This is a competing renewal application to continue training postdoctoral fellows in nephrology research. Our goal is to prepare fellows for a career in Academic Nephrology by training them to use modern techniques of cellular and molecular biology or epidemiology and clinical investigation while investigating a specific project. We will continue to rely on an interdisciplinary approach that involves preceptors from the Renal Division and from the Departments of Physiology and Surgery, and from Cardiology and Gastroenterology. Our proposed program is based on ongoing scientific interactions between faculty of the Renal Division and the Basic Sciences. The Director of the Training Grant will be Dr. Jeff M. Sands and the Co-Directors will be Dr. Douglas C. Eaton and Dr. S. Russ Price. Each of the 15 preceptors has an outstanding training record and research funding from the NIH and/or VA. Proposed research projects can be grouped into four major areas based on the questions being addressed: physiology;cellular and molecular biology;transplant immunology;and epidemiology/clinical investigation. We believe involving trainees directly in a specific project plus formal and informal courses in statistics and in cellular and molecular biology, and interaction with clinical investigators will provide them with a first-rate opportunity to develop a career in Academic Medicine. Two categories of trainees will be chosen: 1) M.D.s or M.D./Ph.D.s from the Adult and Pediatric Nephrology Fellowship programs;and 2) Ph.D. candidates. Over the past 10 years, there have been 16 trainees supported by this grant: 8 continue to pursue academic careers in basic or clinical research with full-time medical school faculty positions, 1 is in Internal Medicine residency training, 5 are in nephrology practice, and 2 will be entering their second year of research training during the last year of the current funding period. Thus, 8 of the 13 trainees (62%) who completed all of their training during 2000-2010 entered academic medicine and are currently full-time faculty members at a medical school. The 16 trainees included 7 women and 4 members of an under-represented minority group. Ten of the 14 trainees who have completed training have published peer-reviewed papers;the other 4 trainees have published abstracts and presented their data at National scientific meetings. We have filled every available position every year since the start of this program in 1990. We seek funding to continue this successful training program.

Public Health Relevance

Our goal is to train the next generation of renal investigators in order to improve our understanding of renal disease in patients. Our research program will teach young investigators to apply modern techniques to answer questions related to the consequences of kidney disease. This offers an excellent opportunity to identify and treat these conditions. We have designed a Training Program that emphasizes existing interactions between Renal Division faculty and investigators in other Divisions and Departments at Emory.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007656-23
Application #
8509672
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
1990-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
23
Fiscal Year
2013
Total Cost
$148,475
Indirect Cost
$12,806
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Mistry, Abinash C; Wynne, Brandi M; Yu, Ling et al. (2016) The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate. Biochem J 473:3237-52
Wall, Susan M; Lazo-Fernandez, Yoskaly (2015) The role of pendrin in renal physiology. Annu Rev Physiol 77:363-78
Lazo-Fernandez, Yoskaly; Aguilera, Greti; Pham, Truyen D et al. (2015) Pendrin localizes to the adrenal medulla and modulates catecholamine release. Am J Physiol Endocrinol Metab 309:E534-45
Nanami, Masayoshi; Lazo-Fernandez, Yoskaly; Pech, Vladimir et al. (2015) ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. I. Stilbene-sensitive Cl- secretion. Am J Physiol Renal Physiol 309:F251-8
Blount, Mitsi A; Cipriani, Penelope; Redd, Sara K et al. (2015) Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct. Am J Physiol Cell Physiol 309:C608-15
Nanami, Masayoshi; Pech, Vladimir; Lazo-Fernandez, Yoskaly et al. (2015) ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. II. Bafilomycin-sensitive H+ secretion. Am J Physiol Renal Physiol 309:F259-68
Pech, Vladimir; Wall, Susan M; Nanami, Masayoshi et al. (2015) Pendrin gene ablation alters ENaC subcellular distribution and open probability. Am J Physiol Renal Physiol 309:F154-63
Grimm, P Richard; Lazo-Fernandez, Yoskaly; Delpire, Eric et al. (2015) Integrated compensatory network is activated in the absence of NCC phosphorylation. J Clin Invest 125:2136-50
Thai, Tiffany L; Yu, Ling; Eaton, Douglas C et al. (2014) Basolateral P2Xâ‚„channels stimulate ENaC activity in Xenopus cortical collecting duct A6 cells. Am J Physiol Renal Physiol 307:F806-13
Williams, Clintoria R; Gooch, Jennifer L (2014) Calcineurin A* regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose. J Biol Chem 289:4896-905

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