This application requests continued funding for an innovative and highly successful T32 training program in Pediatric Nephrology at Cincinnati Children's Hospital Medical Center. The training program, funded by the NIH since 1975, has consistently produced much-needed academic pediatric nephrologists. Through a combination of supervised research, core seminars and graduate level courses, and dedicated mentorship provided by a consortium of primary research mentors and an advisory committee, trainees have a unique opportunity to develop outstanding skills and leadership in the following four areas critical to the field: """""""" Molecular Biology of Kidney Development (Aronow, Greis, Kopan, Potter) """""""" Translational Studies in Acute Kidney Injury (Brunner, Davies, Devarajan, Goldstein, Robbins, Wong) """""""" Clinical Epidemiology of Pediatric Kidney Disease (Macaluso, Mitsnefes, Vinks) """""""" Quality Improvement in Pediatric Kidney Disease (Goebel, Margolis) Trainees in the basic sciences have a strong basic science component to their supervised research and required courses. The depth and quality of this exposure is monitored by an interdisciplinary team of outstanding scientists with strong training and mentoring track records. Fellows in the clinical sciences have highly experienced clinical investigators, and will complete a Masters in Biostatistics and Epidemiology. All trainees have a formal and in-depth exposure to research ethics, biostatistics, and research design. In addition to training fellows, the primary research mentors are also committed to training young faculty to be future mentors (mentors-in-training program). The long-term goal of the program remains to foster the development of outstanding clinical or basic science physician-investigators and leaders who will meet the tremendously underserved academic workforce needs in Pediatric Nephrology. Major strengths of this program include the long-standing track record and commitment to excellence in fellowship training provided by the institution and division.

Public Health Relevance

Pediatric kidney diseases due to developmental abnormalities, acute kidney injury, and acquired chronic kidney diseases contribute to an enormous major impact on the U.S. public health and a major financial burden. This T32 will train the next generation of academic pediatric nephrologists. The established and highly successful training program at our institution continues to vigorously serve the community by graduating at least two exceptionally well trained fellows each year, fully competent in clinical care, research, education, leadership, and citizenship.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
United States
Zip Code
Siroky, Brian J; Kleene, Nancy K; Kleene, Steven J et al. (2017) Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3. Am J Physiol Renal Physiol 312:F791-F805
Laskin, Benjamin L; Mitsnefes, Mark M; Dahhou, Mourad et al. (2015) The mortality risk with graft function has decreased among children receiving a first kidney transplant in the United States. Kidney Int 87:575-83
Laskin, Benjamin L; Denburg, Michelle; Furth, Susan et al. (2013) BK viremia precedes hemorrhagic cystitis in children undergoing allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 19:1175-82
Dawoud, Dalia; Lyndon, Will; Mrug, Sylvie et al. (2012) Impact of ultrasound-guided kidney biopsy simulation on trainee confidence and biopsy outcomes. Am J Nephrol 36:570-4
Laskin, B L; Goebel, J (2010) Cost-efficient screening for BK virus in pediatric kidney transplantation: a single-center experience and review of the literature. Pediatr Transplant 14:589-95
Mrug, Michal; Bissler, John J (2010) Simulation of real-time ultrasound-guided renal biopsy. Kidney Int 78:705-7