This application is for renewal funding of research training in liver biology and disease at UCSF. The rationale is two-fold: (1) the field is growing rapidly and currently has insufficient numbers of well-trained investigators, and (2) the resources and environment at UCSF for training in liver research are exceptional. The program, which is based in the Division of Gastroenterology, provides two years of support to trainees who seek an intensive grounding towards a career as academic hepatologists. It is inter-disciplinary, encompassing the Department of Epidemiology and Biostatistics and the Liver Transplant Program for those undertaking clinical and outcomes research, and the UCSF Liver Center for those engaged in laboratory-based research. The mentor group comprises 13 faculty from the Departments of Medicine, Pathology, Biochemistry and Microbiology/Immunology. All have research programs in liver research, experience in training, and a record of working together. The program is overseen by a Steering Committee, which is responsible for screening applicants, tendering offers, and monitoring progress. Applications for admission will be solicited annually by national advertisement. The largest candidate pool will be M.D. applicants to the Investigator (research-intensive) track of the UCSF subspecialty program in Gastroenterology, but the process will be open to others including Ph.D.'s. The successful applicant will have a record of accomplishment in the form of publications and, in many cases, both M.D. and Ph.D. degrees. Applicants with a Ph.D. degree only must have a strong liver focus and orientation to translational research. The range of training within the program is broad, from clinical epidemiology, genetics, health outcomes and policy, to cell biology, organogenesis, immunology, host-pathogen interactions and fibrosis/carcinogenesis. Coincident with their research, trainees are provided formal instruction in basic and clinical sciences as part of the UCSF graduate programs in Clinical Research, Biomedical Sciences and Biological Sciences. A core curriculum encompassing ethical conduct of research and effective scientific communication is required of all students. Graduates of this research training in hepatology will be ready to assume a faculty-level position and to compete for individual extramural funding.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK060414-10
Application #
8080396
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
2001-12-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$241,367
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Ajmera, Veeral H; Terrault, Norah A; Harrison, Stephen A (2017) Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review. Hepatology 65:2090-2099
Perito, Emily R; Ajmera, Veeral; Bass, Nathan M et al. (2017) Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. Hepatol Commun 1:609-622
Saxena, Varun; Khungar, Vandana; Verna, Elizabeth C et al. (2017) Safety and efficacy of current direct-acting antiviral regimens in kidney and liver transplant recipients with hepatitis C: Results from the HCV-TARGET study. Hepatology 66:1090-1101
Pierce, Andrew A; Duwaerts, Caroline C; Siao, Kevin et al. (2017) CD18 deficiency improves liver injury in the MCD model of steatohepatitis. PLoS One 12:e0183912
Ajmera, Veeral; Perito, Emily R; Bass, Nathan M et al. (2017) Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease. Hepatology 65:65-77
Salazar, James; Saxena, Varun; Kahn, James G et al. (2017) Cost-Effectiveness of Direct-Acting Antiviral Treatment in Hepatitis C-Infected Liver Transplant Candidates With Compensated Cirrhosis and Hepatocellular Carcinoma. Transplantation 101:1001-1008
Sarkar, Monika; Wellons, Melissa; Cedars, Marcelle I et al. (2017) Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife. Am J Gastroenterol 112:755-762
Duwaerts, Caroline C; Amin, Amin M; Siao, Kevin et al. (2017) Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice. Cell Mol Gastroenterol Hepatol 4:223-236
Pierce, Andrew A; Duwaerts, Caroline C; Soon, Russell K et al. (2016) Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury. J Nutr Biochem 29:12-20
Ajmera, Veeral H; Gunderson, Erica P; VanWagner, Lisa B et al. (2016) Gestational Diabetes Mellitus Is Strongly Associated With Non-Alcoholic Fatty Liver Disease. Am J Gastroenterol 111:658-64

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