The goal of this training program is to prepare predoctoral students, physicians and PhDs for biomedical research careers by providing a concentrated, in-depth research experience. Our program will provide support for three trainees per year, with a mix of one renal fellow, and one non-clinical PhD trainee, and one predoctoral student. This program is designed to foster a rigorous approach to scientific inquiry in basic science or clinical investigation. Four areas of research are emphasized: (1) renal/epithelial transport;(2) epithelial cell biology;(3) cell signaling/kidney development/renal pathophysiology/immunology;and (4) renal epidemiology/clinical research/genetics. Our training program faculty are members of the University of Pittsburgh. Together they form a well-integrated and collaborative entity dedicated to research training and investigation in nephrology, epithelial biology, renal pathophysiology, immunology, epidemiology and clinical research. Trainees will develop a research project under the close supervision of a faculty trainer and will be closely monitored by an independent advisor or thesis committee as well as by the research training executive committee. Didactic lectures, research seminars, journal clubs, formal course work, and attendance at scientific meetings will supplement this intensively structured research experience. Predoctoral graduates of this comprehensive training experience will be equipped to compete for individual training support. Postdoctoral graduates of this program will be prepared to compete for independent funding and entry-level faculty positions in academic medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK061296-09
Application #
8118931
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
2002-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
9
Fiscal Year
2011
Total Cost
$146,849
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Blobner, Brandon M; Wang, Xue-Ping; Kashlan, Ossama B (2018) Conserved cysteines in the finger domain of the epithelial Na+ channel ? and ? subunits are proximal to the dynamic finger-thumb domain interface. J Biol Chem 293:4928-4939
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Unruh, Mark L; Pankratz, V Shane; Demko, John E et al. (2017) Trial of Amiloride in Type 2 Diabetes with Proteinuria. Kidney Int Rep 2:893-904
Preston, G Michael; Brodsky, Jeffrey L (2017) The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation. Biochem J 474:445-469
Boyd-Shiwarski, Cary R; Subramanya, Arohan R (2017) The renal response to potassium stress: integrating past with present. Curr Opin Nephrol Hypertens 26:411-418

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