The interdisciplinary program in Molecular and Biochemical Nutrition provides training for pre-doctoral candidates in the concepts, techniques and implementation of molecular and biochemical metabolic studies. This training program aims to cultivate independent and original thinking, and to provide for development of scholarship and skills in research, teaching and professional service. The program is designed to attract and nurture qualified candidates from all sections of society, and emphasizes metabolism of nutrients and phytochemicals, metabolic regulation, and mechanisms of nutrient and phytochemical actions in humans and mammals that serve as human models. Program faculty are well suited for this training mission through their multidisciplinary expertise in the techniques of biochemistry, molecular biology, analytical biochemistry, cell biology, clinical studies, and genomics;and through their research programs that study metabolic problems focused on human metabolism, metabolism-related diseases, and mechanisms of nutrient and phytochemical action. The interdepartmental, interdisciplinary training program in Molecular and Biochemical Nutrition is distinctive on the Berkeley campus: it is the only program devoted to molecular metabolic biology. Thus, the nature of the program, the faculty, the resources, and the environment all offer fertile and unique opportunities for sophisticated interdisciplinary training in metabolic studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK061918-10
Application #
8132898
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
2002-09-01
Project End
2012-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
10
Fiscal Year
2011
Total Cost
$176,060
Indirect Cost
Name
University of California Berkeley
Department
Nutrition
Type
Schools of Earth Sciences/Natur
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Napoli, Joseph L (2017) Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases. Pharmacol Ther 173:19-33
Ikon, Nikita; Shearer, Jennifer; Liu, Jianfang et al. (2017) A facile method for isolation of recombinant human apolipoprotein A-I from E. coli. Protein Expr Purif 134:18-24
Ikon, Nikita; Ryan, Robert O (2017) Cardiolipin and mitochondrial cristae organization. Biochim Biophys Acta 1859:1156-1163
Nguyen, Truc B; Louie, Sharon M; Daniele, Joseph R et al. (2017) DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Dev Cell 42:9-21.e5
Ikon, Nikita; Ryan, Robert O (2017) Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy. Lipids 52:99-108
Counihan, Jessica L; Ford, Breanna; Nomura, Daniel K (2016) Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms. Curr Opin Chem Biol 30:68-76
Jha, Amit K; Tharp, Kevin M; Browne, Shane et al. (2016) Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials 89:136-47
Thompson, Airlia C S; Bruss, Matthew D; Price, John C et al. (2016) Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice. Aging Cell 15:118-27
Khalifeh-Soltani, Amin; Ha, Arnold; Podolsky, Michael J et al. (2016) ?8?1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. Elife 5:
Ikon, Nikita; Ryan, Robert O (2016) On the origin of 3-methylglutaconic acid in disorders of mitochondrial energy metabolism. J Inherit Metab Dis 39:749-756

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