Center seminar series and meet with the visiting scientists. New additions to the program include (i) a didactic course focusing on the molecular endocrinology of obesity and diabetes, (ii) an Annual METP Day and weekly data clubs to foster interactions between trainees and preceptors, (iii) a post-doctoral trainee mentoring program, and (iv) training in both grant writing as well as laboratory &project management. The Program also provides formal training in the proper use of radioisotopes, in appropriate procedures of dealing with toxic and dangerous materials, and in the responsible conduct in research. METP trainees also have access to a formal career-counseling program. The METP has been successful in attracting and supporting the training of individuals from diverse backgrounds. Relevance: The field of Molecular Endocrinology is of central relevance to multiple human diseases, most notably obesity and diabetes. Continued progress towards understanding and curing these and many other diseases requires the training of the next generation of scientists, which is the goal of this program.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Schools of Medicine
United States
Zip Code
Boortz, Kayla A; Syring, Kristen E; Pound, Lynley D et al. (2016) Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression. PLoS One 11:e0162439
Henley, Kathryn D; Stanescu, Diana E; Kropp, Peter A et al. (2016) Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function. Cell Rep 15:2637-50
Conrad, Elizabeth; Dai, Chunhua; Spaeth, Jason et al. (2016) The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells. Am J Physiol Endocrinol Metab 310:E91-E102
Williams, Ian M; Otero, Yolanda F; Bracy, Deanna P et al. (2016) Chronic Angiotensin-(1-7) Improves Insulin Sensitivity in High-Fat Fed Mice Independent of Blood Pressure. Hypertension 67:983-91
Boortz, Kayla A; Syring, Kristen E; Dai, Chunhua et al. (2016) G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology 157:3002-8
Dai, Chunhua; Kayton, Nora S; Shostak, Alena et al. (2016) Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. J Clin Invest 126:1857-70
Anderson, Erica J P; Çakir, Isin; Carrington, Sheridan J et al. (2016) 60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH. J Mol Endocrinol 56:T157-74
Boortz, Kayla A; Syring, Kristen E; Lee, Rebecca A et al. (2016) G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance. Endocrinology 157:4133-4145
Cho, Sung Hoon; Raybuck, Ariel L; Stengel, Kristy et al. (2016) Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Nature 537:234-238
Syring, Kristen E; Boortz, Kayla A; Oeser, James K et al. (2016) Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion. Endocrinology 157:4534-4541

Showing the most recent 10 out of 181 publications