This is a revised application for a renewal of the Baylor College of Medicine (BCM) Hematology Training Grant that has been successfully running for 5 years and has trained, or is training, 23 young investigators, 5 of whom are from under-represented minorities. These trainees have published a total of 65 papers directly related to their hematology training. All of our trainees have advanced substantially in their biomedical research careers, and one has become a tenured Associate Professor at BCM, and four others have junior faculty positions. The overall goal of the BCM Hematology Training Program (HTP) supported through this Grant is to foster and strengthen the research base for trainees in basic and clinical research disciplines of Hematology. Training is provided to researchers in both adult and pediatric hematology who include MD, MD/PhD and PhD trainees. The BCM HTP provides its trainees with the mentorship, research skills and experience to ultimately become productive and successful investigators in the field. The program is structured to ensure close mentorship from accomplished senior researchers at Baylor College of Medicine, and to support junior faculty to develop their own mentorship skills. The 31 faculty mentors participating in the HTP have vast teaching and training experience and share a sincere commitment to train young physician scientists in hematology research. Their expertise covers a wide range of hematology research areas including stem cell biology, hemoglobin function, iron metabolism, thrombosis, neutrophil function, myeloid cell differentiation, stem cell transplantation and cell and gene therapy. Important components of the BCM HTP are a structured training scheme involving mentored research, a didactic program, and preparation for grant writing. The PI and Co-Directors, Margaret Goodell, David Poplack, and Martha Mims have a history of close productive interaction with each other and a strong record of past trainees, assuring a close interaction and integration of basic research with clinical adult and pediatric hematology programs. Renewal of the Hematology Training Program will ensure continued training of outstanding physician-scientists in hematology at BCM.

Public Health Relevance

The goal of this program is to train young scientists and clinicians to conduct research in the area of hematology (the study of blood). There are many disorders that affect the blood, and because blood is critical to life, it is essential to keep improving our understanding of blood cells, and what goes awry with disease. Funding from this grant will help train the next generation of researchers to continue to move this crucial field forward in both basic research, and in applying our new findings to the treatment of patients.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
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Bishop, Terry Rogers
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Baylor College of Medicine
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Huang, Yung-Hsin; Su, Jianzhong; Lei, Yong et al. (2017) DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A. Genome Biol 18:176
Shum, Thomas; Omer, Bilal; Tashiro, Haruko et al. (2017) Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells. Cancer Discov 7:1238-1247
Tashiro, Haruko; Sauer, Tim; Shum, Thomas et al. (2017) Treatment of Acute Myeloid Leukemia with T Cells Expressing Chimeric Antigen Receptors Directed to C-type Lectin-like Molecule 1. Mol Ther 25:2202-2213
Ando, Kiyohiro; Parsons, Melissa J; Shah, Richa B et al. (2017) NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol 216:1795-1810
Woodard, Lauren E; Cheng, Jizhong; Welch, Richard C et al. (2017) Kidney-specific transposon-mediated gene transfer in vivo. Sci Rep 7:44904
Kruse, Robert L; Shum, Thomas; Legras, Xavier et al. (2017) In Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy. Mol Ther Methods Clin Dev 7:32-41
Liu, Kang; Lin, Fang-Tsyr; Graves, Joshua D et al. (2017) Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin. Proc Natl Acad Sci U S A 114:E3766-E3775
Del Bufalo, Francesca; Manzo, Teresa; Hoyos, Valentina et al. (2016) 3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus. Biomaterials 84:76-85
Billioud, Gaetan; Kruse, Robert L; Carrillo, Melissa et al. (2016) In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides. J Hepatol 64:781-9
Matatall, Katie A; Jeong, Mira; Chen, Siyi et al. (2016) Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation. Cell Rep 17:2584-2595

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