The purpose of our Training Program in GI Epidemiology is to develop academic gastroenterologists trained in the design and execution of clinical research. This is the second competitive renewal application of our uniquely-focused program, which is one of only three GI Epidemiology Training Programs in the US. With this training, these GI fellows become junior faculty who successfully compete for external funding. Since inception in 2002, 10 trainees have completed this program: 80% (8/10) accepted tenure-track positions at academic medical centers and 70% successfully applied for foundation or federal career development awards. (Our most recent trainee will be interviewing for a tenure-track position.) Support is requested for 2 post-doctoral trainees (i.e., gastroenterology fellows) with each post-doctoral trainee completing two years of training. The goals of the Training Program in GI Epidemiology are: (a) Completion of a MSc degree focused on the design and execution of clinical research;(b) Completion of a focused GI Epidemiology seminar series and a comprehensive clinical epidemiology/health care policy seminar series;(c) Successful design, execution, and publication of multiple clinical research projects under the guidance of a team of mentors, including methodology experts (e.g., epidemiologists) and content experts (e.g., gastroenterologists);and, (d) Preparation of a career development award grant application to provide transitional funding and facilitate an independent career in academic medicine and research. Each trainee focuses on a specific issue (e.g., impact of IL-28b polymorphism on treatment of HCV) and completes three projects: (a) a meta-analysis;(b) a retrospective database study;and, (c) design of a prospective trial. These projects provide the foundation and preliminary data for the career development award grant application. The environment at the University of Michigan has vast resources from multiple centers and research institutes. These resources include the Robert Wood Johnson Foundation Clinical Scholars Program, Ann Arbor VA Center for Clinical Management Research (VA Center of Excellence for Health Services Research &Development), and the Michigan Institute of Clinical &Health Research (MICHR). Our multi-disciplinary faculty includes expert biostatisticians, epidemiologists, and outcomes researchers from the Divisions of General Internal Medicine and Gastroenterology. Most faculty are federally funded for their on-going research, and these faculty offer a broad spectrum of research expertise with multiple levels of established collaboration and many years of experience mentoring trainees.

Public Health Relevance

Gastroenterologists trained to perform translational and clinical research are needed to translate new discoveries in basic science into better patient care. Since this program began in 2002, our trainees have fulfilled this need: 80% of our trainees have transitioned to become gastroenterologists at academic medical centers and these physicians have successfully applied for multiple research grants while producing numerous publications about their work. Therefore, we believe that our track record demonstrates the success of our program, which is supported by superb faculty and tremendous resources at the University of Michigan. Support is requested for 2 postdoctoral trainees per year who are selected from our gastroenterology fellowship program.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Densmore, Christine L
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University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
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Shah, Eric D; Allen, John I (2018) How to Become a Physician Executive: From Fellowship to Leadership. Gastroenterology 154:784-787
Thomson, Mary J; Tapper, Elliot B; Lok, Anna S F (2018) Dos and Don'ts in the Management of Cirrhosis: A View from the 21st Century. Am J Gastroenterol 113:927-931
Mellinger, Jessica L; Volk, Michael L (2018) Transplantation for Alcohol-related Liver Disease: Is It Fair? Alcohol Alcohol 53:173-177
Shah, Eric D; Kim, Hyungjin Myra; Schoenfeld, Philip (2018) Efficacy and Tolerability of Guanylate Cyclase-C Agonists for Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation: A Systematic Review and Meta-Analysis. Am J Gastroenterol 113:329-338
Thomson, Mary; Tapper, Elliot B (2018) Towards patient-centred and cost-effective care for patients with cirrhosis and ascites. Lancet Gastroenterol Hepatol 3:75-76
Maratt, Jennifer K; Calderwood, Audrey H; Saini, Sameer D (2018) When and How to Stop Surveillance Colonoscopy in Older Adults: Five Rules of Thumb for Practitioners. Am J Gastroenterol 113:5-7
Maratt, Jennifer K; Menees, Stacy B; Piper, Marc S et al. (2018) Patients Are Willing to Repeat Colonoscopy at a Short Interval When Bowel Preparation Quality Is Suboptimal. Clin Gastroenterol Hepatol 16:776-777
Thomson, Mary J; Lok, Anna S; Tapper, Elliot B (2018) Optimizing medication management for patients with cirrhosis: Evidence-based strategies and their outcomes. Liver Int 38:1882-1890
Konerman, Monica A; Thomson, Mary; Gray, Kristen et al. (2017) Impact of an electronic health record alert in primary care on increasing hepatitis c screening and curative treatment for baby boomers. Hepatology 66:1805-1813
Konerman, Monica A; Lu, Dongxia; Zhang, Yiwei et al. (2017) Assessing risk of fibrosis progression and liver-related clinical outcomes among patients with both early stage and advanced chronic hepatitis C. PLoS One 12:e0187344

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