This application proposes continued funding for an interdisciplinary research training program in kidney diseases, hypertension, and cell biology. The purpose of this program is to provide training for young clinicians and scientists interested in pursuing research careers involved in diseases of the kidney, regulation of the blood pressure, and basic aspects of cell biology as they relate to kidney physiology and disease. The goals of the program are 1) To identify and recruit outstanding trainees, inclusive of gender and ethnicity, who wish to obtain comprehensive knowledge of the principles and techniques of basic and applied research related to kidney disease, hypertension, and cell biology;2) To offer training in the design and implementation of high quality research projects, including participation in cross-disciplinary research teams;3) To provide multidisciplinary and integrated mentored research experiences which facilitate developing a trainee's professional career;4) To increase the pool of well- trained researchers in diseases relating to the kidney who will create self-sustaining, innovative research programs and effectively participate in training related to kidney research. Trainees will be attracted from programs in urology, pediatric nephrology, nephrology, and the basic sciences. The major theme of the program is to provide the means whereby highly motivated young physicians and scientists can spend an intensive and sustained period of research training under the guidance of an established and productive faculty mentor. All trainees will have a mentoring committee in addition to their primary mentor. Specific training opportunities include the areas of basic and applied cell biology, abnormalities of the cardiovascular and renal systems in hypertension, developmental biology of the kidney, the biology of urogenital cancer, immunological disorders of the kidney, and clinical and translational investigation of diseases of the kidney and urinary tract. Additional opportunities will be available in related areas of physiology, biochemistry, pharmacology, and immunology. In addition, applicants will have the opportunity to work with investigators using epidemiologic and statistical methods. Over 30 faculty have indicated a willingness to participate in the trainin of such postdoctoral candidates. A broad range of highly specialized expertise permits such training in almost any area related to kidney diseases.
Kidney disease is a growing problem among people in the United States. The reasons for this increase are not completely known and most kidney disease is poorly understood. Therapies for kidney disease include dialysis and kidney transplantation, but these therapies are imperfect. This application proposes to continue a program to train scientists in the study of kidney disease, high blood pressure, and the biology of cells of the kidney. It includes training scientists in clinical problems including the epidemiology of diseases and how to translate discoveries in the laboratory into better therapies. A better understanding of kidney diseases may lead to better treatments and a healthier population.
|Stilley, Julie A W; Christensen, Debora E; Dahlem, Kristin B et al. (2014) FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice. Biol Reprod 91:74|
|Stilley, Julie A; Guan, Rongbin; Duffy, Diane M et al. (2014) Signaling through FSH receptors on human umbilical vein endothelial cells promotes angiogenesis. J Clin Endocrinol Metab 99:E813-20|
|Goddeeris, Matthew M; Wu, Biming; Venzke, David et al. (2013) LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy. Nature 503:136-40|
|Shields, S Brookhart; Piper, Robert C (2011) How ubiquitin functions with ESCRTs. Traffic 12:1306-17|
|Matsuda, James J; Filali, Mohammed S; Collins, Malia M et al. (2010) The ClC-3 Cl-/H+ antiporter becomes uncoupled at low extracellular pH. J Biol Chem 285:2569-79|
|Matsuda, James J; Filali, Mohammed S; Moreland, Jessica G et al. (2010) Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. J Biol Chem 285:22864-73|
|Grobe, Justin L; Dickson, Matthew E; Park, Sungmi et al. (2010) Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. Hypertension 56:981-7|
|Matsuda, James J; Filali, Mohammed S; Volk, Kenneth A et al. (2008) Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent. Am J Physiol Cell Physiol 294:C251-62|
|Boddicker, Jennifer D; Anderson, Rebecca A; Jagnow, Jennifer et al. (2006) Signature-tagged mutagenesis of Klebsiella pneumoniae to identify genes that influence biofilm formation on extracellular matrix material. Infect Immun 74:4590-7|