There is a tremendous need in the United States to increase the number of academic investigators who perform research that will directly impact the care of patients with digestive diseases. For many of these disorders, the fundamental pathobiology is not well understood and effective disease-modifying treatments are not available. This proposal describes the continuation of the combined adult-pediatric Training in Gastroenterology Program that provides multidisciplinary training for postdoctoral scientists in basic research or in clinical/translational research, and which is committed to equipping young investigators with the skill set necessary to overcome obstacles preventing them from developing into successful academic leaders. The Divisions of Adult and Pediatric Gastroenterology, Hepatology and Nutrition and the Vanderbilt Digestive Diseases Research Center (VDDRC) have a long and successful history of developing well-trained researchers who have the vision and skills with which to embark on successful careers in academic Gastroenterology. Dr. Richard Peek (Director of the VDDRC) serves as Program Director. He will be assisted by two Co-Associate Directors;Dr. Sari Acra, Director of the Division of Pediatric Gastroenterology and Dr. Keith Wilson, Director of the Adult Gastroenterology fellowship program as well as Internal and External Advisory Committees composed of senior faculty deeply invested in training young investigators. The program is designed to support postdoctoral fellows (M.D., M.D./Ph.D., Ph.D.) who show exceptional aptitude for successfully pursuing an academic career. Postdoctoral trainees will be selected from the pool of fellows accepted into the Adult and Pediatric GI training programs, physician-scientist applicants from various other clinical training programs at Vanderbilt and applicants that apply to preceptor laboratories. A customized mentoring team is constructed for each trainee consisting of a Mentor with nationally recognized expertise and a Research Advisory Committee to provide additional guidance, mentoring and feedback. The trainee's experience is enriched by interactions with other investigators and trainees in the VDDRC, an extensive program of seminars and conferences, and coursework tailored to meet individual needs. The unique environment that supports digestive disease research at Vanderbilt, consisting of rich collaborative interactions between basic and clinical researchers, a wide range of supporting VDDRC and non-VDDRC Cores and Centers, and exposure to state-of-the-art clinical care, provides an outstanding opportunity to train successful scientists whose discoveries regarding fundamental aspects of digestive diseases can be rapidly translated into improved patient care.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007673-21
Application #
8663392
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Nicholson, Maribeth R; Thomsen, Isaac P; Slaughter, James C et al. (2015) Novel risk factors for recurrent Clostridium difficile infection in children. J Pediatr Gastroenterol Nutr 60:18-22
Weis, Victoria G; Petersen, Christine P; Mills, Jason C et al. (2014) Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach. Am J Physiol Gastrointest Liver Physiol 307:G777-92
Falaiye, Tolulope O; Mitchell, Keisha R; Lu, Zengqi et al. (2014) Outcomes following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant IBD. J Pediatr Gastroenterol Nutr 58:213-9
Arboleda, Richard N; Schneider, Barbara G; Bravo, Luis E et al. (2013) Use of the noninvasive entero-test in the detection of Helicobacter pylori in children in an endemic area in Colombia. J Pediatr Gastroenterol Nutr 57:192-6
Wattacheril, Julia; Seeley, Erin H; Angel, Peggi et al. (2013) Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis. PLoS One 8:e57165
Coburn, Lori A; Gong, Xue; Singh, Kshipra et al. (2012) L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS One 7:e33546
Rippel, Sara W; Acra, Sari; Correa, Hernan et al. (2012) Pediatric patients with dyspepsia have chronic symptoms, anxiety, and lower quality of life as adolescents and adults. Gastroenterology 142:754-61
Barry, Daniel P; Asim, Mohammad; Scull, Brooks P et al. (2011) Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection. PLoS One 6:e29046
Dengler-Crish, Christine M; Horst, Sara N; Walker, Lynn S (2011) Somatic complaints in childhood functional abdominal pain are associated with functional gastrointestinal disorders in adolescence and adulthood. J Pediatr Gastroenterol Nutr 52:162-5
Thomsen, Kelly F; Laposata, Michael; Njoroge, Sarah W et al. (2011) Increased elongase 6 and ?9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis. Lipids 46:669-77

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