This application proposes continued support of a successful research-based training program in Endocrinology and Metabolism at Oregon Health &Science University. The main goal of this program, now in its 14th year, is to prepare qualified trainees for successful scientific careers as independent investigators by providing intensive training in hypothesis-driven, basic and disease-oriented research in a stimulating and collegial academic environment. Potential candidates will hold an MD, MD/PhD, or PhD degree. Successful MD candidates will have completed residency training as well as a first, clinical year of endocrine fellowship training prior to enrolling in this program. This requirement allows both MD and PhD trainees to devote at least 80% of their time to first hand experience and training in hypothesis-driven endocrine research under the supervision of an established successful investigator. Research activities will be supplemented by weekly journal clubs, research-in-progress meetings, endocrine research grand rounds, and by formal graduate level course work tailored to the individual scientific needs of each trainee. The special strengths of this program include: 1) The diverse skills and research interests of the faculty in a wide variety of areas including growth factors, thyroid, pituitary, adrenal, signal transduction, molecular genetics, diabetes, obesity, bone and mineral metabolism, lipid disorders, metabolic derangements and reproductive endocrinology. 2) The substantial laboratory resources of the faculty and recently expanded clinical research resources of the OHSU Clinical and Translational Research Center, which facilitates training in state-of-the-art clinical investigation. 3) The outstanding environment for research in both clinical as well as cellular and molecular endocrinology and related areas at OHSU and its affiliated institutions (Vollum Institute and Oregon National Primate Research Center). A major premise of the training program is that the need for skilled physician-investigators will only continue to increase over the coming decades and is critical for continued advancements in human health care.

Public Health Relevance

This program seeks to train independent academic endocrinologists who will function as independent laboratory scientists capable of developing research programs that address endocrine disorders in the future.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007674-20
Application #
8507716
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1999-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
20
Fiscal Year
2013
Total Cost
$256,228
Indirect Cost
$19,644
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Caputo, Nicholas; Jackson, Melanie A; Castle, Jessica R et al. (2014) Biochemical stabilization of glucagon at alkaline pH. Diabetes Technol Ther 16:747-58
Swanson, Christine M; Nielson, Carrie M; Shrestha, Smriti et al. (2014) Higher 25(OH)D2 is associated with lower 25(OH)D3 and 1,25(OH)2D3. J Clin Endocrinol Metab 99:2736-44
McGee, W K; Bishop, C V; Bahar, A et al. (2012) Elevated androgens during puberty in female rhesus monkeys lead to increased neuronal drive to the reproductive axis: a possible component of polycystic ovary syndrome. Hum Reprod 27:531-40
Gardner, Samantha; Alzhanov, Damir; Knollman, Paul et al. (2011) TGF-? inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II. Mol Endocrinol 25:128-37
Xu, Fuhua; Stouffer, Richard L; Muller, Jorg et al. (2011) Dynamics of the transcriptome in the primate ovulatory follicle. Mol Hum Reprod 17:152-65
El Youssef, Joseph; Castle, Jessica R; Branigan, Deborah L et al. (2011) A controlled study of the effectiveness of an adaptive closed-loop algorithm to minimize corticosteroid-induced stress hyperglycemia in type 1 diabetes. J Diabetes Sci Technol 5:1312-26
El Youssef, Joseph; Castle, Jessica R; Engle, Julia M et al. (2010) Continuous glucose monitoring in subjects with type 1 diabetes: improvement in accuracy by correcting for background current. Diabetes Technol Ther 12:921-8
Chia, Dennis J; Varco-Merth, Ben; Rotwein, Peter (2010) Dispersed Chromosomal Stat5b-binding elements mediate growth hormone-activated insulin-like growth factor-I gene transcription. J Biol Chem 285:17636-47
Castle, Jessica R; Ward, W Kenneth (2010) Amperometric glucose sensors: sources of error and potential benefit of redundancy. J Diabetes Sci Technol 4:221-5
Castle, Jessica R; Engle, Julia M; El Youssef, Joseph et al. (2010) Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes. Diabetes Care 33:1282-7

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