This application is a proposal for a Fellowship training program in pediatric endocrinology, designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC), and the Children's Hospital Colorado (CHC) at the University of Colorado School of Medicine. The proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particularly those trained and experienced in diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economics viewpoint 3) Current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out basic and translational research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center and CHC have an extensive and a proven record in research training of young investigators. A strong clinical endocrinology program at Children's Hospital, in addition to a research base in type 2 diabetes, will provide a well-rounded pediatric endocrinology training program. The BDC, CHC and the wider Anschutz Medical Campus (AMC) have a well-established network of investigators working in the epidemiology, immunobiology, genetics, and molecular biology of type 1 and type 2 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists and encourage them in a career as diabetes investigators. Areas of research focus within the Barbara Davis Center include islet cell physiology, genetics, molecular biology, immunology, the autoimmunity, prediction and prevention of type 1 diabetes, and the epidemiology, prevention and improved, novel treatment of type 1 and type 2 diabetes. These areas of research are urgently needed and have been identified as important to the national public health to address the epidemic of diabetes in the US. This application is enhanced by the NIH supported Colorado Clinical and Translational Research Institute (CCTSI), Pediatric and Adult Clinical Translational Research Centers, as well as a strong Masters of Science in Public Health Program in the Colorado School of Public Health (CSPH) and a Masters in Clinical Science within the CCTSI. This application has the support of the Departments of Pediatrics, Medicine, The CSPH, the CCTSI and Children's Hospital Colorado. The ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology, as well as human medical genetics and molecular genetics through the CCTSI, the BDC, the Program in Human Genetics and the CSPH, combined with a strong mentoring faculty at the BDC, CHC and the wider AMC will allow us to provide the training required to develop pediatric endocrinologists as the physician scientists needed in academic pediatric endocrinology to be the leaders of tomorrow.

Public Health Relevance

Our NIDDK T32 Training Program Developing Pediatric Endocrinologists for the Future will be conducted at the Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine and Children's Hospital Colorado, Anschutz Medical Campus. Our PRINCIPAL OBJECTIVE is to develop Pediatric Endocrinologists who are well grounded in basic and/or translational science research skills required for advancing the field of knowledge in type 1 and type 2 diabetes and are educated in collaborative and integrated approaches for translating basic discoveries in diabetes into opportunities for advancing clinical research and care. Our OVERALL GOAL is that after their training, our trainees will have acquired the professional skills to become clinician scientists beginning productive academic careers as junior faculty investigators who will have the leadership capacity to make significant impacts in the field of type 1 and type 2 diabetes in children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK063687-11A1
Application #
8665041
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
2002-09-30
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Aurora
State
CO
Country
United States
Zip Code
80045
Bjornstad, Petter; Škrtić, Marko; Lytvyn, Yuliya et al. (2016) The Gomez' equations and renal hemodynamic function in kidney disease research. Am J Physiol Renal Physiol :ajprenal.00415.2016
Bjornstad, Petter; Truong, Uyen; Dorosz, Jennifer L et al. (2016) Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc 5:e002804
Cree-Green, Melanie; Gupta, Abhinav; Coe, Gregory V et al. (2016) Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction. J Diabetes Complications :
Bjornstad, Petter; Johnson, Richard J; Snell-Bergeon, Janet K et al. (2016) Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank. J Diabetes Complications :
Shah, Pratik; Bjornstad, Petter; Johnson, Richard J (2016) Hyperuricemia as a potential risk factor for type 2 diabetes and diabetic nephropathy. J Bras Nefrol 38:386-387
Chan, Christine L; Pyle, Laura; Kelsey, Megan M et al. (2016) Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes. Pediatr Diabetes :
Davis, S; Lahlou, N; Bardsley, M et al. (2016) Gonadal function is associated with cardiometabolic health in pre-pubertal boys with Klinefelter syndrome. Andrology :
Shumer, Daniel E; Nokoff, Natalie J; Spack, Norman P (2016) Advances in the Care of Transgender Children and Adolescents. Adv Pediatr 63:79-102
Cree-Green, Melanie; Bergman, Bryan C; Coe, Gregory V et al. (2016) Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance. Obesity (Silver Spring) 24:2399-2406
Davis, Shanlee M; Cox-Martin, Matthew; Bardsley, Martha et al. (2016) Effects of Oxandrolone on Cardiometabolic Health in Boys with Klinefelter syndrome: A Randomized Controlled Trial. J Clin Endocrinol Metab :jc20162904

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