The Pediatric Endocrinology Research Training Program at the University of Chicago will train pediatric physician-scientist leaders in the investigation of endocrine diseases. This training program will help fill the national shortage of physician-scientists in the area of pediatric endocrinology. Two research training slots are requested in this competitive renewal application so that two trainees can be entered annually into a two-year research training program. Thus, this program is for trainees who have had introductory laboratory and course work in their initial year of pediatric endocrinology training and have developed a research project to which they are prepared to dedicate 80% effort for the two-year training period. The training is based in a combined Pediatric-Adult Endocrinology, Diabetes, and Metabolism unit, the Institute for Endocrine Discovery and Clinical Care which is now 6 years old. We are unique in the country with a fully integrated section that is a major training institution of dual boarded physician scientists in pediatric and adult endocrinology. The Senior Training Faculty numbers 15 investigators from four University departments (Medicine, Pediatrics, Human Genetics, Health Studies) who carry out a broad range of endocrine-related clinical and basic research supported by a substantial base of NIH and other peer-reviewed research grants including 27 R-awards, 2 K- awards, 5 P-awards and 6 U-awards. Each is an established investigator. In addition, the program is aided by the participation of 10 Associate Training Faculty and 5 additional resource training faculty from the Departments of Medicine, Pediatrics, Ob/Gyn and Health Studies. The University provides a rich environment of other faculty and physical resources. Trainees are selected on the basis of prior individual accomplishments including prior research training and experience as well as commitment to an academic research career. Trainees select a basic and clinical research mentor and an advisor, and the trainee and mentors jointly identify a primary and secondary research project. Trainees then undergo at least 3 years of training in the research laboratory of the preceptor(s), during which time they assume a progressively greater responsibility for developing research hypotheses, designing experiments, analyzing the data and preparing abstracts and scientific manuscripts. This research training occurs within the framework of a required core curriculum consisting of courses that describe and review current research methodology and research advances as well as statistical analysis of research data. The setting is one that emphasizes translational research and timely monitoring of trainee progress.

Public Health Relevance

The Pediatric Endocrinology Research Training Program at the University of Chicago has as its main objective to training of highly qualified physician-scientist leaders capable in the use of a variety of modern experimental techniques that will enable them to translate fundamental discoveries into improved medical care of diabetes and other endocrine disorders in the community. The University's strengths in community research, bioinformatics, molecular biology and clinical care posit the training program to train the very best students who will have an impact on the health and well-being of society.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK064582-12
Application #
8867222
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
2003-07-01
Project End
2019-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
12
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
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Greeley, Siri Atma W; Littlejohn, Elizabeth; Husain, Aliya N et al. (2017) The Effect of the Testis on the Ovary: Structure-Function Relationships in a Neonate with a Unilateral Ovotestis (Ovotesticular Disorder of Sex Development)?. Horm Res Paediatr 87:205-212
Koren, Dorit; O'Sullivan, Katie L; Mokhlesi, Babak (2015) Metabolic and glycemic sequelae of sleep disturbances in children and adults. Curr Diab Rep 15:562
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Rosenfield, Robert L; Bordini, Brian; Yu, Christine (2012) Comparison of detection of normal puberty in boys by a hormonal sleep test and a gonadotropin-releasing hormone agonist test. J Clin Endocrinol Metab 97:4596-604
Rosenfield, Robert L; Wroblewski, Kristen; Padmanabhan, Vasantha et al. (2012) Antimüllerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries. Fertil Steril 98:242-9
Rosenfield, Robert L; Bordini, Brian (2010) Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity. Brain Res 1364:186-97
Zimmer, Carrie A; Ehrmann, David A; Rosenfield, Robert L (2010) Potential diagnostic utility of intermittent administration of short-acting gonadotropin-releasing hormone agonist in gonadotropin deficiency. Fertil Steril 94:2697-702

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