This Training Grant in Pediatric Gastroenterology is designed to provide an intensive basic or patient based research experience that is essential to prepare clinician-scientists for productive and independent careers in academic and investigative medicine. The Program has a demonstrated track record of recruiting well-trained clinicians and providing them with research opportunities, an educational curriculum and mentoring to enable them to achieve successful academic careers. The program will support 7 postdoctoral fellows at Cincinnati Children's Hospital Medical Center. These fellows will spend two years with a Faculty Advisor in the laboratory or a structured clinical research program. The Faculty Advisors consist of 44 investigators with research interests relevant to pediatric gastroenterology. The thematic focus areas central to the Program: are 1) Chronic liver disease, 2) Digestive organ (liver and intestinal) failure and transplantation, 3) Inflammatory and diarrheal diseases, and 4) Obesity. The presence of a fully aligned Digestive Disease Research Core Center (PSO) further enhances the academic environment and focus of the training program. The Faculty has a demonstrated record of productive collaboration and extramural funding. A group of well- qualified prospective (associate) Faculty Advisors has also been identified to ensure continued growth of the program. The Administrative Core of the Program includes a Program Director and Associate Program Director (co-PI) who work both together both strategically and operationally to ensure a strong program. Didactic course work is required for trainees in both basic and clinical research and this is supplemented with appropriate seminars, journal clubs, a course in the responsible conduct of research, and other enrichment offerings. Those learning how to perform patient based research are expected to complete a Master of Science Degree. The record of our Trainees in staying in academic medicine (75%), and performing research (61%) is a measure of our success. We have also fulfilled our commitment to training women (44%) and minorities (22%). There is a pool of highly qualified candidates applying to and/or already committed to entering our clinical training program. Thus, when considered with our institutional resources and past success, the Program is poised to extend the training opportunities to increase the number new investigators in Pediatric Gastroenterology.

Public Health Relevance

There is a critical shortage of investigators in pediatric gastroenterology who can advance new knowledge to improve the outcomes for children with digestive diseases. Our training program focuses on 1) Chronic liver disease, 2) Liver and intestinal failure and transplantation, 3) Inflammatory bowel disease, eosinophilic gastrointestinal and diarrheal disorders, and 4) Obesity. We will provide mentored training to pediatricians who will become the next generation of investigators in pediatric gastroenterology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007727-17
Application #
8090349
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1995-01-01
Project End
2015-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
17
Fiscal Year
2011
Total Cost
$428,585
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
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Carey, Alexandra N; Zhang, Wujuan; Setchell, Kenneth D R et al. (2017) Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates. Pediatr Res 82:122-132
Miloh, Tamir; Barton, Andrea; Wheeler, Justin et al. (2017) Immunosuppression in pediatric liver transplant recipients: Unique aspects. Liver Transpl 23:244-256
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Mezoff, Ethan A; Lin, Tom K; Kaul, Ajay et al. (2017) A Procedural and Educational Experience Following Creation of an Advanced Pediatric Endoscopy Service. J Pediatr Gastroenterol Nutr 64:e96-e99
Valencia, C Alexander; Wang, Xinjian; Wang, Jin et al. (2016) Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism. PLoS One 11:e0156738
Mezoff, Ethan A; Hawkins, Jennifer A; Ollberding, Nicholas J et al. (2016) The human milk oligosaccharide 2'-fucosyllactose augments the adaptive response to extensive intestinal. Am J Physiol Gastrointest Liver Physiol 310:G427-38
Miethke, Alexander G; Zhang, Wujuan; Simmons, Julia et al. (2016) Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice. Hepatology 63:512-23
Peters, Anna L (2016) 50 Years Ago in TheJournal ofPediatrics: Extrahepatic Biliary Atresia: Comments on the Frequency of Potentially Operable Cases. J Pediatr 174:246
Galloway, David P; Wallihan, Daniel; Smith, Milton T et al. (2016) An Unusual Presentation of Pediatric Autoimmune Pancreatitis. Pancreas 45:e1-2

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