The Indiana University Diabetes and Obesity Training Program began in 1999 and has been funded for ten years by NIDDK, currently at the level of two pre-doctoral and two post-doctoral trainees. The goal of the program is to provide training to young researchers at an early career stage of their careers, in research that is relevant to diabetes, metabolism, and obesity, an ever growing problem for the health of the nation. The Indiana University School of Medicine is an outstanding forum for such an initiative. Twenty four faculty from six departments will participate as mentors in the program. This group of faculty has a strong training record and has just short of $10M of external funding as PIs, with $3.7M from NIDDK and JDRF. For the upcoming cycle, support for three pre- and two post-doctoral trainees is requested. Pre-doctoral students will take a Minor in Diabetes and Obesity which includes a 3 credit Diabetes and Obesity course that has been recently developed. Post-doctoral fellows will also take the course. Both students and post-doctoral fellows will attend Center for Diabetes Research seminars, will present their results in the same series, and will be encouraged to present their work at national meetings such as the American Diabetes Association scientific sessions. Additionally, they will take a Research Ethics course and a Grant Writing Workshop. The program is sensitive to the issue of diversity and in the past funding cycle has recruited a hispanic and an African American trainee. By training in an environment and culture that gives strong multi-disciplinary support for diabetes research, there is a significant probability that th trainees will sustain an interest in diabetes, even as their specific research interests evolve ove their careers.

Public Health Relevance

Diabetes mellitus is one of the predominant causes of premature loss of life in the United States and other developed countries - the incidence of type 2, as well as type 1, diabetes is on the increase to the extent that diabetes has become one of the major health concerns in the United States. The problem of diabetes and obesity is widely reported by the popular press and other media outlets, and is reaching the consciousness of legislators in congress and the White House. It is important to provide training in the area of diabetes research with the objective of increasing the number of young researchers committed to careers confronting this common disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZDK1-GRB-R (J2))
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Castle, Arthur
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Indiana University-Purdue University at Indianapolis
Schools of Medicine
United States
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Hiett, S Christopher; Owen, Meredith K; Li, Wennan et al. (2014) Mechanisms underlying capsaicin effects in canine coronary artery: implications for coronary spasm. Cardiovasc Res 103:607-18
Gallagher, Patricia J; Blue, Emily K (2014) Post-translational regulation of the cellular levels of DAPK. Apoptosis 19:306-15
Hoffman, Nolan J; Penque, Brent A; Habegger, Kirk M et al. (2014) Chromium enhances insulin responsiveness via AMPK. J Nutr Biochem 25:565-72
Baird, Thomas D; Palam, Lakshmi Reddy; Fusakio, Michael E et al. (2014) Selective mRNA translation during eIF2 phosphorylation induces expression of IBTK?. Mol Biol Cell 25:1686-97
Ruiz, Rafaela; Jideonwo, Victoria; Ahn, Miwon et al. (2014) Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. J Biol Chem 289:5510-7
He, Hongzhen; Singh, Isha; Wek, Sheree A et al. (2014) Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals. J Biol Chem 289:15023-34
Teske, Brian F; Fusakio, Michael E; Zhou, Donghui et al. (2013) CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Mol Biol Cell 24:2477-90
Nishiki, Yurika; Adewola, Adeola; Hatanaka, Masayuki et al. (2013) Translational control of inducible nitric oxide synthase by p38 MAPK in islet ?-cells. Mol Endocrinol 27:336-49
Gonzalez-Segura, Lilian; Ho, K-K; Perez-Miller, Samantha et al. (2013) Catalytic contribution of threonine 244 in human ALDH2. Chem Biol Interact 202:32-40
Owen, Meredith Kohr; Witzmann, Frank A; McKenney, Mikaela L et al. (2013) Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity. Circulation 128:9-18

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