This is a revised application for a renewal of the Baylor College of Medicine (BCM) Hematology Training Grant that has been successfully running for 5 years and has trained, or is training, 23 young investigators, 5 of whom are from under-represented minorities. These trainees have published a total of 65 papers directly related to their hematology training. All of our trainees have advanced substantially in their biomedical research careers, and one has become a tenured Associate Professor at BCM, and four others have junior faculty positions. The overall goal of the BCM Hematology Training Program (HTP) supported through this Grant is to foster and strengthen the research base for trainees in basic and clinical research disciplines of Hematology. Training is provided to researchers in both adult and pediatric hematology who include MD, MD/PhD and PhD trainees. The BCM HTP provides its trainees with the mentorship, research skills and experience to ultimately become productive and successful investigators in the field. The program is structured to ensure close mentorship from accomplished senior researchers at Baylor College of Medicine, and to support junior faculty to develop their own mentorship skills. The 31 faculty mentors participating in the HTP have vast teaching and training experience and share a sincere commitment to train young physician scientists in hematology research. Their expertise covers a wide range of hematology research areas including stem cell biology, hemoglobin function, iron metabolism, thrombosis, neutrophil function, myeloid cell differentiation, stem cell transplantation and cell and gene therapy. Important components of the BCM HTP are a structured training scheme involving mentored research, a didactic program, and preparation for grant writing. The PI and Co-Directors, Margaret Goodell, David Poplack, and Martha Mims have a history of close productive interaction with each other and a strong record of past trainees, assuring a close interaction and integration of basic research with clinical adult and pediatric hematology programs. Renewal of the Hematology Training Program will ensure continued training of outstanding physician-scientists in hematology at BCM.
The goal of this program is to train young scientists and clinicians to conduct research in the area of hematology (the study of blood). There are many disorders that affect the blood, and because blood is critical to life, it is essential to keep improving our understanding of blood cells, and what goes awry with disease. Funding from this grant will help train the next generation of researchers to continue to move this crucial field forward in both basic research, and in applying our new findings to the treatment of patients.
|Rajagopal, Abbhirami; Braslavsky, Débora; Lu, James T et al. (2014) Exome sequencing identifies a novel homozygous mutation in the phosphate transporter SLC34A1 in hypophosphatemia and nephrocalcinosis. J Clin Endocrinol Metab 99:E2451-6|
|Ando, M; Hoyos, V; Yagyu, S et al. (2014) Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Ther 21:472-82|
|Ho, Shiuh-Rong; Mahanic, Christina S; Lee, Yu-Ju et al. (2014) RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Proc Natl Acad Sci U S A 111:E2646-55|
|Challen, Grant A; Sun, Deqiang; Mayle, Allison et al. (2014) Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell 15:350-64|
|Doherty, Joseph E; Woodard, Lauren E; Bear, Adham S et al. (2013) An adaptable system for improving transposon-based gene expression in vivo via transient transgene repression. FASEB J 27:3753-62|
|Varnado, Cornelius L; Mollan, Todd L; Birukou, Ivan et al. (2013) Development of recombinant hemoglobin-based oxygen carriers. Antioxid Redox Signal 18:2314-28|
|Flanagan, Jonathan M; Sheehan, Vivien; Linder, Heidi et al. (2013) Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia. Blood 121:3237-45|
|He, Jin; Shen, Li; Wan, Ma et al. (2013) Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol 15:373-84|
|Kettlun, Claudia; Galvan, Daniel L; George Jr, Alfred L et al. (2011) Manipulating piggyBac transposon chromosomal integration site selection in human cells. Mol Ther 19:1636-44|
|Berg, Jonathan S; Lin, Kuanyin K; Sonnet, Corinne et al. (2011) Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells. PLoS One 6:e26410|
Showing the most recent 10 out of 32 publications