The goal of the program is to provide training to young researchers, at both the pre-doctoral and postdoctoral stages of their careers, in research that is relevant to diabetes, metabolism, and obesity. The Indiana University School of Medicine is an outstanding forum for such an initiative. Twenty two faculty from four Departments will participate as mentors in the program. This group of faculty has a strong training record and has over $7,500,000 of external funding. The program supports two pre-doctoral students and two post-doctoral fellows, and has successfully trained three students and two post-doctoral fellows over the four year period covered by this application. Pre-doctoral students will take a Minor in Diabetes and Obesity which includes a course in Diabetes and Obesity. Post-doctoral fellows will also take the course. Both students and post-doctoral fellows will attend Center for Diabetes Research seminars, will present their results in the same series, and will be encouraged to present their work at national meetings such as the American Diabetes Association scientific sessions. Additionally, they will take the Research Ethics course (G505). By training in an environment and culture that gives strong multi-disciplinary support for diabetes research, there is a significant probability that the trainees will sustain an interest in diabetes, even as their specific research interests evolve over their careers. Relevance. Diabetes mellitus is one of the predominant causes of premature loss of life in the United States and other developed countries. Furthermore, the incidence of type 2 diabetes is on the increase to the extent that it can be considered an epidemic in this country and one in three children born in 2003 is predicted to be afflicted with the disease in their lifetime. Therefore, it is important to provide training in the area of diabetes research with the goal of increasing the number of young researchers committed to careers confronting this common disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
Schools of Medicine
United States
Zip Code
Hiett, S Christopher; Owen, Meredith K; Li, Wennan et al. (2014) Mechanisms underlying capsaicin effects in canine coronary artery: implications for coronary spasm. Cardiovasc Res 103:607-18
Gallagher, Patricia J; Blue, Emily K (2014) Post-translational regulation of the cellular levels of DAPK. Apoptosis 19:306-15
Hoffman, Nolan J; Penque, Brent A; Habegger, Kirk M et al. (2014) Chromium enhances insulin responsiveness via AMPK. J Nutr Biochem 25:565-72
Baird, Thomas D; Palam, Lakshmi Reddy; Fusakio, Michael E et al. (2014) Selective mRNA translation during eIF2 phosphorylation induces expression of IBTK?. Mol Biol Cell 25:1686-97
Ruiz, Rafaela; Jideonwo, Victoria; Ahn, Miwon et al. (2014) Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. J Biol Chem 289:5510-7
He, Hongzhen; Singh, Isha; Wek, Sheree A et al. (2014) Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals. J Biol Chem 289:15023-34
Teske, Brian F; Fusakio, Michael E; Zhou, Donghui et al. (2013) CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Mol Biol Cell 24:2477-90
Nishiki, Yurika; Adewola, Adeola; Hatanaka, Masayuki et al. (2013) Translational control of inducible nitric oxide synthase by p38 MAPK in islet ?-cells. Mol Endocrinol 27:336-49
Gonzalez-Segura, Lilian; Ho, K-K; Perez-Miller, Samantha et al. (2013) Catalytic contribution of threonine 244 in human ALDH2. Chem Biol Interact 202:32-40
Owen, Meredith Kohr; Witzmann, Frank A; McKenney, Mikaela L et al. (2013) Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity. Circulation 128:9-18

Showing the most recent 10 out of 33 publications