The program in Molecular and Biochemical Nutrition at the University of California, Berkeley provides interdisciplinary training for pre-doctoral candidates in the concepts, techniques, and implementation in the area of modern biochemical nutrition, which we refer to as Metabolic Biology. This training program aims to cultivate independent and original thinking, and to provide for development of scholarship and skills in research, teaching and professional service. The program has been designed and seeks to attract and nurture qualified students from all sections of society. The program intends to qualify graduates to create, direct and pursue independent investigation in academia, but also recognizes that graduates are prepared to contribute to health-related issues by serving in government and industry. The program emphasizes lab and pre-clinical investigations into metabolic regulation, and mechanisms of nutrient and xenobiotic metabolism and actions in humans, and mammals that serve as models for human physiological processes and diseases. Program faculty are well suited to support this training mission through their multidisciplinary expertise in analytical chemistry and biochemistry, biochemistry, molecular biology, cell biology, clinical studies, and genomics. The training mission is augmented through the well-funded research programs of participating faculty, who study metabolic regulation focused on human nutrition, nutrition-related diseases, mechanisms of nutrient action, and toxicology (as it applies to food-borne toxicants or chemical intentionally ingested by humans, such as ethanol). Program faculty have Ph.D. degrees in chemistry, nutrition, biochemistry, molecular biology, and several have earned MD or dual MD/Ph.D. degrees. These factors foster an interdisciplinary environment and provide opportunities for collaboration to focus different perspectives and skills on metabolic health-related issues. In addition, the program is expanding its expertise from LC/MS/MS and GC/MS, as applied to quantification of select metabolites and deuterium isotope studies, to proteomics and metabolomics through the purchase of two new mass spectrometers and hiring faculty and support personnel. The interdisciplinary training program in Molecular and Biochemical Nutrition is distinctive on the Berkeley campus: it is the only program devoted to Metabolic Biology, i.e. metabolic biochemistry, modern experimental nutrition, and food-based toxicology in higher vertebrates. Thus, the goals and nature of the program, the faculty, the resources, and the environment provide a unique opportunity on the Berkeley campus for interdisciplinary training in metabolic studies pertaining to common human diseases and disease risk.

Public Health Relevance

As our population increasingly incurs diseases related to aging, poor nutrition, and literally sickening lifestyles, there is growing need to train scientits who meld the entire tool chest of biological techniques to study the metabolism and function of nutrients, phytochemicals, and diet-borne toxicants, as they relate to human disease risk. The mission of the program in Molecular and Biochemical Nutrition at the University of California, Berkeley is training scientists capable of generating sophisticated insight into mechanisms of disease and disease risk related to diet and regulation of metabolism.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK061918-13
Application #
8731862
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
2002-09-01
Project End
2017-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
13
Fiscal Year
2014
Total Cost
$188,725
Indirect Cost
$11,070
Name
University of California Berkeley
Department
Nutrition
Type
Schools of Earth Sciences/Natur
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Thompson, Airlia C S; Bruss, Matthew D; Price, John C et al. (2016) Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice. Aging Cell 15:118-27
Counihan, Jessica L; Ford, Breanna; Nomura, Daniel K (2016) Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms. Curr Opin Chem Biol 30:68-76
Li, Lei; Che, Li; Tharp, Kevin M et al. (2016) Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans. Hepatology 63:1900-13
Jha, Amit K; Tharp, Kevin M; Browne, Shane et al. (2016) Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials 89:136-47
Tharp, Kevin M; Khalifeh-Soltani, Amin; Park, Hyo Min et al. (2016) Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis. Am J Physiol Gastrointest Liver Physiol 310:G855-64
Khalifeh-Soltani, Amin; Ha, Arnold; Podolsky, Michael J et al. (2016) α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. Elife 5:
Ikon, Nikita; Ryan, Robert O (2016) On the origin of 3-methylglutaconic acid in disorders of mitochondrial energy metabolism. J Inherit Metab Dis 39:749-56
Tharp, Kevin M; Stahl, Andreas (2015) Bioengineering Beige Adipose Tissue Therapeutics. Front Endocrinol (Lausanne) 6:164
Piano, Valentina; Benjamin, Daniel I; Valente, Sergio et al. (2015) Discovery of Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anti-Cancer Agents. ACS Chem Biol 10:2589-97
Dempersmier, Jon; Sambeat, Audrey; Gulyaeva, Olga et al. (2015) Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. Mol Cell 57:235-46

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