The Postdoctoral Training Program in Hepatology is an integral part of the robust liver-related research effort at UCSF. The purpose of the Program is to provide trainees a comprehensive background in liver biology and disease as well as the investigational skills to address new questions and contribute to new knowledge in hepatology. The Program is staffed by 13 faculty based within the Departments of Medicine, Surgery, Biochemistry and Microbiology &Immunology;collectively these individuals offer balanced expertise in basic and clinical hepatology and have a strong track record of working collaboratively with each other. A subgroup of 5 Program faculty comprise a Steering Committee charged with screening applicants, reviewing the training curriculum and monitoring the progress of active trainees. The top priority of the Program is to train physician- scientists who are admitted to UCSF as Gastroenterology fellows. MD applicants to the Program must have a prior record of research accomplishment and dedication to an independent investigative career in hepatology. PhD applicants are admitted largely from mentor laboratories;they must display similar academic promise and an orientation toward translational liver research. All trainees are placed through a core curriculum covering liver-related biology, liver-related research methods and general academic skills. They then undergo specialized research instruction under an individual mentor, with choices ranging from clinical epidemiology, health outcomes and genetics to cell biology, organogenesis, immunology, metabolism and fibrosis/carcinogenesis. Additional focused coursework is highly recommended for all trainees;for those pursuing clinical investigation, enrollment in a Master's Degree program is mandatory. Importantly, the Training Program benefits from numerous institutional resources including outstanding graduate programs in basic and clinical sciences as well as research support units such as the Liver Center and the Clinical and Translational Sciences Institute. Program faculty are strong figures in each of these units, and accordingly can guide trainees to utilize these resources to maximize the value of their postdoctoral experience. The ultimate goal of the Training Program is to provide sufficient group and individual mentorship to enable graduates to assume a faculty-level position and compete successfully for independent research funding in hepatology.

Public Health Relevance

Postdoctoral Training Program in Hepatology is designed to provide MD and PhD scientists the skills to conduct independent research relevant to the liver. The Program fills a need for basic and clinical investigators who will direct new scientific knowledge to the prevention, diagnosis and treatment of liver-related ailments. The Training Program enables faculty to provide focused research instruction to 4 trainees per year. Importantly, it also enables trainees to enroll in didactic courses and obtain an advanced degree. The ultimate goal of the Training Program is for graduates to become independent investigators, meaningful contributors to the field of hepatology, and hopefully mentors themselves. The expectation is that the trainees'research successes will translate into improved outcomes for patients suffering from liver diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Program Officer
Densmore, Christine L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
Zip Code
Burman, Blaire E; Bacchetti, Peter; Ayala, Claudia E et al. (2015) Liver inflammation is a risk factor for prediabetes in at-risk latinos with and without hepatitis C infection. Liver Int 35:101-7
Sarkar, Monika; Shvachko, Valentina A; Ready, Joanna B et al. (2014) Characteristics and management of patients with chronic hepatitis B in an integrated care setting. Dig Dis Sci 59:2100-8
Duwaerts, Caroline C; Maher, Jacquelyn J (2014) Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis. Curr Hepatol Rep 13:119-129
Burman, Blaire E; Mukhtar, Nizar A; Toy, Brian C et al. (2014) Hepatitis B management in vulnerable populations: gaps in disease monitoring and opportunities for improved care. Dig Dis Sci 59:46-56
Saxena, V; Manos, M M; Yee, H S et al. (2014) Telaprevir or boceprevir triple therapy in patients with chronic hepatitis C and varying severity of cirrhosis. Aliment Pharmacol Ther 39:1213-24
Espejel, Silvia; Eckardt, Sigrid; Harbell, Jack et al. (2014) Brief report: Parthenogenetic embryonic stem cells are an effective cell source for therapeutic liver repopulation. Stem Cells 32:1983-8
Schaub, Johanna R; Malato, Yann; Gormond, Coralie et al. (2014) Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury. Cell Rep 8:933-9
Vogt, Dorothee A; Camus, Gregory; Herker, Eva et al. (2013) Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. PLoS Pathog 9:e1003302
Lai, J C; Feng, S (2013) Too aggressive or not aggressive enough? Should a metric change center practice? Am J Transplant 13:837-8
Ho, Chanda; Kornfield, Rachel; Vittinghoff, Eric et al. (2013) Late presentation of colorectal cancer in a vulnerable population. Am J Gastroenterol 108:466-70

Showing the most recent 10 out of 28 publications