The goal of this training program is to prepare predoctoral students, physicians and PhDs for biomedical research careers by providing a concentrated, in-depth research experience. Our program will provide support for three trainees per year, with a mix of one renal fellow, and one non-clinical PhD trainee, and one predoctoral student. This program is designed to foster a rigorous approach to scientific inquiry in basic science or clinical investigation. Four areas of research are emphasized: (1) renal/epithelial transport;(2) epithelial cell biology;(3) cell signaling/kidney development/renal pathophysiology/immunology;and (4) renal epidemiology/clinical research/genetics. Our training program faculty are members of the University of Pittsburgh. Together they form a well-integrated and collaborative entity dedicated to research training and investigation in nephrology, epithelial biology, renal pathophysiology, immunology, epidemiology and clinical research. Trainees will develop a research project under the close supervision of a faculty trainer and will be closely monitored by an independent advisory or thesis committee as well as by the research training executive committee. Didactic lectures, research seminars, journal clubs, formal course work, and attendance at scientific meetings will supplement this intensively structured research experience. Predoctoral graduates of this comprehensive training experience will be equipped to compete for individual training support. Postdoctoral graduates of this program will be prepared to compete for independent funding and entry-level faculty positions in academic medicine.

Public Health Relevance

There have been tremendous advances in biomedical sciences over the past several decades that should enhance our ability to diagnose, treat and prevention of kidney diseases. However, we still face challenges in advancing our understanding of kidney physiology and of diseases of the kidney, as well as our ability to translate these remarkable basic science discoveries into new drugs and treatments for patients. The main objective of our training program is to provide an intensive and structured research experience for both physicians and non-physician trainees in order to foster the development of the skills needed to pursue a successful career in the areas of investigative nephrology and epithelial biology.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
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Rys-Sikora, Krystyna E
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University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
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Belayev, Linda Y; Mor, Maria K; Sevick, Mary Ann et al. (2015) Longitudinal associations of depressive symptoms and pain with quality of life in patients receiving chronic hemodialysis. Hemodial Int 19:216-24
Szalinski, Christina M; Labilloy, Anatália; Bruns, Jennifer R et al. (2014) VAMP7 modulates ciliary biogenesis in kidney cells. PLoS One 9:e86425
Adelman, Joshua L; Sheng, Ying; Choe, Seungho et al. (2014) Structural determinants of water permeation through the sodium-galactose transporter vSGLT. Biophys J 106:1280-9
Belayev, Linda Y; Palevsky, Paul M (2014) The link between acute kidney injury and chronic kidney disease. Curr Opin Nephrol Hypertens 23:149-54
Mukherjee, Anindit; Mueller, Gunhild M; Kinlough, Carol L et al. (2014) Cysteine palmitoylation of the ? subunit has a dominant role in modulating activity of the epithelial sodium channel. J Biol Chem 289:14351-9
Choudhary, Om P; Paz, Aviv; Adelman, Joshua L et al. (2014) Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1. Nat Struct Mol Biol 21:626-32
Tan, Roderick J; Liu, Youhua (2013) Macrophage-derived TGF-* in renal fibrosis: not a macro-impact after all. Am J Physiol Renal Physiol 305:F821-2
Adelman, Joshua L; Grabe, Michael (2013) Simulating rare events using a weighted ensemble-based string method. J Chem Phys 138:044105
Wang, Zhijian; Subramanya, Arohan R; Satlin, Lisa M et al. (2013) Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase. Am J Physiol Cell Physiol 305:C846-53
Szalinski, Christina M; Guerriero, Christopher J; Ruiz, Wily G et al. (2013) PIP5KI? selectively modulates apical endocytosis in polarized renal epithelial cells. PLoS One 8:e53790

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