This proposal requests continued support for the Molecular Endocrinology Training Program (METP) at Vanderbilt University. Progress towards understanding and curing obesity, diabetes and many other diseases requires the training of the next generation of scientists with expertise in molecular endocrinology, the goal of this program. The METP comprises 30 faculty members in 6 basic science departments. Of this group 27 are established faculty with stable, well-funded programs and substantial training experience and 3 are new investigators;5 of these preceptors are female, 1 is a minority and 1 is disabled. This preceptor group constitutes a unusually diverse and talented group of individuals whose work covers the spectrum of molecular endocrinology. These preceptors conduct research in the general areas of: 1) signal transduction 2) the hormonal regulation of gene expression, 3) metabolic regulation and 4) beta-cell development and function. The request for a steady state level of 8 predoctoral and 4 postdoctoral trainees is justified on the basis of the number, size and quality of the research programs directed by the preceptors and the Institutional commitment to continue the same level of trainee recruitment despite the tough economic climate. All METP trainees are appointed upon the advice of an Admissions Committee after being nominated by a preceptor. Postdoctoral trainees have a Ph.D. degree. Rigorous in depth research training is the focus of both the pre and postdoctoral training programs. However, the METP also ensures that all trainees receive a broad didactic education. Predoctoral training in the METP follows that received in the Interdisciplinary Graduate Program (IGP). The IGP recruits almost all predoctoral trainees in the biomedical sciences at Vanderbilt, provides a first year core curriculum, safety training and formal evaluation and career counseling programs. This centralized recruitment has considerably increased the number and quality of predoctoral students that enter Vanderbilt. After four laboratory rotations predoctoral students choose a preceptor for their thesis project and compete for METP support. The IGP and METP have been very successful in promoting diversity and both provide ongoing training in the Responsible Conduct of Research. All METP trainees attend an annual METP Day retreat and the Vanderbilt Diabetes Center (VDC) seminar series where they meet with visiting scientists. In conjunction with the Juvenile Diabetes Research Foundation the METP has recently initiated a novel strategy to increase the recruitment of disabled individuals, specifically undergraduates with type 1 diabetes, through the creation of a VDC funded Summer Diabetes Research Program. The METP has already successfully trained 153 scientists of whom 54 have already gone onto assume academic/pharmaceutical positions with another 34 trainees still in training.
The field of molecular endocrinology is of central relevance to multiple common human diseases, most notably obesity and diabetes. Continued progress towards understanding and curing these and many other diseases requires the training of the next generation of scientists with expertise in molecular endocrinology, which is the goal of the Molecular Endocrinology Training Program.
|Johnson, Amanda N; Weil, P Anthony (2017) Identification of a transcriptional activation domain in yeast repressor activator protein 1 (Rap1) using an altered DNA-binding specificity variant. J Biol Chem 292:5705-5723|
|Dean, E Danielle; Li, Mingyu; Prasad, Nripesh et al. (2017) Interrupted Glucagon Signaling Reveals Hepatic ? Cell Axis and Role for L-Glutamine in ? Cell Proliferation. Cell Metab 25:1362-1373.e5|
|Perreault, Andrea A; Benton, Mary Lauren; Koury, Mark J et al. (2017) Epo reprograms the epigenome of erythroid cells. Exp Hematol 51:47-62|
|Boortz, Kayla A; Syring, Kristen E; Pound, Lynley D et al. (2017) Effects of G6pc2 deletion on body weight and cholesterol in mice. J Mol Endocrinol 58:127-139|
|Yang, Yu-Ping; Magnuson, Mark A; Stein, Roland et al. (2017) The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal ?-cell maturation. Development 144:248-257|
|Vierra, Nicholas C; Dadi, Prasanna K; Milian, Sarah C et al. (2017) TALK-1 channels control ? cell endoplasmic reticulum Ca2+ homeostasis. Sci Signal 10:|
|Reissaus, Christopher A; Piston, David W (2017) Reestablishment of Glucose Inhibition of Glucagon Secretion in Small Pseudoislets. Diabetes 66:960-969|
|Dean, E Danielle; Unger, Roger H; Holland, William L (2017) Glucagon antagonism in islet cell proliferation. Proc Natl Acad Sci U S A 114:3006-3008|
|Crowder, Mark K; Seacrist, Corey D; Blind, Raymond D (2017) Phospholipid regulation of the nuclear receptor superfamily. Adv Biol Regul 63:6-14|
|Cho, Sung Hoon; Raybuck, Ariel L; Stengel, Kristy et al. (2016) Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Nature 537:234-238|
Showing the most recent 10 out of 205 publications