The goal of the Research Training in Digestive Diseases Program at the University of Virginia continues to be the development of young investigators in gastroenterology and hepatology. The foundation of this training program, now in its 10th year, is a robust multidisciplinary research environment. The program is designed to produce successful and well-trained academic investigators in digestive diseases. Key elements of the post-doctoral training curriculum include participation in basic, translational and clinical research and a comprehensive program of didactic instruction and enrichment activities aimed at providing a solid foundation in biomedical sciences as well as the latest research techniques. Research Areas and Disciplines: The broad range of research interests of the program faculty are unified by a core of related disciplines, which are common to every trainee's experience. Trainees pursuing training in laboratory research will learn to apply the tools of molecular and cell biology, genetics, physiology and/or immunology to important Gl questions. For the trainees pursuing clinical investigation, a rigorous curriculum in quantitative sciences, including Outcomes Research, Biostatistics, Epidemiology, and Clinical Trials is available in collaboration with the Public Health Sciences faculty. The expertise of the program faculty mentors and the key areas of research offered by the Training Program fall into five overlapping and interactive areas of research: IBD and inflammation;Gl infections;Cancer and regeneration;Pancreatobiliary and liver diseases;and Clinical and translational studies and genetics. Trainees: This continuation application is focused on post-doctoral training offered to individuals holding MD, PhD, or related degrees. Three post-doctoral positions per year for five years are requested, with three beginning training each year and remaining in training supported by this award for a minimum of two years. Research training will take place in the laboratories of the research mentors, a group of 26 established investigators with extensive collaborative interactions. Accomplishments: Over the past 10 years this training grant has been instrumental in developing investigators of digestive health research. During the past 5-year funding period, we have supported 11 trainees. 4 are currently still engaged in training. 5 of the 7 individuals who have finished training in this past funding period are in academic positions as instructors (1) or assistant professors (4). 2 of our 19 trainees over the past decade of funding have been women and 3 minorities. All three trainees currently supported by the T32 grant are planning to pursue careers in academic medicine.

Public Health Relevance

A comprehensive Training Program which aims to nurture and develop successful young researchers of digestive diseases will help ensure the future of gastroenterology and hepatology. The Training Program in Digestive Diseases at the University of Virginia has demonstrated success in that the majority of graduates from our program remain working in universities advancing knowledge of digestive health and disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007769-15
Application #
8683150
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1999-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
15
Fiscal Year
2014
Total Cost
$160,628
Indirect Cost
$13,915
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Stine, Jonathan G; Argo, Curtis K; Pelletier, Shawn J et al. (2016) Liver transplant recipients with portal vein thrombosis receiving an organ from a high-risk donor are at an increased risk for graft loss due to hepatic artery thrombosis. Transpl Int 29:1286-1295
Stine, Jonathan G; Pelletier, Shawn J; Schmitt, Timothy M et al. (2016) Pre-transplant portal vein thrombosis is an independent risk factor for graft loss due to hepatic artery thrombosis in liver transplant recipients. HPB (Oxford) 18:279-86
Maiden, Stephanie L; Petrova, Yuliya I; Gumbiner, Barry M (2016) Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. PLoS One 11:e0148574
Harakal, Jessica; Rival, Claudia; Qiao, Hui et al. (2016) Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis. J Immunol 197:27-41
Stine, Jonathan G; Wang, Jennifer; Behm, Brian W (2016) Chronic Cholestatic Liver Injury Attributable to Vedolizumab. J Clin Transl Hepatol 4:277-280
Stine, Jonathan G; Lewis, James H (2016) Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review. Expert Rev Gastroenterol Hepatol 10:517-36
Wang, Jennifer; Stine, Jonathan G; Cornella, Scott L et al. (2015) Patients with Gastric Antral Vascular Ectasia (GAVE) Are at a Higher Risk of Gastrointestinal Bleeding in the Absence of Cirrhosis. J Clin Transl Hepatol 3:254-9
Stine, Jonathan G; Shah, Puja M; Cornella, Scott L et al. (2015) Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis. World J Hepatol 7:2774-80
Stine, Jonathan G; Chalasani, Naga (2015) Chronic liver injury induced by drugs: a systematic review. Liver Int 35:2343-53
Ralston, Katherine S; Solga, Michael D; Mackey-Lawrence, Nicole M et al. (2014) Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion. Nature 508:526-30

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