Urologic disease causes significant morbidity and lost quality of life to millions in the U.S., and these problems will only grow more burdensome to the healthcare system in our aging population. At the same time, advances in biology and medicine offer new opportunities to understand mechanisms of urologic disease and develop novel therapies for patients - promise that can only be realized through research. The goal of this training program is to cultivate and maintain the ranks of future leaders in urological research. Building upon a history of successfully training leaders in urology, the proposed training program offers opportunities to promising, young basic and clinician scientists to engage in urologic research by supporting predoctoral and postdoctoral fellows in a structured training program. Fellows will be selected from among highly qualified predoctoral candidates identified within Northwestern Ph.D. programs and solicited postdoctoral candidates, always working to attract and support candidates that fulfill Northwestern's goal of enhancing diversity. Fellows wil select from a distinguished, interdisciplinary panel of successful preceptors and enter into a rigorous training program that complements advanced scientific training with careful instruction in research integrity and fostering individual development. Two predoctoral and two postdoctoral candidates will be selected and appointed for a two year training period each year of the award. Committees internal and external to the program will oversee trainee selection and progress, thus insuring fellows take full advantage of the rich, supportive environment and emerge as leaders in urology.

Public Health Relevance

Urologic disease impacts millions of patients with significant losses in quality of life. This training program will build on our history at Northwestern of successfully training leaders in urology by providing fellowships to support the next generation of leaders in urologic sciences

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK062716-12
Application #
9264521
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK-D)
Program Officer
Rankin, Tracy L
Project Start
2003-06-01
Project End
2021-04-30
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
12
Fiscal Year
2017
Total Cost
$225,475
Indirect Cost
$14,491
Name
Northwestern University at Chicago
Department
Urology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Plebanek, Michael P; Bhaumik, Debayan; Bryce, Paul J et al. (2018) Scavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells. Mol Cancer Ther 17:686-697
Plebanek, Michael P; Angeloni, Nicholas L; Vinokour, Elena et al. (2017) Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche. Nat Commun 8:1319
Angeloni, Nicholas L; McMahon, Kaylin M; Swaminathan, Suchitra et al. (2016) Pathways for Modulating Exosome Lipids Identified By High-Density Lipoprotein-Like Nanoparticle Binding to Scavenger Receptor Type B-1. Sci Rep 6:22915
Rudick, Charles N; Jiang, Mingchen; Yaggie, Ryan E et al. (2012) O-antigen modulates infection-induced pain states. PLoS One 7:e41273
Rudick, Charles N; Pavlov, Vladimir I; Chen, Michael C et al. (2012) Gender specific pelvic pain severity in neurogenic cystitis. J Urol 187:715-24
Done, Joseph D; Rudick, Charles N; Quick, Marsha L et al. (2012) Role of mast cells in male chronic pelvic pain. J Urol 187:1473-82
Biyashev, Dauren; Veliceasa, Dorina; Topczewski, Jacek et al. (2012) miR-27b controls venous specification and tip cell fate. Blood 119:2679-87
Rudick, Charles N; Billips, Benjamin K; Pavlov, Vladimir I et al. (2010) Host-pathogen interactions mediating pain of urinary tract infection. J Infect Dis 201:1240-9
Aurora, Arin B; Aurora, Aryn B; Biyashev, Dauren et al. (2010) NF-kappaB balances vascular regression and angiogenesis via chromatin remodeling and NFAT displacement. Blood 116:475-84
Rudick, Charles N; Schaeffer, Anthony J; Klumpp, David J (2009) Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis. BMC Urol 9:16

Showing the most recent 10 out of 19 publications