This training grant in developmental endocrinology and metabolism at Children's Hospital Boston intends to provide funding for postdoctoral fellows to engage in research training leading to independent careers in academic pediatric endocrinology. Trainees enter the program with either the MD, MD/PhD or occasionally the PhD degree, and are selected from highly qualified pediatric endocrinology fellows at Children's Hospital. The 28 trainers include 13 pediatric endocrine physician-scientists (including 5 MD/PhDs), 13 physician-scientists of other disciplines, and 2 PhD scientists. Children's Hospital is the major training site, along with laboratories at Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, and Joslin Diabetes Center. The major areas of research emphasis in this training grant include clinical, translational and basic laboratory research in diabetes mellitus, obesity, neuroendocrinology, thyroid disease, bone health, stem cell biology, bioinformatics, ion transport, and human outcomes research. Training consists of didactic courses, including in quantitative methods and the ethical conduct of research, and an intensive period of individually mentored research. The intended average duration of training is two years. Of the 15 trainees during the past 10 years who have completed this training program, all but 1 are faculty in academic pediatric institutions (1 Professor, 2 Assistant Professors, 9 Instructors) and 2 are in industry. Of these, 3 have had independent NIH K awards, and 1 has an R01. Their record of publication is strong. This program takes advantage of the breadth of scientific expertise of the training faculty within the Division of Endocrinology, as well as in the larger Children's Hospital Boston community and surrounding Harvard environment.

Public Health Relevance

This application aims to foster the training of a diverse and exceptionally well-trained group of postdoctoral fellows entering the field of pediatric endocrinology research through a training grant program at Children's Hospital Boston. To meet the growing biomedical research needs for pediatric endocrinology, each year we will provide training and support for 4 postdoctoral trainees for up to 2 years in this pediatric endocrinology training program. Based upon the extensive research programs of our faculty, and our record of successful career development of pediatric endocrinologists becoming independent researchers, we aim to support the training of a new group of pediatric endocrinology trainees who will become future leaders of academic pediatric research programs in the United States.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital Boston
United States
Zip Code
Swartz, Jonathan M; Ciarlo, Ryan; Guo, Michael H et al. (2016) Two Unrelated Undervirilized 46,XY Males with Inherited NR5A1 Variants Identified by Whole-Exome Sequencing. Horm Res Paediatr :
Zhang, R; Asai, M; Mahoney, C E et al. (2016) Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice. Mol Psychiatry :
Brady, Cassandra C; Thaker, Vidhu V; Lingren, Todd et al. (2016) Suboptimal Clinical Documentation in Young Children with Severe Obesity at Tertiary Care Centers. Int J Pediatr 2016:4068582
Thaker, Vidhu V; Lee, Felix; Bottino, Clement J et al. (2016) Impact of an Electronic Template on Documentation of Obesity in a Primary Care Clinic. Clin Pediatr (Phila) 55:1152-9
Soto-Rivera, Carmen L; Schwartz, Steven M; Sawyer, Jaclyn E et al. (2016) Endocrinologic Diseases in Pediatric Cardiac Intensive Care. Pediatr Crit Care Med 17:S296-301
Tyrrell, Jessica; Jones, Samuel E; Beaumont, Robin et al. (2016) Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. BMJ 352:i582
Jagannath, Vanitha A; Fedorowicz, Zbys; Thaker, Vidhu et al. (2015) Vitamin K supplementation for cystic fibrosis. Cochrane Database Syst Rev 1:CD008482
Thaker, Vidhu V; Esteves, Kristyn M; Towne, Meghan C et al. (2015) Whole exome sequencing identifies RAI1 mutation in a morbidly obese child diagnosed with ROHHAD syndrome. J Clin Endocrinol Metab 100:1723-30
Jagannath, Vanitha A; Fedorowicz, Zbys; Thaker, Vidhu et al. (2015) Vitamin K supplementation for cystic fibrosis. Cochrane Database Syst Rev 1:CD008482
Soto-Rivera, Carmen L; Fichorova, Raina N; Allred, Elizabeth N et al. (2015) The relationship between TSH and systemic inflammation in extremely preterm newborns. Endocrine 48:595-602

Showing the most recent 10 out of 41 publications