The goal of this training program is to prepare predoctoral students, physicians and PhDs for biomedical research careers by providing a concentrated, in-depth research experience. Our program will provide support for three trainees per year, with a mix of one renal fellow, and one non-clinical PhD trainee, and one predoctoral student. This program is designed to foster a rigorous approach to scientific inquiry in basic science or clinical investigation. Four areas of research are emphasized: (1) renal/epithelial transport;(2) epithelial cell biology;(3) cell signaling/kidney development/renal pathophysiology/immunology;and (4) renal epidemiology/clinical research/genetics. Our training program faculty are members of the University of Pittsburgh. Together they form a well-integrated and collaborative entity dedicated to research training and investigation in nephrology, epithelial biology, renal pathophysiology, immunology, epidemiology and clinical research. Trainees will develop a research project under the close supervision of a faculty trainer and will be closely monitored by an independent advisor or thesis committee as well as by the research training executive committee. Didactic lectures, research seminars, journal clubs, formal course work, and attendance at scientific meetings will supplement this intensively structured research experience. Predoctoral graduates of this comprehensive training experience will be equipped to compete for individual training support. Postdoctoral graduates of this program will be prepared to compete for independent funding and entry-level faculty positions in academic medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK061296-10
Application #
8299970
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
2002-07-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$153,569
Indirect Cost
$11,246
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Cerqueira, D├ębora M; Bodnar, Andrew J; Phua, Yu Leng et al. (2017) Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development. FASEB J 31:3540-3554
Preston, G Michael; Brodsky, Jeffrey L (2017) The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation. Biochem J 474:445-469
Unruh, Mark L; Pankratz, V Shane; Demko, John E et al. (2017) Trial of Amiloride in Type 2 Diabetes with Proteinuria. Kidney Int Rep 2:893-904
Guerriero, Christopher J; Reutter, Karl-Richard; Augustine, Andrew A et al. (2017) Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates. Mol Biol Cell 28:2076-2090
Buck, Teresa M; Jordahl, Alexa S; Yates, Megan E et al. (2017) Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein. Biochem J 474:357-376
Ray, Evan C; Boyd-Shiwarski, Cary R; Kleyman, Thomas R (2017) Why Diuretics Fail Failing Hearts. J Am Soc Nephrol 28:3137-3138
Long, Kimberly R; Shipman, Katherine E; Rbaibi, Youssef et al. (2017) Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway. Mol Biol Cell 28:2508-2517
Rahaman, Mizanur M; Nguyen, Anh T; Miller, Megan P et al. (2017) Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling. Circ Res 121:137-148
Boyd-Shiwarski, Cary R; Shiwarski, Daniel J; Roy, Ankita et al. (2017) Potassium-Regulated Distal Tubule WNK Bodies are Kidney-Specific WNK1 Dependent. Mol Biol Cell :
Tan, Roderick J; Chartoumpekis, Dionysios V; Rush, Brittney M et al. (2016) Keap1 hypomorphism protects against ischemic and obstructive kidney disease. Sci Rep 6:36185

Showing the most recent 10 out of 83 publications