The incidence and prevalence of treated end-stage renal disease (ESRD) has increased relentlessly in the U.S. since initiation of the Medicare ESRD Program in 1973. Many more Americans have less severe forms of chronic kidney disease. Thus there is a national need to train more scientists to study this societal health problem. Renal disease epidemiology offers the potential to help reduce the morbidity, mortality and societal costs associated with kidney disease and is a natural complement to the substantial strengths in basic science research in renal disease. This proposal is a competitive renewal application, years 16 to 20, for a NRSA to fund a Renal Disease Epidemiology Training Program at The Johns Hopkins Medical Institutions. The Program is based in the Welch Center for Prevention, Epidemiology, and Clinical Research and the Department of Epidemiology;it takes advantage of the faculty's strengths in the application of epidemiologic methods to important issues in renal disease and their ability to bridge the disciplines of basic science and epidemiology. A program Director (Dr. Klag), co-director (Dr. Appel), and 10 other nationally recognized renal disease epidemiologists serve as faculty advisers;3 other faculty with experience in renal disease epidemiology are also available for mentorship. An Advisory Committee of institutional leaders and internationally recognized researchers advise the directors and monitor progress. We have demonstrated our ability to recruit high quality candidates and rigorously train them in clinical and epidemiologic renal research methods. Over the last 10 years, a total of 18 trainees have been supported, 5 of whom are still in training. Of the remaining 13, 12 are pursuing academic careers. These trainees have published 155 papers. This funding has revitalized the Pediatric Nephrology fellowship at our institution, forged close collaborative relations between the participating units, and produced a cadre of successful young investigators who are doing innovative research at Johns Hopkins and other institutions across the US..

Public Health Relevance

This program provides rigorous training in statistics, epidemiology, and clinical research methods to future leaders who will find new ways to prevent and treat kidney disease. The faculty and trainees form collaborations and use state-of-the art methods to characterize risk factors, including genes, for kidney disease as well as to design and carry out clinical trials. This program has profoundly influenced the curriculum and research agenda of the Johns Hopkins Medical Institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007732-19
Application #
8512704
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
1995-09-20
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
19
Fiscal Year
2013
Total Cost
$291,610
Indirect Cost
$18,600
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Grams, Morgan E; Li, Liang; Greene, Tom H et al. (2015) Estimating time to ESRD using kidney failure risk equations: results from the African American Study of Kidney Disease and Hypertension (AASK). Am J Kidney Dis 65:394-402
Johns, Tanya S; Estrella, Michelle M; Crews, Deidra C et al. (2014) Neighborhood socioeconomic status, race, and mortality in young adult dialysis patients. J Am Soc Nephrol 25:2649-57
Lestz, Rachel M; Fivush, Barbara A; Atkinson, Meredith A (2014) Association of higher erythropoiesis stimulating agent dose and mortality in children on dialysis. Pediatr Nephrol 29:2021-8
Scialla, Julia J; Kao, W H Linda; Crainiceanu, Ciprian et al. (2014) Biomarkers of vascular calcification and mortality in patients with ESRD. Clin J Am Soc Nephrol 9:745-55
Chang, Alex R; Grams, Morgan E (2014) Serum phosphorus and mortality in the Third National Health and Nutrition Examination Survey (NHANES III): effect modification by fasting. Am J Kidney Dis 64:567-73
Chang, Alex R; Lazo, Mariana; Appel, Lawrence J et al. (2014) Reply to MF McCarty. Am J Clin Nutr 99:966-7
Chang, Alex R; Lazo, Mariana; Appel, Lawrence J et al. (2014) High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III. Am J Clin Nutr 99:320-7
Dahlinghaus, Erin K; Neu, Alicia M; Atkinson, Meredith A et al. (2014) Hemoglobin level and risk of hospitalization and mortality in children on peritoneal dialysis. Pediatr Nephrol 29:2387-94
Chang, Alexander; Anderson, Emily E; Turner, Hang T et al. (2013) Identifying potential kidney donors using social networking web sites. Clin Transplant 27:E320-6
Chang, Alex; Van Horn, Linda; Jacobs Jr, David R et al. (2013) Lifestyle-related factors, obesity, and incident microalbuminuria: the CARDIA (Coronary Artery Risk Development in Young Adults) study. Am J Kidney Dis 62:267-75

Showing the most recent 10 out of 51 publications