This is a competing continuation application for renewal of a training program in gastroenterology that was first funded in 1999. Since then, 20 trainees have been supported, of whom all but four are in full time academic positions, or full-time research in industry, or still in training. The goal of this program is to provide two or three years of research training for young researchers committed to a career in investigative gastroenterology or allied fields. The types of research training include basic, translational or clinical research, or combinations of these. Trainees may be MDs, MD-PhDs or PhDs who have finished clinical or graduate training and are seeking further research training in gastroenterology. Training will consist primarily of mentored research that will provide intense hands-on experience. An extensive menu of didactic courses, workshops, seminars and conferences will also be provided. Trainees in patient-oriented research will be expected to complete course work and thesis requirements to obtain an MMS, MPH or equivalent degree. All trainees will be expected to submit grant applications for K-series NIH awards or support from research foundations during the 3rd year of research training. Trainees will be supervised by experienced research mentors with a wide range of interests and expertise from basic cellular and molecular biology to clinical research. A training committee composed of Drs. Kelly, Robson, Terhorst and Lament and one or two other training faculty will monitor the overall research training program, select suitable candidates and monitor progress. Trainee research programs will be available in four broad areas that are integrated with clinical centers of excellence in the Division: 1.) Intestinal Infection and Immunity 2.) Liver Injury and Fibrosis 3.) Vascular Biology and 4.) Epithelial Biology. The training program will take advantage of the outstanding Gl research base within the Gl Division, the Departments of Medicine and Surgery and at harvard Medical School and School of Public Health. The training program will also benefit from the availability of a well organized and funded General Clinical Research Center at BIDMC, as well as the close proximity of two Digestive Disease Centers, one at Harvard Medical School and a second at Massachusetts General Hospital. The Gl Division has a good track record of recruitment of female and minority trainees and faculty, and has an active plan for future minority outreach and recruitment.

Public Health Relevance

This program will address a critical issue in medicine in general and gastroenterology in particular: the dwindling supply of well-trained physician-scientists and basic researchers focused on Gl and liver diseases. The program will integrate bench research with clinical questions and problems to better address the information gaps in diagnosis and treatment in our specialty. Our ultimate goal is to produce individuals who are able to compete successfully for start-up research funding and for entry level faculty positions and who continue to exhibit a substantial commitment to basic or clinical research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007760-15
Application #
8510626
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1999-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
15
Fiscal Year
2013
Total Cost
$265,203
Indirect Cost
$19,826
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Liao, Gongxian; van Driel, Boaz; Magelky, Erica et al. (2014) Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine. FASEB J 28:474-84
Vaughn, Byron P; Martinez-Vazquez, Manuel; Patwardhan, Vilas R et al. (2014) Proactive therapeutic concentration monitoring of infliximab may improve outcomes for patients with inflammatory bowel disease: results from a pilot observational study. Inflamm Bowel Dis 20:1996-2003
Fisher, Ffolliott M; Chui, Patricia C; Nasser, Imad A et al. (2014) Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology 147:1073-83.e6
Vaughn, Byron P; Shah, Sveta; Cheifetz, Adam S (2014) The role of mucosal healing in the treatment of patients with inflammatory bowel disease. Curr Treat Options Gastroenterol 12:103-17
Vaughn, Byron Philip; Moss, Alan Colm (2014) Prevention of post-operative recurrence of Crohn's disease. World J Gastroenterol 20:1147-54
Bai, Aiping; Moss, Alan; Kokkotou, Efi et al. (2014) CD39 and CD161 modulate Th17 responses in Crohn's disease. J Immunol 193:3366-77
Ketwaroo, Gyanprakash A; Sheth, Sunil (2013) Autoimmune Pancreatitis. Gastroenterol Rep 1:27-32
Ketwaroo, Gyanprakash; Brown, Alphonso; Young, Benjamin et al. (2013) Defining the accuracy of secretin pancreatic function testing in patients with suspected early chronic pancreatitis. Am J Gastroenterol 108:1360-6
LeBleu, Valerie S; Taduri, Gangadhar; O'Connell, Joyce et al. (2013) Origin and function of myofibroblasts in kidney fibrosis. Nat Med 19:1047-53
Ketwaroo, Gyanprakash A; Cheng, Vivian; Lembo, Anthony (2013) Opioid-induced bowel dysfunction. Curr Gastroenterol Rep 15:344

Showing the most recent 10 out of 29 publications