There is a tremendous need in the United States to increase the number of academic investigators who perform research that will directly impact the care of patients with digestive diseases. For many of these disorders, the fundamental pathobiology is not well understood and effective disease-modifying treatments are not available. This proposal describes the continuation of the combined adult-pediatric Training in Gastroenterology Program that provides multidisciplinary training for postdoctoral scientists in basic research or in clinical/translational research, and which is committed to equipping young investigators with the skill set necessary to overcome obstacles preventing them from developing into successful academic leaders. The Divisions of Adult and Pediatric Gastroenterology, Hepatology and Nutrition and the Vanderbilt Digestive Diseases Research Center (VDDRC) have a long and successful history of developing well-trained researchers who have the vision and skills with which to embark on successful careers in academic Gastroenterology. Dr. Richard Peek (Director of the VDDRC) serves as Program Director. He will be assisted by two Co-Associate Directors;Dr. Sari Acra, Director of the Division of Pediatric Gastroenterology and Dr. Keith Wilson, Director of the Adult Gastroenterology fellowship program as well as Internal and External Advisory Committees composed of senior faculty deeply invested in training young investigators. The program is designed to support postdoctoral fellows (M.D., M.D./Ph.D., Ph.D.) who show exceptional aptitude for successfully pursuing an academic career. Postdoctoral trainees will be selected from the pool of fellows accepted into the Adult and Pediatric GI training programs, physician-scientist applicants from various other clinical training programs at Vanderbilt and applicants that apply to preceptor laboratories. A customized mentoring team is constructed for each trainee consisting of a Mentor with nationally recognized expertise and a Research Advisory Committee to provide additional guidance, mentoring and feedback. The trainee's experience is enriched by interactions with other investigators and trainees in the VDDRC, an extensive program of seminars and conferences, and coursework tailored to meet individual needs. The unique environment that supports digestive disease research at Vanderbilt, consisting of rich collaborative interactions between basic and clinical researchers, a wide range of supporting VDDRC and non-VDDRC Cores and Centers, and exposure to state-of-the-art clinical care, provides an outstanding opportunity to train successful scientists whose discoveries regarding fundamental aspects of digestive diseases can be rapidly translated into improved patient care.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Weis, Victoria G; Petersen, Christine P; Weis, Jared A et al. (2017) Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol 312:G67-G76
Juttukonda, Lillian J; Berends, Evelien T M; Zackular, Joseph P et al. (2017) Dietary Manganese Promotes Staphylococcal Infection of the Heart. Cell Host Microbe 22:531-542.e8
Vaezi, Michael F; Choksi, Yash (2017) Mucosal Impedance: A New Way To Diagnose Reflux Disease and How It Could Change Your Practice. Am J Gastroenterol 112:4-7
Nicholson, Maribeth R; Crews, Jonathan D; Starke, Jeffrey R et al. (2017) Recurrent Clostridium difficile Infection in Children: Patient Risk Factors and Markers of Intestinal Inflammation. Pediatr Infect Dis J 36:379-383
McDonough, Elizabeth M; Barrett, Caitlyn W; Parang, Bobak et al. (2017) MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight 2:
Wattacheril, Julia; Rose, Kristie L; Hill, Salisha et al. (2017) Non-alcoholic fatty liver disease phosphoproteomics: A functional piece of the precision puzzle. Hepatol Res 47:1469-1483
Tessmer, Maxx H; Anderson, David M; Buchaklian, Adam et al. (2017) Cooperative Substrate-Cofactor Interactions and Membrane Localization of the Bacterial Phospholipase A2 (PLA2) Enzyme, ExoU. J Biol Chem 292:3411-3419
Kohl, Kevin D; Dearing, M Denise; Bordenstein, Seth R (2017) Microbial communities exhibit host species distinguishability and phylosymbiosis along the length of the gastrointestinal tract. Mol Ecol :
Mera, Robertino M; Bravo, Luis E; Camargo, M Constanza et al. (2017) Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut :
Coburn, Lori A; Horst, Sara N; Allaman, Margaret M et al. (2016) L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis. Inflamm Bowel Dis 22:1847-58

Showing the most recent 10 out of 73 publications