The major thrust of this Gastroenterology Research Training Program is to prepare the M.D., Ph.D, M.D./Ph.D., post-doctoral fellow, and pre-doctoral student for a career as a physician/scientist and/or independent investigator in academic Gastroenterology. There are eight multi-faceted faculty to provide prospective trainees opportunities in contemporary approaches to cellular/molecular biology, oncogenesis, signal transduction pathways, virology, immunology, stem cell biology, and biochemistry. Faculty have been recruited from the Department(s) of Medicine, and Pediatrics, and from the Brown University Pathobiology and the Molecular and Cellular Biology (MCB) Program and all operate well-funded research programs (approximately $4.8 million annual direct costs). In this context, there is a major effort to provide opportunities in translational research at the Liver Research Center and Rhode Island Hospital. In these facilities, there is access to quantitative imaging, laser capture micro-dissection, genomics and proteomics, flow cytometry, transgenic animals, and human tissue banks. The pre-doctoral trainees are recruited from the Pathobiology and MCB Graduate Program(s), and enter with majors in biology, chemistry, and cell biology. These students have a commitment to basic research on the mechanisms of human disease. The Post-doctoral trainees are recruited from several sources including the graduate programs at Brown and elsewhere as well as those having completed the minimum of two years in the Brown University/Affiliated Hospital Clinical Adult and Pediatric Gastroenterology Fellowship Program. We request two postdoctoral M.D., M.D., Ph.D. or Ph.D. trainees who will devote two or three years to basic or translational research. The research effort will be 90% for M.D. or M.D./Ph.D, and 100% for Ph.D post-doctoral Fellows. There is a request for two pre-doctoral trainees enrolled in the M.D., M.D./Ph.D. or Ph.D. graduate programs at Brown University. The trainees are instructed in the responsible conduct of research and have the opportunity to develop communication and teaching skills during the training program. Both pre- and post-doctoral trainees are required to participate in didactic courses that are enriched by weekly research seminars, journal clubs, career development workshops, and symposia. There is a strong mentoring program to develop skills in communication, grantsmanship, interdisciplinary interactions, and the implementation of basic research approaches for the diagnosis and prevention of gastrointestinal diseases. The training program is committed to offering opportunities to minority pre- and postdoctoral trainees, and there is a robust program to recruit underrepresented minority candidates. Thus the Brown University/Lifespan Affiliated Hospital Program is designed to develop academic careers in Gastroenterology and Hepatology.

Public Health Relevance

This grant is a Training Program for diseases of the gastrointestinal tract and liver. Trainees are comprised of pre-doctoral and post-doctoral candidates with the MD, PhD, or both degrees. A major emphasis of the program is to train biomedical scientist and physician scientist using state of the art investigative techniques.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK060415-09
Application #
8282881
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
2001-12-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
9
Fiscal Year
2012
Total Cost
$126,086
Indirect Cost
$9,400
Name
Rhode Island Hospital
Department
Type
DUNS #
075710996
City
Providence
State
RI
Country
United States
Zip Code
02903
Aihara, Arihiro; Huang, Chiung-Kuei; Olsen, Mark J et al. (2014) A cell-surface ?-hydroxylase is a biomarker and therapeutic target for hepatocellular carcinoma. Hepatology 60:1302-13
Tong, Ming; Longato, Lisa; Ramirez, Teresa et al. (2014) Therapeutic reversal of chronic alcohol-related steatohepatitis with the ceramide inhibitor myriocin. Int J Exp Pathol 95:49-63
Ramirez, Teresa; Longato, Lisa; Dostalek, Miroslav et al. (2013) Insulin resistance, ceramide accumulation and endoplasmic reticulum stress in experimental chronic alcohol-induced steatohepatitis. Alcohol Alcohol 48:39-52
Lizarazo, Diana; Zabala, Valerie; Tong, Ming et al. (2013) Ceramide inhibitor myriocin restores insulin/insulin growth factor signaling for liver remodeling in experimental alcohol-related steatohepatitis. J Gastroenterol Hepatol 28:1660-8
Gutelius, Danielle; Li, Jisu; Wands, Jack et al. (2011) Characterization of the pleiotropic effects of the genotype G-specific 36-nucleotide insertion in the context of other hepatitis B virus genotypes. J Virol 85:13278-89
Reilly, Emma C; Wands, Jack R; Brossay, Laurent (2010) Cytokine dependent and independent iNKT cell activation. Cytokine 51:227-31
Tessmer, Marlowe S; Fatima, Ayesha; Paget, Christophe et al. (2009) NKT cell immune responses to viral infection. Expert Opin Ther Targets 13:153-62
Laperle, Christopher M; Hamilton, Theron J; Wintermeyer, Philip et al. (2008) Low density contrast agents for x-ray phase contrast imaging: the use of ambient air for x-ray angiography of excised murine liver tissue. Phys Med Biol 53:6911-23
Lahousse, Stephanie A; Carter, Jade J; Xu, Xaolai J et al. (2006) Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells. BMC Cell Biol 7:41
Derdak, Zoltan; Fulop, Peter; Sabo, Edmond et al. (2006) Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. Carcinogenesis 27:956-61

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