The goal of the Interdepartmental Training Program in Cellular and Molecular Endocrinology at Johns Hopkins is to expand the pool of well-trained and productive investigators in the biomedical sciences related to endocrinology. The Program Directors work with a Steering Committee to choose candidates from two pools of talented individuals: 1) endocrine fellows who have completed one year of clinical training, and 2) M.D., M.D.&Ph.D. or Ph.D. applicants who have an interest in fundamental laboratory training. The environment for research related to endocrinology at Johns Hopkins University is rich with resources including the Divisions of Adult and Pediatric Endocrinology and Metabolism, the depth and breadth of related research in the basic sciences, the JHU-UMD Diabetes Research Center (DRTC), the Institute for Clinical and Translational Research (ICTR, funded by the CTSA), and the Center for Metabolism and Obesity Research. The program has been able to recruit the most qualified candidates through a process that stresses diversity. Selection is based not only on the individual's qualifications and interests, but also on their potential and commitment to applying fundamental science to clinical problems. The mentoring program is structured with a strong fundamental knowledge base that is individually tailored for basic and translational research in endocrinology. The training program consists of at least two years of research under the direction of the most qualified and talented mentors at Johns Hopkins in endocrinology and relevant disciplines. Trainees participate in an innovative didactic curriculum that consists of research seminars, data/journal clubs, and formal courses. Fellows will also be trained in the ethical conduct of research, have well defined milestones for accomplishing scientific goals, and have regular meetings with mentors, the steering committee and others in the scientific community. Training programs in written and oral communication and leadership are instituted as well as an evaluation system for fellows and mentors. The availability of the ICTR and mentors with translational research protocols provides trainees with an opportunity to develop clinical research protocols that complement their laboratory studies. The major goal of this program is to train academic endocrinologists who function as independent laboratory scientists creating research plans that address contemporary endocrine problems. Anticipated outcomes include excellence in training, understanding and coherently articulating, in the form of grant proposals, the scientific challenges and clinical translation in endocrinology, and competency in manuscript writing. With these elements, we commit to continue nurturing a cadre of potential faculty that will discover and expand knowledge and become future leaders in the field of endocrinology.
The incidence of endocrine disorders, including diabetes and obesity, has experienced a striking increase in children and adults at a time when there is a critical, severe shortage of qualified endocrinologists. This award proposes to fund a training program to develop the next generation of physician-scientists in research in endocrinology. Johns Hopkins University School of Medicine has the resources required to foster the training and career development of physician-scientists who are poised to undertake these research challenges.
|Salehi, Sajad; Adeshina, Ikeoluwa; Chen, Haolin et al. (2015) Developmental and endocrine regulation of kisspeptin expression in mouse Leydig cells. Endocrinology 156:1514-22|
|Mathioudakis, Nestoras; Sundaresh, Ram; Larsen, Alexandra et al. (2015) Expression of the pituitary stem/progenitor marker GFRÎ±2 in human pituitary adenomas and normal pituitary. Pituitary 18:31-41|
|Wolf, Risa M; Steele, Kimberley E; Peterson, Leigh A et al. (2015) Lower Circulating C1q/TNF-Related Protein-3 (CTRP3) Levels Are Associated with Obesity: A Cross-Sectional Study. PLoS One 10:e0133955|
|Petersen, Pia S; Lei, Xia; Seldin, Marcus M et al. (2014) Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels. Am J Physiol Regul Integr Comp Physiol 307:R1458-70|
|Crane, Janet L; Cao, Xu (2014) Bone marrow mesenchymal stem cells and TGF-Î² signaling in bone remodeling. J Clin Invest 124:466-72|
|Crane, Janet L; Cao, Xu (2014) Function of matrix IGF-1 in coupling bone resorption and formation. J Mol Med (Berl) 92:107-15|
|Byerly, Mardi S; Petersen, Pia S; Ramamurthy, Santosh et al. (2014) C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. J Biol Chem 289:4055-69|
|Byerly, Mardi S; Swanson, Roy D; Wong, G William et al. (2013) Stage-specific inhibition of TrkB activity leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression. PLoS One 8:e80781|
|Byerly, Mardi S; Swanson, Roy D; Wong, G William et al. (2013) Estrogen-related receptor Î² deficiency alters body composition and response to restraint stress. BMC Physiol 13:10|
|Li, Changjun; Xing, Qiujuan; Yu, Bing et al. (2013) Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH. J Bone Miner Res 28:2094-108|
Showing the most recent 10 out of 47 publications