To address the severe shortage of academic pediatric endocrinologists, this Training Program will take advantage of the important new opportunities for advancing diabetes and endocrine research in children provided by such recent scientific advances as the Human Genome Project, islet transplantation and biomechanical and bio-engineered islets, and the NIH roadmap transformation of GCRC programs for patient- oriented research into Clinical Translational Science Awards. The Program will support Trainees during up to 2 years of research training at the fellowship level. The Training faculty includes 29 scientific mentors from the Children's Hospital and the Perelman School of Medicine at the University of Pennsylvania who have outstanding credentials and active funded research programs and well-established training records. These mentors will supervise Trainees in basic laboratory research and/or patient-oriented and translational research projects related to diabetes and endocrine disorders in children. Research opportunities will include several areas of basic research (Cell Function, Hormone Action, Mechanisms of Disease, Endocrine Physiology, and Transcriptional Regulation). Patient-oriented research opportunities will include Translational Research, Disease Mechanisms, Pathophysiology, Diabetes Complications, Genetics, Clinical Trials, Metabolic Syndrome, Nutrition, and Epidemiology. The Program includes multiple interactions for Trainees with basic and clinical research and training in all aspects of research, including biostatistics, bioethics, molecular biology, etc. The Program is strongly supported by access to a superb range of institutional resources at Children's Hospital and University of Pennsylvania, including the CTSA and the University of Pennsylvania DERC. The request is made to support 3 fellow slots and 2 student slots in this Program each year. The long-term goal of this T32 Training Program renewal is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative and scientifically rigorous patient- oriented and laboratory-based research in diabetes and endocrine disorders of children.
The long-term goal of this T32 Training Program renewal is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative and scientifically rigorous patient-oriented and laboratory-based research in diabetes and endocrine disorders of children. This will address a major public health need which is the critical shortage of academic pediatric endocrinologists in diabetes and endocrinology research. The Program will support 3 Fellow Trainees per year for up to 2 years of mentored research training at the fellowship level working with NIH funded Training faculty from the Children's Hospital and the Perelman School of Medicine at University of Pennsylvania, as well as 2 postdoctoral summer interns/year.
| Gannon, Anthony W; Langer, Jill E; Bellah, Richard et al. (2018) Diagnostic Accuracy of Ultrasound With Color Flow Doppler in Children With Thyroid Nodules. J Clin Endocrinol Metab 103:1958-1965 |
| McCormack, Shana E; Cousminer, Diana L; Chesi, Alessandra et al. (2017) Association Between Linear Growth and Bone Accrual in a Diverse Cohort of Children and Adolescents. JAMA Pediatr 171:e171769 |
| Leichner, Theresa M; Satake, Atsushi; Harrison, Victor Sanoe et al. (2017) Skin-derived TSLP systemically expands regulatory T cells. J Autoimmun 79:39-52 |
| Pinney, Sara E; Mesaros, Clementina A; Snyder, Nathaniel W et al. (2017) Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants. Reprod Toxicol 67:1-9 |
| Hanley, Patrick; Sutter, Jennifer A; Goodman, Noah G et al. (2017) Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes. Clin Immunol 183:336-343 |
| Harrison, V Sanoe; Rustico, Stacy; Palladino, Andrew A et al. (2017) Glargine co-administration with intravenous insulin in pediatric diabetic ketoacidosis is safe and facilitates transition to a subcutaneous regimen. Pediatr Diabetes 18:742-748 |
| Harrison, Victor S; Oatman, Oliver; Kerrigan, John F (2017) Hypothalamic hamartoma with epilepsy: Review of endocrine comorbidity. Epilepsia 58 Suppl 2:50-59 |
| McCormack, Shana E; Chesi, Alessandra; Mitchell, Jonathan A et al. (2017) Relative Skeletal Maturation and Population Ancestry in Nonobese Children and Adolescents. J Bone Miner Res 32:115-124 |
| Kelley, Jennifer C; Crabtree, Nicola; Zemel, Babette S (2017) Bone Density in the Obese Child: Clinical Considerations and Diagnostic Challenges. Calcif Tissue Int 100:514-527 |
| Roizen, Jeffrey D; Danzig, Jennifer; Groleau, Veronique et al. (2016) Resting Energy Expenditure Is Decreased in Pseudohypoparathyroidism Type 1A. J Clin Endocrinol Metab 101:880-8 |
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