This is a proposal from the University of Cincinnati College of Medicine (UCCOM) to renew its long-standing training program (T32 DK059803) that supports predoctoral and postdoctoral training in the neuroendocrinology of energy balance and hypothalamo-pituitary-adrenal (HPA) stress axis regulation, with an emergent focus upon the role of sex differences. The training grant fits well with and enhances the tremendous growth in neuroscience research in general, and neuroendocrinology in particular, enjoyed by the UCCOM over the years since our original submission. The faculty of the training program consists of highly qualified and well-funded investigators from diverse departments with a common interest in metabolic and stress homeostasis, and most of the faculty are located in contiguous space at the recently renovated Metabolic Diseases Institute (MDI) of the UCCOM. The primary purpose of our training structure is to enable students and fellows to understand and apply principles of homeostasis to their research, and to provide an environment that encourages students and fellows to explore research that involves more than one of the focus areas. In particular, we want to expose students to a broad array of advanced techniques that they can be incorporated into their ongoing and future research. The training for both pre- and post-doctoral trainees includes a blend of coursework, seminars and journal clubs, and extensive one-on-one instruction, and at all levels there is an emphasis upon ethics and the responsible conduct of research. We believe that we have achieved an outstanding record of accomplishment in terms of recruiting, training and placing highly qualified trainees, and that thi is particularly true for under- represented minority trainees. For this renewal application, we are requesting funding for 3 pre- doctoral students and 3 post-doctoral trainees as recommended by prior reviews. The pre- doctoral students will have passed their general exams and be supported for their doctoral thesis, and all trainees are anticipated to complete their training within 2 to 3 years.
Two of the major clinical concerns of modern society are related to dysfunctional metabolism (obesity;eating disorders) and stress responses (anxiety;mood disorders). The proposed training grant will prepare doctoral students and postdoctoral fellows to develop research careers in the regulation and overlap of these two problem areas with a special emphasis on women's health and sex differences.
| Egan, Ann E; Thompson, Abigail M K; Buesing, Dana et al. (2018) Palatable Food Affects HPA Axis Responsivity and Forebrain Neurocircuitry in an Estrous Cycle-specific Manner in Female Rats. Neuroscience 384:224-240 |
| Woods, Stephen C; May-Zhang, Aaron A; Begg, Denovan P (2018) How and why do gastrointestinal peptides influence food intake? Physiol Behav 193:218-222 |
| Strawn, Jeffrey R; Vollmer, Lauren L; McMurray, Katherine M J et al. (2018) Acid-sensing T cell death associated gene-8 receptor expression in panic disorder. Brain Behav Immun 67:36-41 |
| Packard, Amy E B; Di, Shi; Egan, Ann E et al. (2017) Sucrose-induced plasticity in the basolateral amygdala in a 'comfort' feeding paradigm. Brain Struct Funct 222:4035-4050 |
| Smith, Brittany L; Lyons, Carey E; Correa, Fernanda Guilhaume et al. (2017) Behavioral and physiological consequences of enrichment loss in rats. Psychoneuroendocrinology 77:37-46 |
| Goodson, M L; Packard, A E B; Buesing, D R et al. (2017) Chronic stress and Rosiglitazone increase indices of vascular stiffness in male rats. Physiol Behav 172:16-23 |
| May, Aaron A; Bedel, Nicholas D; Shen, Ling et al. (2016) Estrogen and insulin transport through the blood-brain barrier. Physiol Behav 163:312-321 |
| Smith, Brittany L; Schmeltzer, Sarah N; Packard, Benjamin A et al. (2016) Divergent effects of repeated restraint versus chronic variable stress on prefrontal cortical immune status after LPS injection. Brain Behav Immun 57:263-270 |
| Cassella, Sarah N; Hemmerle, Ann M; Lundgren, Kerstin H et al. (2016) Maternal immune activation alters glutamic acid decarboxylase-67 expression in the brains of adult rat offspring. Schizophr Res 171:195-9 |
| Myers, Brent; Carvalho-Netto, Eduardo; Wick-Carlson, Dayna et al. (2016) GABAergic Signaling within a Limbic-Hypothalamic Circuit Integrates Social and Anxiety-Like Behavior with Stress Reactivity. Neuropsychopharmacology 41:1530-9 |
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