This is a renewal application for a GI Training Grant (TG) at the Johns Hopkins University School of Medicine for the training of (A) postdoctoral fellows (MD, MD/PhD or PhD) for long-term investigative careers in basic and translational investigation in Gastroenterology. This program has strong basic science investigators in the GI Division;a formal 4 year program for training translational/clinical investigators done in collaboration with the Hopkins School of Public Health resulting in a PhD or MPH in clinical research;close interactions with Hopkins Basic Scientists;a closely knit group of scientists interested in epithelial cell and molecular biology, inflammation, fibrosis and GI cancer, neurogastroenterology, and IBD;an NIDDK Conte GI Core Center Grant;PPGs on trafficking in epithelial cells, intestinal heavy metal transport and pancreatic development and cancer;and a U18 on enteroids as models of GI disease. The TG faculty (25) have primary appointments in the GI Division (16);Departments of Cell Biology (1);Physiology (3);other Dept of Medicine (2);Pathology (1);Oncology (2);Surgery (1);Pediatrics (1);Genetics (1). The Hopkins GI Division has several areas of expertise for research training of fellows-BASIC: studies of epithelial transport, polarization, differentiation, and trafficking of membrane proteins, actions of bacterial enterotoxins, inflammation causing fibrosis and cancer, neurogastroenterology, IBD, genes activated in pancreatic cancer and epigenetics and biomarker discovery of GI cancer. TRANSLATIONAL/CLINICAL: IBD and GI cancer biomarker discovery, confocal endoscopy in GI disease, and diversity and GI disease. A total of 5 Postdoctoral TG slots are requested per year to be used for 3-4 MD or MD/PhD and/or 1 or 2 PhD fellows. The program is for (a) 2-3 years in the laboratory or 3 years of clinical research training leading to a PhD or MPH, in addition to a clinical year not supported by the TG, and (B) a predoctoral program (~3 years) to train future basic science faculty who do basic science GI related research. All Fellows are assigned a Fellowship Committee to monitor their progress. Fellows who are thought to be successful in being prepared for investigative careers are helped to apply for K awards and appointed as junior faculty to continue career development.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007632-26
Application #
8646139
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
Project End
Budget Start
Budget End
Support Year
26
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Hendrix, Craig W; Andrade, Adriana; Bumpus, Namandjé N et al. (2016) Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066). AIDS Res Hum Retroviruses 32:32-43
In, Julie; Foulke-Abel, Jennifer; Zachos, Nicholas C et al. (2016) Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. Cell Mol Gastroenterol Hepatol 2:48-62.e3
Zachos, Nicholas C; Kovbasnjuk, Olga; Foulke-Abel, Jennifer et al. (2016) Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. J Biol Chem 291:3759-66
Foulke-Abel, Jennifer; In, Julie; Yin, Jianyi et al. (2016) Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology 150:638-649.e8
Guerrerio, Anthony L; Frischmeyer-Guerrerio, Pamela A; Huang, Chengrui et al. (2016) Increased Prevalence of Inflammatory Bowel Disease in Patients with Mutations in Genes Encoding the Receptor Subunits for TGFβ. Inflamm Bowel Dis 22:2058-62
In, Julie G; Foulke-Abel, Jennifer; Estes, Mary K et al. (2016) Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nat Rev Gastroenterol Hepatol 13:633-642
Mann, Elizabeth R; Bernardo, David; English, Nicholas R et al. (2016) Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum. Gut 65:256-70
Bernardo, David; Durant, Lydia; Mann, Elizabeth R et al. (2016) Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal Colon. Cell Mol Gastroenterol Hepatol 2:22-39.e5
Janecke, Andreas R; Heinz-Erian, Peter; Yin, Jianyi et al. (2015) Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea. Hum Mol Genet 24:6614-23
Chen, L A; Van Meerbeke, S; Albesiano, E et al. (2015) Fecal detection of enterotoxigenic Bacteroides fragilis. Eur J Clin Microbiol Infect Dis 34:1871-7

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