The goal of the training program is to prepare physicians and pre- and post- doctoral trainees for biomedical research careers in digestive diseases by providing concentrated, structured and well-mentored research training. The program will provide training to 4 postdoctoral fellows and 1 predoctoral student with an overall mix of 2-3 physician-scientists and 1-2 translational/basic research postdoctoral trainees per year. The program offers opportunities in four basic Research Training Units that reflect the clinical Centers of Excellence in the Digestive Disorder Center leveraged against the basic science strengths of the University of Pittsburgh. The training units include: 1) Inflammatory Bowel Diseases, 2) Neurogastroenterology and Motility, 3) Pancreas, Biliary and Liver Diseases, and 4) Gl Cancers. Transecting these units are scientific disciplines of genetics, immunology, neuroscience, molecular and cellular biology, and epidemiology. The training faculty are [sic] all members of the University of Pittsburgh and characterized by R01 funding, excellent training records, productive collaborations and a dedication to understanding the pathophysiology of digestive diseases. Together they form a close and well-integrated entity dedicated to research training and investigations in gastroenterology, hepatology, pancreatic and nutritional disorders, with research foci ranging from small molecules to global human populations. Trainees will develop a research project under the close supervision of a faculty trainer and will be monitored by an advisory group or thesis committee as well as by a research training executive committee. Didactic lectures, research seminars, journal clubs, formal course work and attendance at scientific meetings will supplement this intensively structured research experience. Predoctoral graduates of this training program will be equipped to compete for individual training support. Postdoctoral graduates will be prepared to compete for independent funding and entry level faculty positions in academic medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK063922-10
Application #
8306333
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
2003-07-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$340,399
Indirect Cost
$21,123
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Rogal, Shari S; Bielefeldt, Klaus; Wasan, Ajay D et al. (2015) Fibromyalgia symptoms and cirrhosis. Dig Dis Sci 60:1482-9
Conti, Heather R; Peterson, Alanna C; Brane, Lucas et al. (2014) Oral-resident natural Th17 cells and ?? T cells control opportunistic Candida albicans infections. J Exp Med 211:2075-84
DeBerry, Jennifer J; Schwartz, Erica S; Davis, Brian M (2014) TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis. Pain 155:1280-7
LaRusch, Jessica; Jung, Jinsei; General, Ignacio J et al. (2014) Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis. PLoS Genet 10:e1004376
Bishu, Shrinivas; Su, Ee Wern; Wilkerson, Erich R et al. (2014) Rheumatoid arthritis patients exhibit impaired Candida albicans-specific Th17 responses. Arthritis Res Ther 16:R50
Stopczynski, Rachelle E; Normolle, Daniel P; Hartman, Douglas J et al. (2014) Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. Cancer Res 74:1718-27
Deberry, Jennifer J; Bielefeldt, Klaus; Davis, Brian M et al. (2014) Abdominal pain and the neurotrophic system in ulcerative colitis. Inflamm Bowel Dis 20:2330-9
Bishu, Shrinivas; Hernández-Santos, Nydiaris; Simpson-Abelson, Michelle R et al. (2014) The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. Infect Immun 82:1173-80
Rogal, Shari S; Winger, Daniel; Bielefeldt, Klaus et al. (2013) Healthcare utilization in chronic liver disease: the importance of pain and prescription opioid use. Liver Int 33:1497-503
Salerno, K M; Jing, X; Diges, C M et al. (2013) TRAF family member-associated NF-kappa B activator (TANK) expression increases in injured sensory neurons and is transcriptionally regulated by Sox11. Neuroscience 231:28-37

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