This is a competitive renewal application for a 15 year T32 program to train postdoctoral fellows in gastrointestinal basic scientific research by 19 highly selected interdisciplinary faculty mentors drawn from the Center for Gastrointestinal Biology and Disease (CGIBD). The primary goal of this program is to develop the future academic and scientific leaders of gastroenterology by training promising MD, MD/PhD, DVM/PhD and PhD postdoctoral fellows to become independent investigators. A diverse, extensive training program helps our trainees develop new insights into the pathogenesis of gastrointestinal diseases and perform basic and translational research to identify novel diagnostic and treatment approaches. We propose to continue supporting two new postdoctoral fellows each year for 2 years of full time lab-based research (total of four postdoctoral fellows/year). We recruit MD research gastroenterology fellows and PhD postdoctoral fellows, with an equal distribution of MD and PhD trainees. We have a comprehensive, interactive training program that integrates trainees of different backgrounds to broaden the educational experience of all participants. The effectiveness of this integrated training program is proven by results: 18 of our 24 trainees over the past 10 years have obtained academic positions or are currently continuing their training. We have filled our full complement of trainees for each year of funding with exceptionally well qualified investigators who are actively engaged in basic GI research under highly qualified mentors. Our T32 training program has undergone continued evolution since the last competitive renewal in 2006 that has improved our ability to prepare trainees for independent research careers. We have recruited Susan Henning, PhD as co-director after she moved to UNC in 2007 from Baylor College of Medicine, where she ran a highly effective Pediatric GI training program for 18 years. In addition, we have created a more cohesive program with more frequent interaction among the T32 trainees, a formal research committee for all MD trainees and a Mentor in Training program. Finally, we have appointed extremely talented trainees and maintained an equal balance between MD and PhD trainees over the past funding cycle. One incoming MD trainee is from an underrepresented racial group, showing our successful recruitment of minorities.

Public Health Relevance

This is a competitive renewal application for a 15 year T32 program to train postdoctoral fellows in gastrointestinal basic scientific research by 19 highly experienced interdisciplinary faculty mentors. The primary goal of this program is to develop the future academic and scientific leaders of gastroenterology by training promising MD, MD/PhD, DVM/PhD and PhD postdoctoral fellows to become independent investigators. A diverse, extensive training program helps our trainees develop new insights into the pathogenesis of gastrointestinal diseases and perform basic and translational research to identify novel diagnostic and treatment approaches. Relevance to Public Health Our comprehensively trained postdoctoral fellows are prepared to perform multidisciplinary research that can be applied to investigate basic pathogenesis of GI diseases and development of novel treatment and diagnostic approaches. Our Ph.D. and M.D. trainees are trained in laboratory based research, digestive disease pathogenesis and normal GI physiology, so that they can perform translational research relevant to important human gastrointestinal diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007737-19
Application #
8730595
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1996-08-01
Project End
2016-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
19
Fiscal Year
2014
Total Cost
$210,130
Indirect Cost
$18,804
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Yu, Ai-Ming; Ingelman-Sundberg, Magnus; Cherrington, Nathan J et al. (2017) Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO). Acta Pharm Sin B 7:241-248
Carr, Jacquelyn S; King, Stephanie; Dekaney, Christopher M (2017) Depletion of enteric bacteria diminishes leukocyte infiltration following doxorubicin-induced small intestinal damage in mice. PLoS One 12:e0173429
Bhatt, Aadra P; Redinbo, Matthew R; Bultman, Scott J (2017) The role of the microbiome in cancer development and therapy. CA Cancer J Clin 67:326-344
Jorgensen, Ine; Rayamajhi, Manira; Miao, Edward A (2017) Programmed cell death as a defence against infection. Nat Rev Immunol 17:151-164
Pollet, Rebecca M; D'Agostino, Emma H; Walton, William G et al. (2017) An Atlas of ?-Glucuronidases in the Human Intestinal Microbiome. Structure 25:967-977.e5
Purcell, Erin B; McKee, Robert W; Courson, David S et al. (2017) A Nutrient-Regulated Cyclic Diguanylate Phosphodiesterase Controls Clostridium difficile Biofilm and Toxin Production during Stationary Phase. Infect Immun 85:
Jorgensen, Ine; Lopez, Joseph P; Laufer, Stefan A et al. (2016) IL-1?, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis. Eur J Immunol 46:2761-2766
Purcell, Erin B; McKee, Robert W; Bordeleau, Eric et al. (2016) Regulation of Type IV Pili Contributes to Surface Behaviors of Historical and Epidemic Strains of Clostridium difficile. J Bacteriol 198:565-77
Koblansky, A Alicia; Truax, Agnieszka D; Liu, Rongrong et al. (2016) The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals. Cell Rep 14:2562-75
Rigby, Rachael J; Carr, Jacquelyn; Orgel, Kelly et al. (2016) Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis. Gut Microbes 7:414-23

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