Training young scientists in nephrology is especially needed because of the prevalence of CKD with its devastating complications (e.g., cardiovascular disease (CVD), inflammation, malnutrition, etc.). The nephrologist's special knowledge about kidney function and CKD complications can lead to substantial advances in preventing and treating these complications (e.g, how uremia influences vascular complications, protein metabolism, etc.). Our goal is to provide superb scientific training so bright, young physicians will develop the skills needed to become competitive investigators. To accomplish this, we have recruited 3 NEH-funded mentors to provide training and have detailed didactic opportunities for those interested in clinical investigations. We continue to take advantage of the rich scientific environment of Baylor. Our overall rationale is that interdisciplinary research training based on state-of-the-art techniques in an environment emphasizing basic and translational research will stimulate fellows to investigate how and why kidney disease and its complications develop. Our interdisciplinary Training Program includes 2 (preferably 3 years) of research training working directly with preceptors who are established basic or clinical investigators and have a record of training scientists and NIH funding plus a history of interactions with Nephrology faculty and each other. Research areas include mechanisms causing CVD (lipid metabolism, diabetic complications, arteriosclerosis, the cell biology of heart fibrosis and neointima development in vein grafts). The contributions of cytokine and signaling pathways to inflammation, kidney damage and mechanisms of muscle wasting. Each year we plan for 3 MD/MD-PhD trainees, who will train for a minimum of 2 years with mentors who have extensive experience in basic or clinical sciences. Training will include a strong didactic program to ensure a background sufficient to understand rigorous experimental design and dedication to scientific principles, biostatistics and ethics. The interdisciplinary plan integrates different scientific disciplines and takes advantage of the intellectual opportunities and core facilities of Baylor. Relevance: millions of Americans have kidney disease and more are at risk of developing kidney disease and its complications because of the growing prevalence of diabetes. Bright young nephrologist-scientists trained in research must be trained so they can advance the treatment of patients with CKD and its complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK062706-10
Application #
8513313
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
2003-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$181,341
Indirect Cost
$14,232
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Huang, Luping; Lou, Yahuan; Ju, Huiming et al. (2015) Severe Nephrotoxic Nephritis following Conditional and Kidney-Specific Knockdown of Stanniocalcin-1. PLoS One 10:e0138440
Pan, Jenny Szu-Chin; Huang, Luping; Belousova, Tatiana et al. (2015) Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway. J Am Soc Nephrol 26:364-78
Yan, Jingyin; Zhang, Zhengmao; Yang, Jun et al. (2015) JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis. J Am Soc Nephrol 26:3060-71
Huang, Luping; Zhang, Lin; Ju, Huiming et al. (2015) Stanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury. Sci Rep 5:18117
Xia, Yunfeng; Yan, Jingyin; Jin, Xiaogao et al. (2014) The chemokine receptor CXCR6 contributes to recruitment of bone marrow-derived fibroblast precursors in renal fibrosis. Kidney Int 86:327-37
Xia, Yunfeng; Jin, Xiaogao; Yan, Jingyin et al. (2014) CXCR6 plays a critical role in angiotensin II-induced renal injury and fibrosis. Arterioscler Thromb Vasc Biol 34:1422-8
Huang, Luping; Belousova, Tatiana; Pan, Jenny Szu-Chin et al. (2014) AKI after conditional and kidney-specific knockdown of stanniocalcin-1. J Am Soc Nephrol 25:2303-15
Dong, Yanjun; Pan, Jenny S; Zhang, Liping (2013) Myostatin suppression of Akirin1 mediates glucocorticoid-induced satellite cell dysfunction. PLoS One 8:e58554
Doherty, Joseph E; Woodard, Lauren E; Bear, Adham S et al. (2013) An adaptable system for improving transposon-based gene expression in vivo via transient transgene repression. FASEB J 27:3753-62
Thomas, Sandhya S; Dong, Yanjun; Zhang, Liping et al. (2013) Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease. Kidney Int 84:308-16

Showing the most recent 10 out of 22 publications