The goal of the training program is to prepare physicians and pre- and post- doctoral trainees for biomedical research careers in digestive diseases by providing concentrated, structured and well-mentored research training. The program will provide training to 4 postdoctoral fellows and 1 predoctoral student with an overall mix of 2-3 physician-scientists and 1-2 translational/basic research postdoctoral trainees per year. The program offers opportunities in four basic Research Training Units that reflect the clinical Centers of Excellence in the Digestive Disorder Center leveraged against the basic science strengths of the University of Pittsburgh. The training units include: 1) Inflammatory Bowel Diseases, 2) Neurogastroenterology and Motility, 3) Pancreas, Biliary and Liver Diseases, and 4) Gl Cancers. Transecting these units are scientific disciplines of genetics, immunology, neuroscience, molecular and cellular biology, and epidemiology. The training faculty are [sic] all members of the University of Pittsburgh and characterized by R01 funding, excellent training records, productive collaborations and a dedication to understanding the pathophysiology of digestive diseases. Together they form a close and well-integrated entity dedicated to research training and investigations in gastroenterology, hepatology, pancreatic and nutritional disorders, with research foci ranging from small molecules to global human populations. Trainees will develop a research project under the close supervision of a faculty trainer and will be monitored by an advisory group or thesis committee as well as by a research training executive committee. Didactic lectures, research seminars, journal clubs, formal course work and attendance at scientific meetings will supplement this intensively structured research experience. Predoctoral graduates of this training program will be equipped to compete for individual training support. Postdoctoral graduates will be prepared to compete for independent funding and entry level faculty positions in academic medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK063922-10
Application #
8306333
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
2003-07-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$340,399
Indirect Cost
$21,123
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Chao, David T; Shah, Nilesh H; Zeh 3rd, Herbert J et al. (2016) Increased Serum Insulin Exposure Does Not Affect Age or Stage of Pancreatic Adenocarcinoma Diagnosis in Patients With Diabetes Mellitus. Pancreas 45:228-33
Dum, Richard P; Levinthal, David J; Strick, Peter L (2016) Motor, cognitive, and affective areas of the cerebral cortex influence the adrenal medulla. Proc Natl Acad Sci U S A 113:9922-7
Anderson, Alyce J M; Click, Benjamin; Ramos-Rivers, Claudia et al. (2016) Development of an Inflammatory Bowel Disease Research Registry Derived from Observational Electronic Health Record Data for Comprehensive Clinical Phenotyping. Dig Dis Sci 61:3236-3245
Koutroubakis, Ioannis E; Ramos-Rivers, Claudia; Regueiro, Miguel et al. (2016) Five-Year Period Prevalence and Characteristics of Anemia in a Large US Inflammatory Bowel Disease Cohort. J Clin Gastroenterol 50:638-43
Click, Benjamin; Ramos Rivers, Claudia; Koutroubakis, Ioannis E et al. (2016) Demographic and Clinical Predictors of High Healthcare Use in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis 22:1442-9
Reeves, Valerie L; Trybula, Joy S; Wills, Rachel C et al. (2015) Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity. Obesity (Silver Spring) 23:2371-6
Click, Benjamin; Vargas, Eric J; Anderson, Alyce M et al. (2015) Silent Crohn's Disease: Asymptomatic Patients with Elevated C-reactive Protein Are at Risk for Subsequent Hospitalization. Inflamm Bowel Dis 21:2254-61
Seminerio, Jennifer L; Koutroubakis, Ioannis E; Ramos-Rivers, Claudia et al. (2015) Impact of Obesity on the Management and Clinical Course of Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis 21:2857-63
Rogal, Shari S; Bielefeldt, Klaus; Wasan, Ajay D et al. (2015) Inflammation, psychiatric symptoms, and opioid use are associated with pain and disability in patients with cirrhosis. Clin Gastroenterol Hepatol 13:1009-16
Shah, Nilesh H; Hipwell, Alison E; Stepp, Stephanie D et al. (2015) Measures of discrimination for latent group-based trajectory models. J Appl Stat 42:1-11

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