The increasing incidence of kidney disease in the U.S. and worldwide represents a major challenge to our health systems. There is a growing urgency to train physician scientists and Ph.D. scientists who can increase our understanding of disease pathogenesis and develop, implement and assess new therapeutic modalities to combat renal disease. The goal of the Vanderbilt Nephrology Training Program is to provide promising M.D. and/or Ph.D. postdoctoral fellows with the knowledge and the tools to become the leaders in both basic and translational research efforts to generate new understanding in the pathogenesis of kidney diseases and to develop and implement new treatments and cures for our patients with kidney disease. The faculty who participate in the Vanderbilt Nephrology Training Program represent a group of talented and accomplished researchers with a broad range of scientific expertise and research interests. This group consists of 25 investigators whose primary appointment is in either Adult or Pediatric Nephrology and 27 other clinical and basic scientists who have ongoing interests in kidney disease or associated scientific questions. The training faculty are based in 10 departments: Medicine, Pediatrics, Pathology, Cancer Biology, Surgery, Cell Biology, Biochemistry, Anesthesia and Biostatistics. Research interests of the primary faculty include mechanisms of chronic glomerular and tubulointerstitial injury, acute kidney injury, cell-matrix and cell-cell interactions, renal development, epithelial cell biology, eicosanoid biology, epidemiology of progressive kidney disease, development of clinical biomarkers, health services research and clinical trials. Our training program is structured to provide physician/scientist (M.D. or M.D/Ph.D.) and selected basic scientist (Ph.D) trainees with a focused and productive research experience that will serve as the foundation for an independent investigative career directed toward understanding and treatment of renal disease. Research opportunities for training in kidney disease have greatly expanded at Vanderbilt both within and outside of the Nephrology Division since the previous submission of this training program. In the present application, we are therefore requesting an increase in support from three to five postdoctoral trainees per year.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007569-25S1
Application #
8898670
Study Section
Special Emphasis Panel (ZDK1-GRB-G (J2))
Program Officer
Rys-Sikora, Krystyna E
Project Start
1993-09-30
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
25
Fiscal Year
2014
Total Cost
$58,625
Indirect Cost
$4,343
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
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Hung, Adriana M; Siew, Edward D; Wilson, Otis D et al. (2018) Risk of Hypoglycemia Following Hospital Discharge in Patients With Diabetes and Acute Kidney Injury. Diabetes Care 41:503-512
Wild, Marcus G; Wallston, Kenneth A; Green, Jamie A et al. (2017) The Perceived Medical Condition Self-Management Scale can be applied to patients with chronic kidney disease. Kidney Int 92:972-978
Kensinger, Clark; Hernandez, Antonio; Bian, Aihua et al. (2017) Longitudinal assessment of cardiac morphology and function following kidney transplantation. Clin Transplant 31:
Kensinger, Clark D; Feurer, Irene D; Karp, Seth J (2017) An Outcome-Based Approach to Assign MELD Exception Points for Patients With Hepatocellular Cancer. Transplantation 101:2056-2061
Overstreet, Jessica M; Wang, Yinqiu; Wang, Xin et al. (2017) Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis. FASEB J 31:4407-4421
Beach, Lauren B; Wild, Marcus; Ramachandran, Gowri et al. (2016) Protocol of a randomized controlled trial of an erythropoietin stimulating agent decision aid for anemia treatment in kidney disease. BMC Nephrol 17:86
Siew, Edward D; Parr, Sharidan K; Abdel-Kader, Khaled et al. (2016) Predictors of Recurrent AKI. J Am Soc Nephrol 27:1190-200
Kensinger, Clark; Bian, Aihua; Fairchild, Meagan et al. (2016) Long term evolution of endothelial function during kidney transplantation. BMC Nephrol 17:160

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